Results 101 to 110 of about 45,839 (288)

Solubilization of Vitamin K1 by Bile Salts and Phosphatidylcholine-Bile Salts Mixed Micelles

, 1988
The solubilization of vitamin K1 by bile salts (sodium deoxycholate, sodium cholate and their corresponding glycine conjugates) and phosphatidylcholine (egg)-bile salt mixed micelles has been investigated. The solubilization curves were not always linear
Toshihisa Yotsuyanagi, Ken Ikeda, Mariko Nagata   +2 more
core   +1 more source

Controllable engineered probiotic microspheres for treating ulcerative colitis: A cascade enzyme‐catalyzed strategy to restore intestinal redox homeostasis

BMEMat, EarlyView.
A dual strategy integrating genetic engineering and physical encapsulation was proposed to enhance the cell viability and antioxidant properties of probiotics. The cascade antioxidant enzymes released from probiotic microspheres restore intestinal redox homeostasis by eliminating intestinal reactive oxygen species for ulcerative colitis treatment ...
Xiaolong Mao, Xiangwei Lv, Miaomiao Zhang, Jiayi Liu, Yun Chen, Yunna Li, Gaoyuan Liu, Fuming Yang, Ziqiang Han, Yunyun Wei   +9 more
wiley   +1 more source

Auto-associação do colato de sódio (NaC) em misturas com o surfactante aniônico dodecil sulfato de sódio (SDS) e o polímero neutro hidrossolúvel poli(óxido de etileno) (PEO) [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em QuímicaAs propriedades de misturas de poli(óxido de etileno) (PEO) e colato de sódio (NaC) em solução tampão tris/HCl,
Felippe, Arlindo Cristiano
core  

Influence of bile salts on the gastrointestinal digestion of agar-casein hybrid systems and the nanoassembly of their digestion products [PDF]

[EN] This manuscript reports on the effect of different bile salts concentration on the gastrointestinal digestion of casein and casein-agar hybrid systems and evaluates the effect on the nanostructural assembly of the digestion products through the ...
Fontes-Candia, Cynthia, Recio, Isidra, Martínez Sanz, Marta, Díaz-Piñero, Laura, Rodríguez-Dobreva, Estefania, Fontes Candia, Cynthia, Martínez-Sanz, Marta   +6 more
core   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Protection against hydrophobic bile salt-induced cell membrane damage by liposomes and hydrophilic bile salts

, 1993
Under physiological circumstances, cell membrane damage is not evident in biliary systems, despite the fact that hydrophobic bile salts are known to induce such damage by their detergent effects. The aim of this study was to determine the cytoprotective
S. Tazuma, H. Sagawa, G. Kajiyama
core   +1 more source

Lipid components of bile increase the protective effect of conjugated bile salts against antifungal drugs [PDF]

, 2017
Fungi and bacteria can persist in the human gall bladder. Previous studies have shown that bile protects Candida albicans in this cryptic host niche from antifungals, providing a reservoir for intestinal re-colonization after discontinuation of ...
Shih-Hung Hsieh, Brock, Matthias, Matthias Brock, Hsieh, Shih-Hung   +3 more
core   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Bile salt signaling and bile salt-based therapies in cardiometabolic disease

Clinical Science
Abstract Bile salts have an established role in the emulsification and intestinal absorption of dietary lipids, and their homeostasis is tightly controlled by various transporters and regulators in the enterohepatic circulation. Notably, emerging evidence points toward bile salts as major modulators of cardiometabolic disease (CMD), an ...
Claire C.J. Groenen, Thuc-Anh Nguyen, Coen C. Paulusma, Stan F.J. van de Graaf   +3 more
openaire   +2 more sources

Resistance to antimicrobial agents in bifidobacteria

, 2005
Includes bibliographical references (leaves 95-106).For bifidobacteria to survive and achieve colonisation, they have to interact with inhibitory host-produced substances such as bile salts.
Price, Claire Emile
core