Results 111 to 120 of about 14,906 (242)

Electron Microscopy and Multi‐Omics Reveal Mitochondrial Dysfunction and Structural Remodeling in the Hearts of Elderly Mice

Aging Cell, Volume 24, Issue 12, December 2025.
Integrated multi‐omics mapping of cardiac aging reveals mitochondrial dysfunction, profibrotic reprogramming, and lipotoxicity as key drivers of myocardial decline. A comprehensive spatial and molecular analysis of mouse hearts across aging (12, 24, and 30 months) uncovers coordinated disruptions in gene expression, protein homeostasis, and lipid ...
Manuela Giovanna Basilicata, Marco Malavolta, Serena Marcozzi, Eduardo Sommella, Lucia Scisciola, Fabrizio Merciai, Gianluca Fulgenzi, Valentina Golino, Giovanni Tortorella, Tatiana Spadoni, Laura Graciotti, Tania Ciaglia, Leonardo Schirone, Valentina Valenti, Sebastiano Sciarretta, Ceereena Ubaida‐Mohien, Carmine Pizzi, Rafael De Cabo, Pietro Campiglia, Lucia Altucci, Michelangela Barbieri, Fabiola Olivieri, Luigi Ferrucci, Giuseppe Paolisso   +23 more
wiley   +1 more source

The small leucine-rich proteoglycan, biglycan, is highly expressed in adipose tissue of Psammomys obesus and is associated with obesity and type 2 diabetes

Biologics: Targets & Therapy, 2012
Kristy Bolton1, David Segal1, Ken Walder1,21Metabolic Research Unit, School of Medicine, 2Institute for Technology, Research and Innovation, Deakin University, Waurn Ponds, Victoria, AustraliaAbstract: We have previously demonstrated that the small ...
Bolton K, Segal D, Walder K
doaj  

Glycosaminoglycans influence regional mechanics in young but not old Achilles tendons

The Journal of Physiology, Volume 603, Issue 23, Page 7589-7601, December 1, 2025.
Abstract figure legend Glycosaminoglycans (GAGs) are long, polysaccharide chains that are located between collagen fibrils in tendon and decrease with age in many musculoskeletal tissues. Yet, it is unknown whether declines in GAGs with age are responsible for age‐related changes to Achilles tendon mechanics.
Jonathon L. Blank, Jeremy D. Eekhoff, Louis J. Soslowsky   +2 more
wiley   +1 more source

Transforming growth factor-b regulation of proteoglycan synthesis in vascular smooth muscle: Contribution to lipid binding and accelerated atherosclerosis in diabetes [PDF]

, 2010
Atherosclerosis is accelerated in the setting of diabetes, but the factors driving this phenomenon remain elusive. Hyperglycemia leads to elevated levels of transforming growth factor (TGF)-b and TGF-b has been implicated as a factor in atherosclerosis ...
Burch, M, Evanko, S, Little, P, Osman, N, Tannock, L, Yang, S   +5 more
core  

Extracellular Vesicles From a Model of Melanoma Cancer‐Associated Fibroblasts Induce Changes in Brain Microvascular Cells Consistent With Pre‐Metastatic Niche Priming

Journal of Extracellular Biology, Volume 4, Issue 11, November 2025.
ABSTRACT Malignant melanoma has one of the lowest 5‐year survival rates of any cancer and is characterised by its high invasiveness and metastatic potential, with especially poor outcomes in patients who develop brain metastases. Crosstalk between melanoma cells and cells of the tumour microenvironment (TME), including cancer‐associated fibroblasts ...
Mikayla Shelton, Chinedu A. Anene, Jeremie Nsengimana, Mahmoud K. Eldahshoury, Jacob G. Gillet‐Woodley, Ben Keane, Wayne Roberts, Julia Newton‐Bishop, James R. Boyne   +8 more
wiley   +1 more source

Differential roles for small leucine-rich proteoglycans in bone formation

European Cells & Materials, 2003
This paper reviews our current state of knowledge of the roles the small leucine-rich proteoglycans (SLRPs) play in the formation of connective tissue and mineralised tissue matrices.
Waddington R. J., Roberts H. C., Sugars R. V., Schonherr E.   +3 more
doaj  

Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development1

Journal of Lipid Research, 2008
Angiotensin II (angII) is known to promote atherosclerosis; however, the mechanisms involved are not fully understood. To determine whether angII stimulates proteoglycan production and LDL retention, LDL receptor-deficient mice were infused with angII (1,
Fei Huang, Joel C. Thompson, Patricia G. Wilson, Hnin H. Aung, John C. Rutledge, Lisa R. Tannock   +5 more
doaj   +1 more source

Az érfal trombogenitása és annak szabályozása = Vessel wall thrombogenicity and its regulation [PDF]

, 2008
Fiziológiás hemosztázis ill. artériás trombózis keletkezésekor a trombociták a gyorsan áramló vérből von Willebrand faktoron keresztül tapadnak ki az érfalban lévő kollagénhez. Az érfal mátrix komponenseit vizsgálva megállapítottuk, hogy a media rétegből
Gombás, Judit, Komorowicz, Erzsébet, Váradi, Balázs   +2 more
core  

Effects of initial boost with TGF-beta 1 and grade of intervertebral disc degeneration on 3D culture of human annulus fibrosus cells [PDF]

, 2014
Background: Three-dimensional (3D) culture in porous biomaterials as well as stimulation with growth factors are known to be supportive for intervertebral disc cell differentiation and tissue formation.
Cluzel, Jessie, Endres, Michaela, Hegewald, Aldemar Andres, Kaps, Christian, Krüger, Jan Philipp, Thomé, Claudius   +5 more
core   +2 more sources

Investigation of Inflammation and Autophagy due to Biglycan-mediated TLR2/4 Signaling in Oral Lichen Planus Tissues [PDF]

Forbes Tıp Dergisi
Objective: Oral lichen planus (OLP) is a chronic oral mucosal disease of unknown etiology. Cellular immune response, basement membrane, and extracellular matrix (ECM) molecules are also noteworthy in the pathogenesis.
Özlem Ceren GÜNİZİ, Hüseyin GÜNİZİ, Hamiyet ECİROĞLU, Fatma YILDIZ   +3 more
doaj   +1 more source