Results 101 to 110 of about 3,456,901 (302)
Bile Acid Metabolism in Liver Pathobiology
, 2018 Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain bile acid homeostasis, which is essential for protecting liver and other tissues and cells from cholesterol and bile acid toxicity. Bile acid metabolism is
Jessica M. Ferrell, John Y. L. Chiang
core +1 more source
An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer
Advanced Science, EarlyView.Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li +11 more
wiley +1 more source
High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. [PDF]
, 2015 Increased consumption of folic acid is prevalent, leading to concerns about negative consequences. The effects of folic acid on the liver, the primary organ for folate metabolism, are largely unknown.
Deng, L +10 more
core
Dysregulated bile acid homeostasis: unveiling its role in metabolic diseases
Medical ReviewMaintaining bile acid homeostasis is essential for metabolic health. Bile acid homeostasis encompasses a complex interplay between biosynthesis, conjugation, secretion, and reabsorption.
Wang Yanyan +4 more
doaj +1 more source
Advanced Science, EarlyView.This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun +7 more
wiley +1 more source
Fibronectin in human gallbladder bile: cholesterol pronucleating and/or mucin "link" protein? [PDF]
, 1994 Some biliary proteins (pronucleators) seem to be essential factors for cholesterol crystal formation and crystal growth in bile. A recent study suggests that fibronectin is such a pronucleator in bile.
Ritter, Christoph von +11 more
core +1 more source
Intestinal absorption, excretion, and biotransformation of hyodeoxycholic acid in man.
Journal of Lipid Research, 1983 Five patients fitted with a biliary T-tube after cholecystectomy were given orally a tracer dose of [14C]hyodeoxycholic acid and 500 mg of the same unlabeled acid.
E Sacquet +6 more
doaj +1 more source
Lipid Metabolism in Bile Acid Malabsorption
Annals of Medicine, 1990 Malabsorption of bile acid increases cholesterol synthesis and activates hepatic LDL receptors which leads to enhanced elimination of cholesterol from the body. Interruption of enterohepatic circulation of bile acids may lead to a smaller bile acid pool, which, in turn, impairs cholesterol and fat absorption by reduced micellar solubilization. Together
M, Färkkilä, T A, Miettinen
openaire +2 more sources
Advanced Science, EarlyView.ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou +9 more
wiley +1 more source
Short-Term Circadian Disruption Impairs Bile Acid and Lipid Homeostasis in MiceSummary
Cellular and Molecular Gastroenterology and Hepatology, 2015 Background & Aims: Bile acids are physiologic detergents that also activate nuclear receptors to regulate glucose and lipid homeostasis. Cholesterol 7α-hydroxylase (Cyp7a1), the rate-limiting enzyme that converts cholesterol to bile acids, is ...
Jessica M. Ferrell, John Y.L. Chiang
doaj +1 more source