Results 31 to 40 of about 234,802 (359)

REMEDI: REinforcement learning-driven adaptive MEtabolism modeling of primary sclerosing cholangitis DIsease progression [PDF]

arXiv, 2023
Primary sclerosing cholangitis (PSC) is a rare disease wherein altered bile acid metabolism contributes to sustained liver injury. This paper introduces REMEDI, a framework that captures bile acid dynamics and the body's adaptive response during PSC progression that can assist in exploring treatments.
arxiv  

Development and Validation of a Highly Sensitive LC-MS/MS Method for the Analysis of Bile Acids in Serum, Plasma, and Liver Tissue Samples

Metabolites, 2020
Bile acids control lipid homeostasis by regulating uptake from food and excretion. Additionally, bile acids are bioactive molecules acting through receptors and modulating various physiological processes. Impaired bile acid homeostasis is associated with
Cristina Gómez, Simon Stücheli, Denise V. Kratschmar, Jamal Bouitbir, Alex Odermatt   +4 more
doaj   +1 more source

Microbiome-derived bile acids contribute to elevated antigenic response and bone erosion in rheumatoid arthritis [PDF]

arXiv, 2023
Rheumatoid arthritis (RA) is a chronic, disabling and incurable autoimmune disease. It has been widely recognized that gut microbial dysbiosis is an important contributor to the pathogenesis of RA, although distinct alterations in microbiota have been associated with this disease.
arxiv  

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man [PDF]

, 2011
Background: Cholangiocytes expose a striking resistance against bile acids: while other cell types, such as hepatocytes, are susceptible to bile acid-induced toxicity and apoptosis already at micromolar concentrations, cholangiocytes are continuously ...
Amelsberg A, Batzri S, Beuers U, Beuers U, Douglas M. Jefferson, Duane WC, Eastwood GL, Hofmann AF, Hohenester S, Hov JR, Lucas Maillette de Buy Wenniger, Medina JF, Melero S, Minagawa N, Poupon R, Prieto J, Prieto J, Ronald P. Oude Elferink, Rust C, Simon Hohenester, Spivey JR, Ulrich Beuers   +21 more
core   +1 more source

Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry [PDF]

, 2010
Bile acids are increasingly gaining attention since they were discovered to be activators of the transcription factor farnesoid X receptor (FXR) in addition to their well-established role in dietary lipid emulsification.
Alnouti, Ando, Arnold von Eckardstein, Bentayeb, Bjorkhem, Burkard, Camilleri, Carine Steiner, Cariou, Caron, Claudel, DeBarber, Duran-Sandoval, Honda, Karuna, Katharina M. Rentsch, Kuipers, Lefebvre, Lovgren-Sandblom, Makishima, Parks, Sauter, Scherer, Staels, Tagliacozzi, Tessier, Wang, Xiang, Ye, Zhang   +29 more
core   +1 more source

Bile dynamics within the biliary tract and microfluidic-based bile component detection: A review [PDF]

arXiv, 2023
Bilestones are solid masses found in the gallbladder or biliary tract, which block the normal bile flow and eventually result in severe life-threatening complications. Studies have shown that bilestone formation may be related to bile flow dynamics and the concentration level of bile components.
arxiv  

Differential modulation of cellular death and survival pathways by conjugated bile acids [PDF]

, 2001
BACKGROUND: The liver-derived McNtcp.24 cells transport bile acids and show distinctive responses to the two classes of conjugated bile acids. Whereas taurine-conjugated bile acids are non-toxic, glycine-conjugated bile acids efficiently induce apoptosis.
Agellon, Luis B, Stolz, Andrew, Torchia, Enrique C   +2 more
core   +3 more sources

Bile acids and bile alcohols of bullfrog.

Journal of Lipid Research, 1980
Gallbladder bile of the bullfrog, Rana cetesbeiana was found to contain a number of minor bile acids and bile alcohols in unconjugated forms. The following bile acids and bile alcohols were identified by combined gas-liquid chromatography-mass spectrometry: cholic acid, allocholic acid, 3 alpha,7 alpha,12 alpha-trihydroxy-5 alpha-cholestan-26-oic acid,
Minori Yasuda, Takahiko Hoshita, Kenji Kihira, Yukio Noma, Mizuho Une, Taiju Kuramoto   +5 more
openaire   +4 more sources

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Adachi Y, Brendel C, Christian Zimmermann, Christoph Beglinger, Denk GU, Denson LA, Dietrich CG, Dietrich CG, Ee PL, Frank Lehmann, Freeman LA, Geier A, Gutmann H, Heike Gutmann, Hruz P, Imai Y, Janvilisri T, Jonker JW, Juergen Drewe, Jung D, Jung D, Kamisako T, Klucken J, Li N, Lown KS, Lu TT, Luigi Terracciano, Maliepaard M, Miyake K, Petr Hruz, Plebani M, Popowski K, Schellens JH, Smith M, Stedman CA, Stellaard F, Suzuki M, Taipalensuu J, Tanaka Y, Tanaka Y, Trauner M, Ulrich Beuers, van Herwaarden AE, Volk EL, Wagner M, Xie W, Yu L, Zimmermann C, Zollner G   +48 more
core   +1 more source

Fecal bile acids and neutral sterols are associated with latent microbial subgroups in the human gut [PDF]

, 2022
Bile acids, neutral sterols, and the gut microbiome are intricately intertwined and each affects human health and metabolism. However, much is still unknown about this relationship. This analysis included 1280 participants of the KORA FF4 study.
Adamski, Jerzy, Artati, Anna, Breuninger, Taylor A., Freuer, Dennis, Grallert, Harald, Haller, Dirk, Linseisen, Jakob, Meisinger, Christa, Peters, Annette, Reitmeier, Sandra, Wawro, Nina   +10 more
core   +2 more sources