Results 71 to 80 of about 22,636 (317)

Zur Kenntniss des Biguanids [PDF]

Berichte der deutschen chemischen Gesellschaft, 1892
n ...
Bamberger, E.-U.-G., Dieckmann, W.
openaire   +2 more sources

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Metformin: Focus on Melanoma

Frontiers in Endocrinology, 2018
Metformin is the most common biguanide used in the treatment of diabetes, with 120 million treated patients worldwide. Metformin decreases hyperglycemia without inducing hypoglycemia in diabetic patients and is very well tolerated.
Emilie Jaune, Emilie Jaune, Stéphane Rocchi, Stéphane Rocchi   +3 more
doaj   +1 more source

Determination of Biguanide Groups in Polyhexamethylene Biguanide Hydrochloride by Titrimetric Methods

Analytical Sciences, 2003
The biguanide concentration of polyhexamethylene biguanide hydrochloride (PHMB-HCl) was measured by non-aqueous titration with HClO4, argentometric titration, the Kjeldhal method, and colloidal titration. The summation value of non-aqueous titration and argentometric titration corresponded to two titrable nitrogens in five nitrogens per one unit of ...
Toshiaki Hattori, Yasuko Nakata, Ryo Kato   +2 more
openaire   +3 more sources

Lactate‐Activated GPR132‐Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes

Advanced Science, EarlyView.
Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge, Shuying Wang, Zhaokai Li, Jing Yu, Binbin Liu, Ruiying Wang, Shichen Bu, Nawsher wan, Yan Wang, Cuilian Dai, Yijun Lin   +10 more
wiley   +1 more source

Role of Mitochondria in the Mechanism(s) of Action of Metformin

Frontiers in Endocrinology, 2019
Metformin is a drug from the biguanide family that is used for decades as the first-line therapeutic choice for the treatment of type 2 diabetes. Despite its worldwide democratization, owing to its clinical efficacy, high safety profile and cheap cost ...
Guillaume Vial, Guillaume Vial, Dominique Detaille, Bruno Guigas   +3 more
doaj   +1 more source

Comparison of decision tree with common machine learning models for prediction of biguanide and sulfonylurea poisoning in the United States: an analysis of the National Poison Data System

BMC Medical Informatics and Decision Making, 2023
Background Biguanides and sulfonylurea are two classes of anti-diabetic medications that have commonly been prescribed all around the world. Diagnosis of biguanide and sulfonylurea exposures is based on history taking and physical examination; thus ...
Omid Mehrpour, Farhad Saeedi, Samaneh Nakhaee, Farbod Tavakkoli Khomeini, Ali Hadianfar, Alireza Amirabadizadeh, Christopher Hoyte   +6 more
doaj   +1 more source

AMPK:a target for drugs and natural products with effects on both diabetes and cancer [PDF]

, 2013
The AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy that appears to have arisen at an early stage during eukaryotic evolution.
Chen, Cool, Corton, D. G. Hardie, Davies, Davies, El-Mir, Foretz, Greer, Hardie, Hardie, Hawley, Hawley, Hawley, Hawley, Huang, Hwang, Imamura, Jaleel, Ji, Jones, Liang, Lin, Lochhead, Lowell, Miners, Mooney, Musi, Oakhill, Rothwell, Rothwell, Scott, Stahmann, Suissa, Thaler, Timmers, Vara, Vincent, Woods, Woods, Xiao, Xiao, Yang, Yin   +43 more
core   +3 more sources

Comparison between olanexidine gluconate and conventional antiseptics for surgical site infection in gastroenterological surgery: A meta‐analysis

Annals of Gastroenterological Surgery, EarlyView.
This meta‐analysis compared olanexidine gluconate (OLG) with conventional antiseptics on surgical site infections (SSIs) in gastroenterological surgery. OLG significantly reduced overall SSIs without statistical heterogeneity. Abstract Aim To compare the preventative effect of the new antiseptic olanexidine gluconate (OLG) with conventional antiseptics
Akihisa Matsuda, Takeshi Yamada, Kay Uehara, Aya Yamagishi, Hiroshi Yoshida   +4 more
wiley   +1 more source

Medication utilization patterns among type 2 diabetes patients initiating Exenatide BID or insulin glargine: a retrospective database study [PDF]

, 2013
BACKGROUND: Type 2 diabetes is a common and costly illness, associated with significant morbidity and mortality. Despite this, there is relatively little information on the ‘real-world’ medication utilization patterns for patients with type 2 diabetes ...
Barbara Johnson, Byron Hoogwerf, Gregory Lenhart, Machaon Bonafede, Manjiri Pawaskar, Robert Fowler   +5 more
core   +1 more source