Synthetic accesses to biguanide compounds [PDF]
Beilstein Journal of Organic Chemistry, 2021 Biguanide is a unique chemical function, which has attracted much attention a century ago and is showing resurgent interest in recent years after a long period of dormancy.
Oleksandr Grytsai +2 more
doaj +6 more sources
Application of antiseptic composition based on polyaminopropyl biguanide in the chronic catarrhal gingivitis treatment [PDF]
Эндодонтия Today, 2022 Inflammatory gum disease occupies a large proportion of oral diseases. Among the most honest complaints are concerns about bleeding gums, pain when eating.
A. A. Kulikova +5 more
doaj +9 more sources
Zur Kenntnis der Biguanide [PDF]
Journal für Praktische Chemie, 1911 n ...
Georg Cohn
openalex +5 more sources
Effects of Biguanide-PROTACs in Pancreatic Cancer Cells [PDF]
MoleculesThis study focuses on the synthesis of Biguanide-PROTACs, formed by conjugating the biguanide motif with a spacer and a ligand for recognition subunits of two E3 ubiquitin ligases.
Julie Vatté +3 more
doaj +2 more sources
Bactericidal effects of polyhexamethylene biguanide against intracellular Staphylococcus aureus EMRSA-15 and USA 300. [PDF]
Journal of Antimicrobial Chemotherapy, 2016 OBJECTIVES The treatment of skin infections caused by Staphylococcus aureus is limited by acquired antibiotic resistance and poor drug delivery into pathogen and host cells.
N. Kamaruzzaman, R. Firdessa, L. Good
semanticscholar +3 more sources
Mechanisms of NMDA Receptor Inhibition by Biguanide Compounds [PDF]
PharmaceuticalsN-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in this
Arseniy S. Zhigulin +2 more
doaj +2 more sources
Gaining Insight into Mitochondrial Targeting: AUTAC-Biguanide as an Anticancer Agent [PDF]
MoleculesAUTAC-Biguanide is a hybrid compound designed to target mitochondria, inducing their degradation by mitophagy. This study unveils the potential of biguanides as cancer cell-targeting agents, emphasizing AUTAC-Biguanide’s superior antiproliferative ...
Julie Vatté +3 more
doaj +2 more sources
Frontiers in Pharmacology, 2018 The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to ...
Federica Barbieri +13 more
doaj +2 more sources
Comparing the effects of biguanides and dipeptidyl peptidase-4 inhibitors on cardio-cerebrovascular outcomes, nephropathy, retinopathy, neuropathy, and treatment costs in diabetic patients. [PDF]
PLoS ONEBackgroundWestern guidelines often recommend biguanides as the first-line treatment for diabetes. However, dipeptidyl peptidase-4 (DPP-4) inhibitors, alongside biguanides, are increasingly used as the first-line therapy for type 2 diabetes (T2DM) in ...
Eiji Nakatani +14 more
doaj +2 more sources
Chemical imaging unveils mitochondria as the major site of medicinal biguanide accumulation within cells [PDF]
HeliyonMetformin (MET), a commonly prescribed medication for managing type 2 diabetes, has demonstrated various beneficial effects beyond its primary anti-diabetic efficacy.
Lei Wang +8 more
doaj +2 more sources