Results 21 to 30 of about 2,663,361 (333)
Journal of Lipid Research, 1972 Quantitative aspects of the binding of free fatty acid to human erythrocytes were studied by measuring the distribution of various amounts of [1-14C]lauric acid between washed human erythrocytes and defatted human plasma albumin. Incubations were done at
Arthur A. Spector +3 more
doaj +1 more source
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function. [PDF]
, 2014 The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences.
Black, Douglas L +5 more
core +4 more sources
Virus Research, 2022 The key structure of the interface between the spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human angiotensin-converting enzyme 2 (hACE2) acts as an essential switch for cell entry by the virus and drugs targets ...
Xiaopeng Hu +11 more
doaj +1 more source
Dynamics of transcription factor binding site evolution [PDF]
, 2015 Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription factors to the regulatory regions on the DNA is a key regulatory ...
Barton, Nicholas H. +3 more
core +9 more sources
Diversity of molecular targets and signaling pathways for CBD
Pharmacology Research & Perspectives, 2020 Cannabidiol (CBD) is the second most abundant component of the Cannabis plant and is known to have effects distinct from Δ9‐tetrahydrocannabinol (THC). Many studies that examined the behavioral effects of CBD concluded that it lacks the psychotomimetic ...
Douglas L. deAlmeida, Lakshmi A. Devi
doaj +1 more source
Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model [PDF]
Genomics & Informatics, 2017 Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis.
Suresh Kumar
doaj +1 more source
cAMP activates adenylate and guanylate cyclase of Dictyostelium discoideum cells by binding to different classes of cell-surface receptors. A study with extracellular Ca2+ [PDF]
, 1985 cAMP induces a transient increase of cAMP and cGMP levels in Dictyostelium discoideum cells. Fast binding experiments reveal three types of cAMP-binding site (S, H and L), which have different off-rates (t0.5, 0.7-15 s) and different affinities (Kd, 15 ...
Brachet +25 more
core +3 more sources
Using electrostatic potentials to predict DNA-binding sites on DNA-binding proteins [PDF]
, 2003 A method to detect DNA-binding sites on the surface of a protein structure is important for functional annotation. This work describes the analysis of residue patches on the surface of DNA-binding proteins and the development of a method of predicting ...
Berman, Helen M +3 more
core +4 more sources
The metal binding site of zoocin A [PDF]
JBIC Journal of Biological Inorganic Chemistry, 2008 Direct metal analysis of the bacteriolytic exoenzyme zoocin A failed to unequivocally identify a putative metal cofactor; hence, indirect experiments utilizing NMR were undertaken to settle this question. Cd(2+) as a surrogate metal ion was reconstituted into EDTA-treated, metal-free recombinant zoocin, and (113)Cd-NMR was employed to explore binding ...
Yinghua, Chen +3 more
openaire +2 more sources
Frontiers in Endocrinology, 2017 Familial dysalbuminemic hyperthyroxinemia (FDH-T4) and hypertriiodothyroninemia (FDH-T3) are dominantly inherited syndromes characterized by a high concentration of thyroid hormone in the blood stream.
Ulrich Kragh-Hansen +2 more
doaj +1 more source