Results 111 to 120 of about 3,456,901 (302)

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling

, 2020
Theabrownin is one of the most bioactive compounds in Pu-erh tea. Our previous study revealed that the hypocholesterolemic effect of theabrownin was mediated by the modulation of bile salt hydrolase (BSH)-enriched gut microbiota and bile acid metabolism.
Shouli Wang, Kun Ge, Mengci Li, Chao Sang, Jiufeng Li, Xiaojiao Zheng, Shuiping Zhou, Aihua Zhao, Fengjie Huang, Wei Jia, Xiaohui Ma, Yitao Li, Junliang Kuang, Cynthia Rajani, Mingliang Zhao   +14 more
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Bile acid metabolism.

, 2015
Flow diagram showing the metabolism and fate of bile acids. In the liver (orange arrows), cholesterol is enzymatically converted to primary bile acids such as cholic acid.
Benjamin Kostiuk (789584), Daniel Unterweger (109620), Verena Bachmann (154491), Laura Diaz-Satizabal (789585), Stephen Ogg (789586), Stefan Pukatzki (277002)   +5 more
core   +1 more source

Exploring the mechanism of Jianpi Guchang recipe and its compound: Inhibition liver metastasis in colorectal carcinoma through regulation of the bile acid-FXR-FGF19 axis

Advances in Cancer Biology - Metastasis
Objective: To explore the main mechanism by which Jianpi Guchang recipe (JPGC) prevents liver metastasis in patients with intestinal cancer and explain the related microbiological changes that regulate bile acid metabolism.
Cunya Li, Pantong Wu, Zhonghua Wu, Jian Chen, Zhiying Wang, Zhixian Zhong, Yi Zhong, Shujuan Fu   +7 more
doaj   +1 more source

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

Scientific Reports, 2017
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR).
Kelly A. Fader, Rance Nault, Chen Zhang, Kazuyoshi Kumagai, Jack R. Harkema, Timothy R. Zacharewski   +5 more
doaj   +1 more source

Bile Acids, Microbiota, and Metabolism [PDF]

Hepatology, 2018
Sarah A, Taylor, Richard M, Green
openaire   +2 more sources

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

How bad is bile acid diarrhoea : an online survey of patient-reported symptoms and outcomes

, 2017
Objectives Bile acid diarrhoea (BAD) is an underdiagnosed condition producing diarrhoea, urgency and fear of faecal incontinence. How patients experience these symptoms has not previously been studied.
O'Connor, Michelle, Kelman, Lawrence, Arasaradnam, Ramesh P., Pitchford, Claire, Bannaga, Ayman, Walters, Julian R F   +5 more
core   +1 more source

Lipid composition and cholesterol nucleation time in gallbladder bile of patients with cholesterol gallstones under choleretic treatment with febuprol [PDF]

, 1988
The effect of a new potent choleretic drug (Febuprol) on lipid composition and cholesterol nucleation time in gallbladder bile was studied in 8 patients with cholesterol gallstones.
Paumgartner, Gustav, Pratschke, Ekkehard, Jüngst, Dieter, Brenner, Gerhard   +3 more
core   +1 more source