Results 41 to 50 of about 9,884 (217)

Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth

Scientific Reports, 2021
We present the design and synthesis of a small library of substituted biguanidium salts and their capacity to inhibit the growth of pancreatic cancer cells.
Audrey Hébert, Maxime Parisotto, Marie-Camille Rowell, Alexandra Doré, Ana Fernandez Ruiz, Guillaume Lefrançois, Paloma Kalegari, Gerardo Ferbeyre, Andreea R. Schmitzer   +8 more
doaj   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

Disorder of Glucose Metabolism and Therapy: Implications on the Natural History of Advanced Chronic Liver Disease

GE: Portuguese Journal of Gastroenterology
Introduction: Hepatogenous diabetes (HD) is a disorder of glucose metabolism (DGM) that develops as a complication of advanced chronic liver disease (ACLD) with an estimated prevalence of 20–70%.
Sofia Garcês Soares, Tereza Frazão, Célia Tuna, Margarida Montes, Ana Rocha, Lígia Rodrigues Santos, Paulo Carrola, Sónia Carvalho, Inês Pinho, Luís Nogueira, Manuel Marques-Cruz, José Presa   +11 more
doaj   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Mechanism of Hydrogen Sulfide Generation and Prevention Strategies in Oil and Gas Fields: A Case Study of the Sickle Bay Operation Area

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT To address the persistent exceedance of hydrogen sulfide (H2S) concentrations and the limited effectiveness of existing treatments in the Sickle Bay oil production area, this study deeply analyzes the mechanism of H2S generation in the Sickle Bay oil production area and proposes targeted prevention and control strategies. The results show that
Bo Lei, Yao‐long Li, Bao‐ping Bai, Xiang‐de Zhang, Guan‐tao Shi, Yong‐long Xie, Chen‐xiao Hou, Cong‐Yu Ke   +7 more
wiley   +1 more source

Biguanides [PDF]

Diabetologia, 1978
M, Nattrass, K G, Alberti
openaire   +4 more sources

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

Cell Reports, 2019
Summary: AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk ...
Diana Vara-Ciruelos, Madhumita Dandapani, Fiona M. Russell, Katarzyna M. Grzes, Abdelmadjid Atrih, Marc Foretz, Benoit Viollet, Douglas J. Lamont, Doreen A. Cantrell, D. Grahame Hardie   +9 more
doaj   +1 more source

Trends in the utilization, expenditure and costs of noninsulin glucose‐lowering drugs in the Medicaid population: Steady increases in glucagon‐like peptide‐1 receptor agonist and sodium–glucose transporter‐2 inhibitor use, prices and expenditure

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
wiley   +1 more source

Arterial stiffness, as monitored by cardio–ankle vascular index, is affected by obstructive sleep apnea, blood glucose control, and body weight – a case with 8 years follow up

International Medical Case Reports Journal, 2016
Kazuhiro Shimizu,1 Tomoyuki Yamamoto,2,3 Kohji Shirai2,4 1Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan; 2Department of Vascular Function, Toho University Sakura Medical Center, Chiba, Japan; 3Biological Information
Shimizu K, Yamamoto T, Shirai K
doaj