Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]
, 2017 Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef +7 more
core +3 more sources
Review: microbial transformations of human bile acids
Microbiome, 2021 Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition. While the liver is responsible for the production of primary bile acids, microbes in the gut modify these compounds into myriad forms that greatly increase their ...
Douglas V. Guzior, Robert A. Quinn
doaj +1 more source
Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry [PDF]
, 2010 Bile acids are increasingly gaining attention since they were discovered to be activators of the transcription factor farnesoid X receptor (FXR) in addition to their well-established role in dietary lipid emulsification.
Alnouti +29 more
core +1 more source
Metabolites, 2020 Bile acids control lipid homeostasis by regulating uptake from food and excretion. Additionally, bile acids are bioactive molecules acting through receptors and modulating various physiological processes. Impaired bile acid homeostasis is associated with
Cristina Gómez +4 more
doaj +1 more source
Bile Acids: Major Regulator of the Gut Microbiome
Microorganisms, 2022 Bile acids are synthesized from cholesterol and play an important role in regulating intestinal microflora. The different degrees of hydrophobicity and acidity of individual bile acids may affect their antimicrobial properties.
Chihyeok An +14 more
doaj +1 more source
Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man [PDF]
, 2011 Background: Cholangiocytes expose a striking resistance against bile acids: while other cell types, such as hepatocytes, are susceptible to bile acid-induced toxicity and apoptosis already at micromolar concentrations, cholangiocytes are continuously ...
Amelsberg A +21 more
core +1 more source
Bile acids and bile alcohols of bullfrog.
Journal of Lipid Research, 1980 Gallbladder bile of the bullfrog, Rana cetesbeiana was found to contain a number of minor bile acids and bile alcohols in unconjugated forms. The following bile acids and bile alcohols were identified by combined gas-liquid chromatography-mass spectrometry: cholic acid, allocholic acid, 3 alpha,7 alpha,12 alpha-trihydroxy-5 alpha-cholestan-26-oic acid,
Minori Yasuda +5 more
openaire +4 more sources
Bile acids during pregnancy: Trimester variations and associations with glucose homeostasis
Health Science Reports, 2021 Background and aims Bile acids are known to contribute to hepatic glucose and lipid metabolism regulation. Although glucose homeostasis sustains well‐characterized modifications during uncomplicated pregnancies, changes in bile acids concentrations and ...
Marianne Gagnon +6 more
doaj +1 more source
Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]
, 2004 Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Fischer, S. +5 more
core +1 more source
Bile resistance and bile salt deconjugation activity of Bifidobacterium pseudocatenulatum G4 in a simulated colonic pH. [PDF]
, 2011 The ability of Bifidobacterium pseudocatenulatum G4 to survive and tolerate bile acids exposure and its bile salt hydrolase activity was investigated. The growth rate of B.
Abd. Manap, Mohd. Yazid +5 more
core +2 more sources