Results 51 to 60 of about 14,906 (242)

Biglycan regulated colorectal cancer progress by modulating enteric neuron-derived IL-10 and abundance of Bacteroides thetaiotaomicron

iScience, 2023
Summary: Biglycan (BGN) is a proteoglycan with branch chains and highly expressed in enteric neurons in the tumor tissue of colorectal cancer (CRC), which is negatively associated with survival rates in patients with CRC.
Yuyu Xu, Fei Wang, Kai Mi, Xinyuan Wang, Danlei Wang, Qing Zhao, Jingjing Wang, Zhi Liu, Qingqing Zhang, Yang Liu, Xuemei Zhang, Xingyin Liu   +11 more
doaj   +1 more source

Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy

Molecules, 2022
We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Eef Allegaert, Mohammad Mairaj Siddiquei, Ajmal Ahmad, Priscilla Gikandi, Gert De Hertogh, Ghislain Opdenakker   +7 more
doaj   +1 more source

Decorin as a multivalent therapeutic agent against cancer. [PDF]

, 2016
Decorin is a prototypical small leucine-rich proteoglycan that epitomizes the multifunctional nature of this critical gene family. Soluble decorin engages multiple receptor tyrosine kinases within the target-rich environment of the tumor stroma and tumor
Iozzo, Renato V., Neill, Thomas, Schaefer, Liliana   +2 more
core   +2 more sources

Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer

OncoImmunology, 2022
Cancer-associated fibroblasts (CAFs) are essential for tumor microenvironment remodeling and correlate with tumor progression. However, interactions between CAFs and tumor cells and immune cells in triple-negative breast cancer (TNBC) are still poorly ...
Shaoquan Zheng, Yutian Zou, Yuhui Tang, Anli Yang, Jie-Ying Liang, Linyu Wu, Wenwen Tian, Weikai Xiao, Xinhua Xie, Lu Yang, Jindong Xie, Weidong Wei, Xiaoming Xie   +12 more
doaj   +1 more source

Extracellular Matrix Proteomics: The mdx-4cv Mouse Diaphragm as a Surrogate for Studying Myofibrosis in Dystrophinopathy

Biomolecules, 2023
The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation.
Paul Dowling, Stephen Gargan, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +4 more
doaj   +1 more source

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis. [PDF]

JOR Spine
Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
Melrose J.
europepmc   +2 more sources

The Regulation of Aggrecanase ADAMTS-4 Expression in Human Achilles Tendon and tendon-Derived Cells [PDF]

, 2008
Several members of the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family have been identified as aggrecanases, whose substrates include versican, the principal large proteoglycan in the tendon extracellular matrix.
Corps, Anthony N., Curry, Valerie A., Harrall, Rebecca L., Hazleman, Brian L., Jones, Gavin C., Riley, Graham P.   +5 more
core   +2 more sources

Biglycan gene expression in UVR‐exposed rabbit corneas [PDF]

Acta Ophthalmologica Scandinavica, 2004
Abstract.Purpose: It is known that stromal proteoglycans play an important role in the hydration and transparency of the mammalian cornea. Proteoglycans have been described as a pathological deposit in climatic proteoglycan stromal keratopathy, which is associated with chronic ultraviolet radiation (UVR) exposure.
Alexander, Podskochy, Marina, Koulikovska, Per, Fagerholm, Ingeborg, van der Ploeg   +3 more
openaire   +2 more sources

TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle [PDF]

, 2011
Transforming growth factor-b (TGF-b) can mediate proteoglycan synthesis via Smad and non-Smad signalling pathways in vascular smooth muscle (VSM). We investigated whether TGF-b-mediated proteoglycan synthesis is via PI3K/Akt.
Burch, M, Getachew, A, Lancaster, G, Little AM, P, Osman, N, Wang, H, Wang, R, Zheng, W   +7 more
core   +1 more source

Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction [PDF]

Circulation, 2008
Background— After myocardial infarction (MI), extensive remodeling of extracellular matrix contributes to scar formation and preservation of hemodynamic function. On the other hand, adverse and excessive extracellular matrix remodeling leads to fibrosis and impaired function.
Westermann, D., Mersmann, J., Melchior, A., Freudenberger, T., Petrik, C., Schaefer, L., Lüllmann-Rauch, R., Lettau, O., Jacoby, C., Schrader, J., Brand-Herrman, S.M., Young, M.F., Schultheiss, H.P., Levkau, Bodo, Baba, Hideo Andreas, Unger, T., Zacharowski, K., Tschöpe, C., Fischer, J.W., Brand-Herrmann, S.-M.   +19 more
openaire   +3 more sources