Results 81 to 90 of about 185,950 (192)

Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice

Frontiers in Psychiatry, 2018
The transition from non-dependent alcohol use to alcohol dependence involves increased activity of the dorsal striatum. Interestingly, the dorsal striatum expresses a large number of inhibitory G-protein-coupled receptors (GPCRs), which when activated ...
Meridith T. Robins, Meridith T. Robins, Terrance Chiang, Terrance Chiang, Kendall L. Mores, Doungkamol Alongkronrusmee, Doungkamol Alongkronrusmee, Richard M. van Rijn, Richard M. van Rijn   +8 more
doaj   +1 more source

The signaling effect of tax policy. [PDF]

The paper focuses on the signaling value of a tax when agents are less informed than the government on the effect of their consumption. The policy making process is analyzed as a game in which the government wants to influence consumers' behaviors ...
Barigozzi, Francesca, Villeneuve, Bertrand   +1 more
core  

Kinetic multiplex assay to assess biased signaling of clinical GPCR agonists

Pharmacological Research
Studying biased signaling of G protein-coupled receptors (GPCRs) holds promise for the identification of ligands with a better therapeutic window. However, proper examination of biased signaling remains challenging by risking introduction of system or ...
Jara Bouma, Elisa J.M. de Koning, Cas van der Horst, Sanjay Sunil Kumar, Barry J.W. van den Berg, Samuel R.J. Hoare, Matthias B. Wittwer, Wolfgang Guba, Arne C. Rufer, Uwe Grether, Mario van der Stelt, Laura H. Heitman   +11 more
doaj   +1 more source

Labor Market Signaling and Self-Confidence: Wage Compression and the Gender Pay Gap [PDF]

I extend Spence's (1973) signaling model by assuming some workers are overconfident - they underestimate their marginal cost of acquiring education - and some are underconfident. Firms cannot observe workers' productive abilities and beliefs but know the
Luis Santos-Pinto
core  

The Signaling Role of Promotions: Further Theory and Empirical Evidence [PDF]

, 2006
[Excerpt] An extensive theoretical literature has developed that investigates the role of promotions as a signal of worker ability. There have been no tests, however, of the empirical validity of this idea. In this paper we develop the theory in a manner
Jed Devaro, Jed Devaro, Michael Waldman, Michael Waldman   +3 more
core   +4 more sources

RET is a sex-biased regulator of intestinal tumorigenesis

Frontiers in Gastroenterology
Ret is implicated in colorectal cancer (CRC) as both a proto-oncogene and a tumor suppressor. We asked whether RET signaling regulates tumorigenesis in an Apc-deficient preclinical model of CRC.
Sean T. Koester, Sean T. Koester, Naisi Li, Neelendu Dey, Neelendu Dey, Neelendu Dey   +5 more
doaj   +1 more source

To Be Biased or Not to Be: A Play for G-Protein Coupled Receptors

International Journal of Translational Medicine
G protein-coupled receptors (GPCRs) are the largest family of diverse receptors in eukaryotic organisms, playing a critical role in modulating human physiology. It therefore comes as no surprise that about 36% of all currently available drugs target this
Nikitas G. Liolitsas, Evangelia Pantazaka, Evangelia Papadimitriou   +2 more
doaj   +1 more source

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

eLife, 2018
Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink’ to facilitate evasion of host immune responses.
Timothy F Miles, Katja Spiess, Kevin M Jude, Naotaka Tsutsumi, John S Burg, Jessica R Ingram, Deepa Waghray, Gertrud M Hjorto, Olav Larsen, Hidde L Ploegh, Mette M Rosenkilde, K Christopher Garcia   +11 more
doaj   +1 more source

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]

, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, Traynor, John R   +4 more
core  

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source