Results 11 to 20 of about 28,403 (287)
Molecules, 2021 Among the known biguanide drugs, proguanil has the best antiproliferative activity. In contrast, newly synthesized biguanide derivatives containing fluorine atoms have excellent biological activity, among which trifluoromethoxy compounds show the ...
Simeng Xu +6 more
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Frontiers in Chemistry, 2022 The challenge of infectious diseases remains a critical concern to the global public health. Recently, it is common to encounter touch-screen electronic devices everywhere to access services.
Hailemichael Ayalew +6 more
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Mild Biamidine-Transfer Conditions for the Synthesis of Aliphatic Biguanides
SynOpen, 2021 This study focuses on the development of new synthetic pathways to monosubstituted biguanides from amines. An exhaustive comparison of the conditions and reagents used for biamidine transfer was performed.
Rostyslav Bardovskyi +3 more
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Frontiers in Cellular and Infection Microbiology, 2023 Antimicrobial resistance is a critical public health issue that requires a thorough understanding of the factors that influence the selection and spread of antibiotic-resistant bacteria.
Raphaël Charron +9 more
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Comparative effectiveness of dipeptidyl peptidase-4 (DPP-4) inhibitors and human glucagon-like peptide-1 (GLP-1) analogue as add-on therapies to sulphonylurea among diabetes patients in the Asia-Pacific region: a systematic review [PDF]
, 2014 The prevalence of diabetes mellitus is rising globally, and it induces a substantial public health burden to the healthcare systems. Its optimal control is one of the most significant challenges faced by physicians and policy-makers.
A Juutilainen +58 more
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Synthesis of antibacterial polyether biguanide curing agent and its cured antibacterial epoxy resin
Designed Monomers and Polymers, 2021 At present, bacteria continue to threaten human health, and the resistance of bacteria to antibiotics continues to increase, so the development of new antibacterial agents and antibacterial materials is increasingly important to ensure human health.
Rui Li +6 more
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Synthesis, Characterization and Structural Analysis of Two New Biguanide Complexes
Crystals, 2023 This study reports on the synthesis and characterization of two new coordination compounds of the active pharmaceutical ingredient metformin and transition metals.
Andrea Pastrana-Dávila +4 more
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Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment
Cell Reports Medicine, 2020 Summary: Cancer cells display metabolic plasticity to survive stresses in the tumor microenvironment. Cellular adaptation to energetic stress is coordinated in part by signaling through the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK ...
Said Izreig +18 more
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Synthetic accesses to biguanide compounds
Beilstein Journal of Organic Chemistry, 2021 Biguanide is a unique chemical function, which has attracted much attention a century ago and is showing resurgent interest in recent years after a long period of dormancy.
Oleksandr Grytsai +2 more
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Repurposing Metabolic Inhibitors in the Treatment of Colon Adenocarcinoma Patient-Derived Models
Cells, 2023 The effect of agonists on AMP-activated protein kinase (AMPK), mainly metformin and phenformin, has been appreciated in the treatment of multiple types of tumors.
Bora Lee +5 more
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