Results 61 to 70 of about 22,636 (317)

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

Biochemical Journal, 2014
The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of mitochondrial respiratory complex I by metformin is the primary cause of its cell-lineage ...
H. R. Bridges, Andrew J. Y. Jones, M. Pollak, J. Hirst   +3 more
semanticscholar   +1 more source

Metformin: a modulator of bevacizumab activity in cancer? A case report. [PDF]

, 2015
Recurrent type I endometrial cancer ((EC)) has poor prognosis and demands novel therapeutic approaches. Bevacizumab, a VEGF-A neutralizing monoclonal antibody, has shown clinical activity in this setting. To our knowledge, however, although some diabetic
Aliberti, C, Casarin, A, Indraccolo, Stefano, Nardin, M, Nicoletto, Mo, Pomerri, Fabio, Randon, G, Zulato, E   +7 more
core   +1 more source

�ber die Biguanide [PDF]

Monatshefte f�r Chemie, 1891
n ...
openaire   +3 more sources

A Comprehensive Review of Clinical Studies on Bacterial Cellulose: From the Earliest Uses to Contemporary Innovations

Advanced Healthcare Materials, EarlyView.
Bacterial cellulose has undergone a transformative journey from early applications to its role in advanced regenerative medicine. The review has a pedagogical ambition, offering clear pathways for future research and clinical adoption. Harmonizing regulatory standards and conducting larger, well‐designed clinical trials with standardized endpoints will
Thomas Meslier, Justin Christopher D'Antin, Gemma Julio, Anna Roig   +3 more
wiley   +1 more source

Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

Frontiers in Pharmacology, 2018
The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to ...
Federica Barbieri, Roberto Würth, Alessandra Pattarozzi, Ivan Verduci, Chiara Mazzola, Maria G. Cattaneo, Michele Tonelli, Agnese Solari, Adriana Bajetto, Antonio Daga, Lucia M. Vicentini, Michele Mazzanti, Tullio Florio, Tullio Florio   +13 more
doaj   +1 more source

Retrospective nationwide study on the trends in first‐line antidiabetic medication for patients with type 2 diabetes in Japan

Journal of Diabetes Investigation, 2022
Aims/Introduction To investigate the national trend in the prescription of first‐line non‐insulin antidiabetic agents and total medical costs (TMCs) after prescribing the drug in Japanese patients with type 2 diabetes.
Ryotaro Bouchi, Takehiro Sugiyama, Atsushi Goto, Kenjiro Imai, Noriko Ihana‐Sugiyama, Mitsuru Ohsugi, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki   +8 more
doaj   +1 more source

Effects of Biguanides on Growth and Glycolysis of Bladder and Colon Cancer Cells

Anticancer Research, 2018
Background/ Aim: There is evidence that inhibitory effects of biguanides on oxidative phosphorylation require uptake of biguanides into the mitochondria.
M. Lea, Haneulsol Kim, C. Desbordes
semanticscholar   +1 more source

The thermodynamics of metabolism, cardiovascular performance and exercise, in health and diabetes: The objective of clinical markers [PDF]

, 2013
Extensive experience in UK National Health Service metabolic syndrome/type 2 diabetes clinics highlights the need for convenient clinical marker(s) which can be readily used to indicate the success or otherwise of alternative therapies.
Atherton, MA, Collins, MW, González-Alonso, J, König, CS, Ramachandran, S   +4 more
core  

LKB1 and AMPK and the cancer-metabolism link - ten years after [PDF]

, 2013
The identification of a complex containing the tumor suppressor LKB1 as the critical upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by metabolic stress was reported in an article in Journal of Biology in 2003.
A Decensi, A Hemminki, A Mora, A Street, A Woods, A Woods, A Woods, AF Baas, AK Al-Hakim, AS Marsin, AS Marsin, B Faubert, B Xiao, B Xiao, B Zheng, C Algire, C Canto, CM Sutherland, CW Lee, CW Song, D Carling, D Grahame Hardie, Dario R Alessi, DB Shackelford, DB Shackelford, DE Jenne, DG Hardie, DG Hardie, DG Hardie, DM Gwinn, DR Alessi, G Manning, G Zhou, GM Merrill, GV Thomas, H Ji, HA Hirsch, HM O'Neill, J Boudeau, J Liang, J Mankouri, JM Evans, JM Kyriakis, JM Lizcano, JS Oakhill, K Barnes, K Imamura, K Inoki, K Kato, K Sakamoto, KI Mitchelhill, L Liu, LA Yeh, M Foretz, M Jaleel, M Pollak, M Sanchez-Cespedes, MG Vander Heiden, MR Owen, N Nath, N Stahmann, O Warburg, P Tamas, RG Jones, RJ Shaw, RL Hurley, RR Russell, S Fogarty, S Hadad, S Horman, S Niraula, S Suissa, SA Hawley, SA Hawley, SA Hawley, SA Hawley, SA Hawley, SH Koo, SM Jeon, SN Wingo, SP Davies, SP Hong, TL Yuan, TS Ingebritsen, U Andersson, W Liu, WW Winder, WW Winder, WW Winder, X Huang, Y Yang   +90 more
core   +3 more sources