BiomedicinesPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer type characterized by a marked desmoplastic tumor stroma that is formed under the influence of transforming growth factor (TGF)-β.
Hendrik Ungefroren +6 more
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Pharmaceuticals, 2017 The indispensable roles of dermatan sulfate-proteoglycans (DS-PGs) have been demonstrated in various biological events including construction of the extracellular matrix and cell signaling through interactions with collagen and transforming growth factor-
Shuji Mizumoto +3 more
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Versican splice variant messenger RNA expression in normal human Achilles tendon and tendinopathies [PDF]
, 2004 Versican is the principal large proteoglycan expressed in mid-tendon, but its role in tendon pathology is unknown. Our objective was to define the expression of versican isoform splice variant messenger ribonucleic acid (mRNA) in normal Achilles tendons,
Corps, AN +6 more
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Expression and the Prognostic Value of Biglycan in Gastric Cancer [PDF]
, 2022 Sizhe Hu +3 more
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Changes in macrophage phenotype and induction of epithelial‐to‐mesenchymal transition genes following acute Achilles tenotomy and repair [PDF]
, 2014 Tendon injuries occur frequently in physically active individuals, but the clinical outcomes for these injuries can be poor. In many injured tissues the repair process is orchestrated by two types of cells, macrophages and fibroblasts. Macrophages, which
Ansorge +44 more
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Noncrystalline uric acid inhibits proteoglycan and glycosaminoglycan synthesis in distal tubular epithelial cells (MDCK) [PDF]
, 2010 Hyperuricemia is associated with renal stones, not only consisting of uric acid (UrAc) but also of calcium oxalate (CaOx). Glycosaminoglycans (GAGs) are well-known inhibitors of growth and aggregation of CaOx crystals.
Borges, Fernanda Teixeira +3 more
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Prognostic value of biglycan in gastric cancer
, 2020 Abstract Background: BGN (biglycan) is a family member of small leucine-rich repeat proteoglycans. High expression of BGN might enhance the invasion and metastasis in some types of tumors. Here, the prognostic significance of BGN was evaluated in gastric cancer.Material and Methods: Two independent Gene Expression Omnibus (GEO) gastric cancer ...
Sizhe Hu +3 more
openaire +1 more source
High expression of biglycan is associated with poor prognosis in patients with esophageal squamous cell carcinoma [PDF]
, 2013 published_or_final_versio
Guan, X +5 more
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Achilles tendons from decorin- and biglycan-null mouse models have inferior mechanical and structural properties predicted by an image-based empirical damage model. [PDF]
, 2015 Achilles tendons are a common source of pain and injury, and their pathology may originate from aberrant structure function relationships. Small leucine rich proteoglycans (SLRPs) influence mechanical and structural properties in a tendon-specific manner.
Birk, David E. +5 more
core +2 more sources
The structure and function of cartilage proteoglycans [PDF]
European Cells & Materials, 2006 Cartilage contains a variety of proteoglycans that are essential for its normal function. These include aggrecan, decorin, biglycan, fibromodulin and lumican. Each proteoglycan serves several functions that are determined by both its core protein and its
P J Roughley
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