Results 61 to 70 of about 15,321 (234)

History of current non-insulin medications for diabetes mellitus [PDF]

Journal of Community Hospital Internal Medicine Perspectives, 2012
This article is a brief review of the current non-insulin agents for diabetes mellitus in the United States, namely, sulfonylureas, biguanides, thiazolidinediones, meglitinides, α-glucosidase inhibitors, glucacon-like peptide-1 receptor agonists ...
Celeste C. L. Quianzon, Issam E. Cheikh
doaj   +1 more source

Repurposing Metabolic Inhibitors in the Treatment of Colon Adenocarcinoma Patient-Derived Models

Cells, 2023
The effect of agonists on AMP-activated protein kinase (AMPK), mainly metformin and phenformin, has been appreciated in the treatment of multiple types of tumors.
Bora Lee, ChuHee Lee, Hae-Min Moon, Se-Young Jo, Se Jin Jang, Young-Ah Suh   +5 more
doaj   +1 more source

Medication utilization patterns among type 2 diabetes patients initiating Exenatide BID or insulin glargine: a retrospective database study [PDF]

, 2013
BACKGROUND: Type 2 diabetes is a common and costly illness, associated with significant morbidity and mortality. Despite this, there is relatively little information on the ‘real-world’ medication utilization patterns for patients with type 2 diabetes ...
Barbara Johnson, Byron Hoogwerf, Gregory Lenhart, Machaon Bonafede, Manjiri Pawaskar, Robert Fowler   +5 more
core   +1 more source

Arterial stiffness, as monitored by cardio–ankle vascular index, is affected by obstructive sleep apnea, blood glucose control, and body weight – a case with 8 years follow up

International Medical Case Reports Journal, 2016
Kazuhiro Shimizu,1 Tomoyuki Yamamoto,2,3 Kohji Shirai2,4 1Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan; 2Department of Vascular Function, Toho University Sakura Medical Center, Chiba, Japan; 3Biological Information
Shimizu K, Yamamoto T, Shirai K
doaj  

Antidiabetic Regimen and Factors Associated with Glycemic Control in Patients with Type 2 Diabetes mellitus in Public Health Centers in Jakarta: A Cross-Sectional Study

Jurnal Manajemen dan Pelayanan Farmasi, 2021
Background:The glycemic control of diabetes mellitus patients is affected by many factors, including its antidiabetic regimen. Objectives: This study aimed to describe the antidiabetic regimen used in patients with T2DM in the public health centres in ...
Nora Wulandari, Maifitrianti Maifitrianti, Fadilla Muthi’ah, Nava Nur Disya   +3 more
doaj   +1 more source

Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth

Scientific Reports, 2021
We present the design and synthesis of a small library of substituted biguanidium salts and their capacity to inhibit the growth of pancreatic cancer cells.
Audrey Hébert, Maxime Parisotto, Marie-Camille Rowell, Alexandra Doré, Ana Fernandez Ruiz, Guillaume Lefrançois, Paloma Kalegari, Gerardo Ferbeyre, Andreea R. Schmitzer   +8 more
doaj   +1 more source

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides [PDF]

, 2013
As the concentrations of highly consumed nutrients, particularly glucose, are generally lower in tumours than in normal tissues1,2, cancer cells must adapt their metabolism to the tumour microenvironment. A better understanding of these adaptations might
A DeCensi, A Hall, A Hirayama, AF Santidrian, B Luo, BB Seo, Burcu Yucel, Clary B. Clish, David M. Sabatini, DB Shackelford, Erol C. Bayraktar, Franziska K. Lorbeer, G Tasseva, HG Crabtree, I Ben Sahra, J Barretina, JB Jones, JM Evans, K Birsoy, K Birsoy, Kıvanç Birsoy, M Jain, M Pollak, MR Owen, MY El-Mir, P Clerc, PM Gullino, Prathapan Thiru, R Possemato, RA Cairns, Richard Possemato, S Javeshghani, TB Haack, TC Larman, Tim Wang, Walter W. Chen, Y Urasaki   +36 more
core   +3 more sources

An ontological clinical decision support system based on clinical guidelines for diabetes patients in Sri Lanka [PDF]

, 2020
Health professionals should follow the clinical guidelines to decrease healthcare costs to avoid unnecessary testing and to minimize the variations among healthcare providers.
Dantanarayana, Gilmini, Ginige, Athula (R7725), Goonetillake, Jeevani S., Madhusanka, Sajith, Walisadeera, Anusha I.   +4 more
core   +1 more source

Liver uptake of Biguanides in rats

Biomedicine & Pharmacotherapy, 2011
Metformin is an oral antihyperglycaemic agent widely used in the management of non-insulin-dependent diabetes mellitus. The liver is the primary target, metformin being taken up into human and rat hepatocytes via an active transport mechanism. The present study was designed to compare hepatic uptake of two biguanides, metformin and phenformin, in vitro
Setsuko Komuro, Masashi Yabuki, Yoshihisa Sogame, Atsushi Kitamura   +3 more
openaire   +3 more sources

Prescribing pattern and pharmacoeconomic analysis of antidiabetic drugs [PDF]

, 2019
Background: Diabetes Mellitus is a worldwide growing problem causing threat to patient's health because of its association with various complications and comorbidities.
Arora, Shalini, Goyal, Pardeep Kumar, Kaushal, Sandeep, Mahajan, Bharti, Mittal, Naveen   +4 more
core   +2 more sources