Results 241 to 250 of about 211,042 (267)

Biased coin designs with a Bayesian bias

Journal of Statistical Planning and Inference, 1993
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
F. BALL, A. F. M. SMITH, VERDINELLI, Isabella   +2 more
openaire   +2 more sources

The 95% effective dose of intranasal dexmedetomidine sedation for pulmonary function testing in children aged 1-3 years: A biased coin design up-and-down sequential method.

Journal of clinical anesthesia, 2020
STUDY OBJECTIVE Intranasal dexmedetomidine (DEX) can provide adequate sedation during short examinations in children. However, we found no data regarding the 95% effective dose (ED95) of intranasal DEX for children's pulmonary function testing (PFT ...
Shangyingying Li, Hui Liu, Jing Zhang, Yang Liu, Qing Yu, Mang Sun, Qing Tian, Fei Yang, Y. Lei, Xiaoling Liu, Shengfen Tu   +10 more
semanticscholar   +1 more source

The 90% effective dose of intranasal dexmedetomidine for procedural sedation in children with congenital heart disease before and after surgery: A biased‐coin design up‐and‐down sequential allocation trial

Acta Anaesthesiologica Scandinavica, 2020
Intranasal dexmedetomidine can provide adequate sedation during short procedures. However, there are few reports investigating the effective dose of intranasal dexmedetomidine for sedation in children with congenital heart disease (CHD) before and after ...
Jing Zhang, Yu Cheng, Shangyingying Li, Hui Liu, Shengfen Tu   +4 more
semanticscholar   +1 more source

The power of Efron's biased coin design

Journal of Statistical Planning and Inference, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Tests Conditional on Imbalance with Biased Coin Designs.

1986
Abstract : Distributional properties of the treatment assignment variables T sub 1, ..., T sub n under Efron's (1971) biased coin design are derived. These properties are conditional on the terminal imbalance of the treatment allocation. Recursive procedures are presented for obtaining the conditional moments of T sub 1, ..., T sub n.
Edsel Pena, Myles Hollander
openaire   +1 more source

An optimal response adaptive biased coin design with k heteroscedastic treatments

Journal of Statistical Planning and Inference, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gwise, Thomas E., Zhou, Jianhui, Hu, Feifang   +2 more
openaire   +2 more sources

Dose Finding Using the Biased Coin Up‐and‐Down Design and Isotonic Regression

Biometrics, 2002
Summary.We are interested in finding a dose that has a prespecified toxicity rate in the target population. In this article, we investigate five estimators of the target dose to be used with the up‐and‐down biased coin design (BCD) Introduced By Durham and Flournoy (1994,Statistical Decision Theory and Related Topics).These estimators are derived using
Stylianou, Mario, Flournoy, Nancy
openaire   +3 more sources

On inferences from Wei's biased coin design for clinical trials

Biometrika, 1990
Wei (1988) analyzed data from a clinical trial in which an urn-sampling model was used to allocate patients to treatments. The trial resulted in 11 patients being allocated to the experimental treatment, all successes, and with one patient allocated to the control treatment, a failure.
openaire   +1 more source

An adaptive biased coin design for the behrens-fisher problem

Sequential Analysis, 1990
Wei(1978) introduced the adaptive biased coin design to reduce experimenter bias and offer a compromise between perfect balance and complete randomization. In situations such as the Behrens-Fisher problem, balance is not necessarily desired and the optimal ratio of sample sizes is unknown.
openaire   +1 more source

The adaptive accelerated biased coin design for phase I clinical trials

Journal of Applied Statistics, 2011
Phase I clinical trials are designed to study several doses of the same drug in a small group of patients to determine the maximum tolerated dose (MTD), which is defined as the dose that is associated with dose-limiting toxicity (DLT) in a desired fraction Γ of patients.
Nan Jia, Thomas M. Braun
openaire   +1 more source