Results 11 to 20 of about 57,138 (354)

Role of Bile Acids and Bile Salts in Acute Pancreatitis

Pancreas, 2020
Abstract Acute pancreatitis (AP) is one of the most common gastroenterological disorders leading to hospitalization. It has long been debated whether biliary AP, about 30% to 50% of all cases, is induced by bile acids (BAs) when they reach the pancreas via reflux or via the systemic blood circulation.
Quang Trung Tran, Van Huy Tran, Matthias Sendler, Julia Doller, Mats L. Wiese, Robert Bolsmann, Anika Wilden, Juliane Glaubitz, Jana Marielle Modenbach, Franziska G. Thiel, Laura L. de Freitas Chama, Frank Ulrich Weiß, Markus M. Lerch, Ali A. Aghdassi   +13 more
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Bile Acids and Bile Salts: Ionization and Solubility Properties [PDF]

Hepatology, 1984
The number, position and orientation of nuclear OH substituents profoundly influence the equilibrium solubilities of undissociated bile acids in water. Estimates from several studies range from 5 × 10″8 for lithocholic acid to 1.6 × 10−3 Af for ursocholic acid at 37°C.
Martin C. Carey
openalex   +3 more sources

Bile Salt Composition and Distribution of the D-Cysteinolic Acid Conjugated Bile Salts in Fish

Fisheries science, 1996
Takanobu Goto, Takuji Ui, Mizuho Une, Taiju Kuramoto, Kenji Kihira, Takahiko Hoshita   +5 more
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Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling [PDF]

Nature Communications, 2016
AbstractAutotaxin (ATX) generates the lipid mediator lysophosphatidic acid (LPA). ATX-LPA signalling is involved in multiple biological and pathophysiological processes, including vasculogenesis, fibrosis, cholestatic pruritus and tumour progression. ATX has a tripartite active site, combining a hydrophilic groove, a hydrophobic lipid-binding pocket ...
Willem‐Jan Keune, Jens Hausmann, Ruth Bolier, Dagmar Tolenaars, Andreas E. Kremer, Tatjana Heidebrecht, Robbie P. Joosten, Manjula Sunkara, Andrew J. Morris, Elisa Matas-Rico, Wouter H. Moolenaar, Ronald P.J. Oude Elferink, Anastassis Perrakis   +12 more
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Zebrafish olfactory receptors ORAs differentially detect bile acids and bile salts [PDF]

Journal of Biological Chemistry, 2019
The fish olfactory receptor ORA family is orthologous to the mammalian vomeronasal receptors type 1. It consists of six highly conserved chemosensory receptors expected to be essential for survival and communication. We deorphanized the zebrafish ORA family in a heterologous cell system. The six receptors responded specifically to lithocholic acid (LCA)
Xiaojing Cong, Qian Zheng, Wenwen Ren, Jean-Baptiste Chéron, Sébastien Fiorucci, Tieqiao Wen, Chunbo Zhang, Hongmeng Yu, Jérôme Golebiowski, Yiqun Yu   +9 more
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Expression, purification, crystallization and preliminary X-ray diffraction analysis of conjugated bile salt hydrolase from Bifidobacterium longum [PDF]

, 2004
Conjugated bile salt hydrolase (BSH) catalyses the hydrolysis of the amide bond that conjugates bile acids to glycine and to taurine. The BSH enzyme from Bifidobacterium longum was overexpressed in Escherichia coli BL21(DE3), purified and crystallized ...
Brannigan, J A, Dodson, G G, Kumar, R S, Prabhune, A, Pundle, A, Suresh, C G   +5 more
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Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents

Journal of Lipid Research, 2017
In addition to functioning as detergents that aid digestion of dietary lipids in the intestine, some bile acids have been shown to exhibit antimicrobial activity.
Masamichi Watanabe, Satoru Fukiya, Atsushi Yokota   +2 more
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Bile salts of vertebrates: structural variation and possible evolutionary significance[S]

Journal of Lipid Research, 2010
Biliary bile salt composition of 677 vertebrate species (103 fish, 130 reptiles, 271 birds, 173 mammals) was determined. Bile salts were of three types: C27 bile alcohols, C27 bile acids, or C24 bile acids, with default hydroxylation at C-3 and C-7.
Alan F. Hofmann, Lee R. Hagey, Matthew D. Krasowski   +2 more
doaj   +1 more source

Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]

, 2018
The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan, Dunn, Kenneth W., Dunn, Robert T., Morgan, Ryan E., Ryan, Jennifer, Volak, Laurie P.   +5 more
core   +1 more source

The Role of Bile in the Regulation of Exocrine Pancreatic Secretion [PDF]

, 1992
As early as 1926 Mellanby (1) was able to show that introduction of bile into the duodenum of anesthetized cats produces a copious flow of pancreatic juice.
Adamczyk W, Andrén-Sandberg A, Aronchick CA, Björnsson OG, Björnsson OG, Brand SJ, Burhol PG, Davies HA, Dragstedt LR, Erlinger S, Eyre-Brook IA, Fausa O, Fiedler F, Forell MM, Forell MM, Forell MM, Forell MM, Forell MM, Frühauf S, Fölsch UR, Geratz JD, Gomez G, Green GM, Gries E, Grundy SM, Hanssen LE, Hartmann W, Hellmann G, Holtermuller KH, Holtermuller KH, Hotz J, Ivy AC, Kataoka K, Konturek SJ, Koop I, Koop I, Koop I, Koop I, Koop I, Kurosawa H, Kuroyanagi Y, Lagerlöf HO, Lehnert P, Lueth HC, Malagelada J-R, Malagelada J-R, Malagelada J-R, Mellanby J, Meyer JH, Miyasaka K, Miyasaka K, Miyasaka K, Miyasaka K, Nakamura R, Nakamura R, Namba M, Nustede R, Ohta H, Osnes M, Osnes M, Osnes M, Osnes M, Otte M, Peter Lehnert, Riepl RL, Riepl RL, Riepl RL, Riepl RL, Rudolf L. Riepl, Schaffalitzky de Muckadell OB, Shiratori K, Smallwood RA, Staub VL, Thomas JE, van Levan H, Wormsley KG   +75 more
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