Results 81 to 90 of about 15,321 (234)

Metformin selectively targets redox control of complex I energy transduction [PDF]

, 2017
Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that are
Bacon, Sandra, Cameron, Amy R., Coats, Josh T., Curry, Heather, Erhardt, Stefan, Forteath, Calum, Harthill, Jean, Hassinen, Ilmo, Kerr, Calum, Logie, Lisa, McDougall, Gordon, Middleton, Paul, Patel, Kashyap, Paterson, Martin J., Rena, Graham, Repiščák, Peter, Sakamoto, Kei, Stewart, Derek   +17 more
core   +1 more source

Current insights into the effects of cationic biocides exposure on Enterococcus spp.

Frontiers in Microbiology
Cationic biocides (CBs), such as quaternary ammonium compounds and biguanides, are critical for controlling the spread of bacterial pathogens like Enterococcus spp., a leading cause of multidrug-resistant healthcare-associated infections.
Ana P. Pereira, Ana P. Pereira, Patrícia Antunes, Patrícia Antunes, Patrícia Antunes, Luísa Peixe, Luísa Peixe, Ana R. Freitas, Ana R. Freitas, Ana R. Freitas, Carla Novais, Carla Novais   +11 more
doaj   +1 more source

Glucose Deprivation Enhances the Antiproliferative Effects of Oral Hypoglycemic Biguanides in Different Molecular Subtypes of Breast Cancer: an in Vitro Study

Acta Pharmaceutica, 2018
Extensive in vitro studies have been conducted to evaluate the anticancer activity of oral hypoglycemic agents. Many of these studies experienced detrimental limitations, since they were conducted on cancer cells commonly grown in culture media ...
Bardaweel Sanaa K., Alsalamat Husam A., Aleidi Shereen M., Bashatwah Rasha M.   +3 more
doaj   +1 more source

Metformin:historical overview [PDF]

, 2017
Metformin (dimethylbiguanide) has become the preferred first-line oral blood glucose-lowering agent to manage type 2 diabetes. Its history is linked to Galega officinalis (also known as goat's rue), a traditional herbal medicine in Europe, found to be ...
A Beringer, A Qaseem, AJ Garber, AJ Garber, AJ Scheen, AW Ferguson, B Clarke, B Rathke, C Hadigan, C Pasik, C Pasik, C Wilcock, CJ Bailey, CJ Bailey, CJ Bailey, CJ Bailey, CJ Bailey, CJ Bailey, CJ Bailey, CJ Bailey, CJ Bailey, CJ Currie, CK Watanabe, Clifford J. Bailey, D Eurich, D Luft, DR Hadden, E Azerad, E Bosisio, EA Werner, EY Garcia, F Bischoff, FHS Curd, G Schäfer, G Ungar, GM Reaven, H Muller, HCS Howlett, HCS Howlett, IM Rabinowiz, IW Campbell, J Davidson, J Sterne, J Sterne, J Sterne, J Sterne, J Sterne, J Sterne, JA Johnson, JA Rowan, JB McKendry, JD Lalau, JE Nestler, JM Evans, KH Slotta, KK Chen, L Blonde, LJ McCreight, LS Hermann, M Nattrass, N Barzilai, N Wollen, NF Wiernsperger, NF Wiernsperger, PI Moreira, R Beckmann, RA DeFronzo, RA DeFronzo, RR Holman, RR Shah, RS Walker, SE Inzucchi, SL Shapiro, T Tankova, U Hostalek, UK Prospective Diabetes Study (UKPDS) Group, University Group Diabetes Program, WC Knowler, WJ Butterfield   +78 more
core   +2 more sources

Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The aim of this study was to assess in vitro the effects of sulphenamide and sulphonamide derivatives of metformin on the activity of human acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), establish the type of inhibition, and assess the ...
Magdalena Markowicz-Piasecka, Kristiina M. Huttunen, Joanna Sikora   +2 more
doaj   +1 more source

Using data mining techniques to explore physicians' therapeutic decisions when clinical guidelines do not provide recommendations: methods and example for type 2 diabetes [PDF]

, 2009
Background Clinical guidelines carry medical evidence to the point of practice. As evidence is not always available, many guidelines do not provide recommendations for all clinical situations encountered in practice.
A Sboner, Alain Venot, B Charbonnel, CA Silagy, J Lamy, Jean-Baptiste Lamy, K Morik, KC Abston, M Toussi, Massoud Toussi, MM Richards, PA de Clercq, Philippe Le Toumelin, R Bellazzi, R Raine, RN Shiffman, RN Shiffman, RN Shiffman, S Harris, S Mani, S Mani, SE Straus, SH Woolf, TM Mitchell, Type 2 diabetes treatment   +24 more
core   +3 more sources

Complexes of Biguanide and Malonic-Diamidine

, 1977
Complexes of Biguanide and Malonic-Diamidine.
Schwarzenbach, G., Schwarzenbach, D.
openaire   +3 more sources

Biguanides Induce Acute de novo Lipogenesis in Human Primary Sebocytes

Clinical, Cosmetic and Investigational Dermatology, 2020
James Nicoll, Benjamin M Buehrer Zen-Bio, Inc., Research Triangle Park, NC, USACorrespondence: Benjamin M BuehrerZen-Bio, Inc., 3200 East Highway 54, Suite 100, PO Box 13888, Research Triangle Park, NC 27709, USATel +1 919 547 0692Fax +1 919 547 ...
Nicoll J, Buehrer BM
doaj  

COMPLEX COMPOUNDS OF BIGUANIDE WITH BIVALENT METALS. PART IV. PALLADIUM BIGUANIDINE AND ITS SALTS [PDF]

, 1943
PRIYADARANJAN RAY, SAILAJA PRASAD GHOSE
openalex   +1 more source

Buformin exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells [PDF]

, 2016
Objective: Biguanides are anti-diabetic drugs that are thought to have anti-tumorigenic effects. Most pre-clinical studies have focused on metformin for cancer treatment and prevention; however, buformin may be potentially more potent than metformin ...
Bae-Jump, Victoria, Clark, Leslie, Gehrig, Paola, Gilliam, Timothy, Guo, Hui, Jackson, Amanda, Jones, Hannah, Kilgore, Joshua, Zhang, Lu, Zhou, Chunxiao   +9 more
core   +2 more sources