Results 31 to 40 of about 139,449 (267)

Effect of bile acid deconjugation on the fecal excretion of steroids

Journal of Lipid Research, 1970
The effect of microbiological deconjugation of bile acids on total bile acid and neutral sterol fecal excretion by adult male rats has been studied. A screening method utilizing mice allowed selection of a Clostridium perfringens type A strain, which ...
Thomas F. Kellogg, P. Leonard Knight, Bernard S. Wostmann   +2 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Similarity of unusual bile acids in human umbilical cord blood and amniotic fluid from newborns and in sera and urine from adult patients with cholestatic liver diseases

Journal of Lipid Research, 1988
Unusual bile acids in umbilical cord blood and amniotic fluid of term newborns and in sera and urine from adult patients with cholestatic liver diseases were analyzed by use of gas-liquid chromatography-mass spectrometry.
J Shoda, R Mahara, T Osuga, M Tohma, S Ohnishi, H Miyazaki, N Tanaka, Y Matsuzaki   +7 more
doaj   +1 more source

Lower bile acids as an independent risk factor for renal outcomes in patients with type 2 diabetes mellitus and biopsy-proven diabetic kidney disease

Frontiers in Endocrinology, 2022
AimsAbnormalities of glucolipid metabolism are critical mechanisms involved in the progression of diabetic kidney disease (DKD). Bile acids have an essential role in regulating glucolipid metabolism.
Xiang Xiao, Xiang Xiao, Xiang Xiao, Junlin Zhang, Shuming Ji, Chunmei Qin, Chunmei Qin, Yucheng Wu, Yucheng Wu, Yutong Zou, Yutong Zou, Jia Yang, Jia Yang, Yuancheng Zhao, Yuancheng Zhao, Qin Yang, Qin Yang, Fang Liu, Fang Liu   +18 more
doaj   +1 more source

Printed Integrated Logic Circuits Based on Chitosan‐Gated Organic Transistors for Future Edible Systems

Advanced Functional Materials, EarlyView.
Edible electronics needs integrated logic circuits for computation and control. This work presents a potentially edible printed chitosan‐gated transistor with a design optimized for integration in circuits. Its implementation in integrated logic gates and circuits operating at low voltage (0.7 V) is demonstrated, as well as the compatibility with an ...
Giulia Coco, Valerio Francesco Annese, Valerio Galli, Ilaria Penna, Debora Russo, Marina Veronesi, Rita Scarpelli, Stefania Sabella, Mario Caironi   +8 more
wiley   +1 more source

Preference of Conjugated Bile Acids over Unconjugated Bile Acids as Substrates for OATP1B1 and OATP1B3. [PDF]

PLoS ONE, 2017
Bile acids, the metabolites of cholesterol, are signaling molecules that play critical role in many physiological functions. They undergo enterohepatic circulation through various transporters expressed in intestine and liver.
Takahiro Suga, Hiroaki Yamaguchi, Toshihiro Sato, Masamitsu Maekawa, Junichi Goto, Nariyasu Mano   +5 more
doaj   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Journal of Lipid Research, 2014
During the last 80 years there have been extraordinary advances in our knowledge of the chemistry and biology of bile acids. We present here a brief history of the major achievements as we perceive them.
Alan F. Hofmann, Lee R. Hagey
doaj   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Development of a Novel Synthetic Hydrogel Sealant for Effective Prevention of Liver Resection‐Associated Bile Leakage

Advanced Healthcare Materials, EarlyView.
A dual‐crosslinking poly(ethylene glycol) (PEG) hydrogel is presented that rapidly solidifies and progressively adheres to tissue, achieving durable sealing of bile leaks. In hepatectomy models, this system prevents postoperative complications more effectively than conventional sealants, highlighting its translational potential as a safe and efficient ...
Kazuyoshi Matsubara, Shohei Ishikawa, Hiroyuki Kamata, Almog Gur, Ayano Fujisawa, Shu Nishida, Katsuyuki Hoshina, Takamasa Sakai   +7 more
wiley   +1 more source