Results 91 to 100 of about 8,224,245 (384)

Effects of cytosine methylation on transcription factor binding sites

BMC Genomics, 2014
DNA methylation in promoters is closely linked to downstream gene repression. However, whether DNA methylation is a cause or a consequence of gene repression remains an open question.
Y. Medvedeva, Abdullah M. Khamis, I. Kulakovskiy, W. Ba-alawi, M. S. Bhuyan, H. Kawaji, T. Lassmann, M. Harbers, A. Forrest, V. Bajic   +9 more
semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Altered density of glomerular binding sites for atrial natriuretic factor in bile duct-ligated rats with ascites [PDF]

, 1991
The renal response to atrial natriuretic factor is blunted in cirrhosis with ascites. This might be due to alterations of renal receptors for atrial natriuretic factor.
Almeida, Arendt, Arendt, Ballermann, Cantin, Chinkers, De Léan, Epstein, Garcia, Gauquelin, Gauquelin, Gerbes, Gerbes, Gerbes, Gerbes, Gines, Kollenda, Kollenda, Kountouras, Laffi, Lang, Lowry, Maack, Misra, Morgan, Munson, Needleman, Olivera, Panos, Petrillo, Salerno, Thibault   +31 more
core   +1 more source

Circular RNAs are depleted of polymorphisms at microRNA binding sites

Bioinform., 2014
Motivation: Circular RNAs (circRNAs) are an abundant class of highly stable RNAs that can affect gene regulation by binding and preventing microRNAs (miRNAs) from regulating their messenger RNA (mRNA) targets.
Laurent F. Thomas, P. Sætrom
semanticscholar   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

c-Myb Binding Sites in Haematopoietic Chromatin Landscapes. [PDF]

PLoS ONE, 2015
Strict control of tissue-specific gene expression plays a pivotal role during lineage commitment. The transcription factor c-Myb has an essential role in adult haematopoiesis and functions as an oncogene when rearranged in human cancers.
Mads Bengtsen, Kjetil Klepper, Sveinung Gundersen, Ignacio Cuervo, Finn Drabløs, Eivind Hovig, Geir Kjetil Sandve, Odd Stokke Gabrielsen, Ragnhild Eskeland   +8 more
doaj   +1 more source

Statistically Significant Strings are Related to Regulatory Elements in the Promoter Regions of Saccharomyces cerevisiae [PDF]

, 2000
Finding out statistically significant words in DNA and protein sequences forms the basis for many genetic studies. By applying the maximal entropy principle, we give one systematic way to study the nonrandom occurrence of words in DNA or protein ...
Bin Wang, Burge, Derisi, Goffeau, Helden, Hertz, Hinnebusch, Honerkamp, Lawrence, Li, Mantegna, Peng, Pevzer, Phillips, Rui Hu, Shannon, Zhang, Zhu   +17 more
core   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Identification of transcription factor binding sites in promoter databases [PDF]

, 2011
Transcription factors (TFs) are the proteins which regulates the expression of their target genes either in a positive or negative manner. TFs realize this task by binding to a specific DNA sequence contained in promoter regions, via their DNA binding ...
Dağ, Uğur, Durası, İlknur Melis, Erdoğan, Burcu, Güngör, Burcu Bakır, Kurnaz, Işıl Aksan, Sezerman, Uğur   +5 more
core   +1 more source

STarMir: a web server for prediction of microRNA binding sites

Nucleic Acids Res., 2014
STarMir web server predicts microRNA (miRNA) binding sites on a target ribonucleic acid (RNA). STarMir is an implementation of logistic prediction models developed with miRNA binding data from crosslinking immunoprecipitation (CLIP) studies (Liu,C ...
William A. Rennie, Chaochun Liu, S. Carmack, Adam Wolenc, Shaveta Kanoria, Jun Lu, Dang D. Long, Ye Ding   +7 more
semanticscholar   +1 more source