Results 21 to 30 of about 1,402,076 (343)
Open Medicine, 2021 Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression when bound to specific DNA sequences. Crosstalk between steroid NR systems has been studied for understanding the development of hormone-driven cancers but ...
Cruz Maria Araceli Diaz +5 more
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A novel prediction method for protein DNA-binding residues based on neighboring residue correlations
Biotechnology & Biotechnological Equipment, 2022 Accurately identifying the protein DNA-binding residues is important for understanding the protein–DNA recognition mechanism and protein function annotation.
Jiazhi Song, Guixia Liu, Jingqing Jiang
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The metal binding site of zoocin A [PDF]
JBIC Journal of Biological Inorganic Chemistry, 2008 Direct metal analysis of the bacteriolytic exoenzyme zoocin A failed to unequivocally identify a putative metal cofactor; hence, indirect experiments utilizing NMR were undertaken to settle this question. Cd(2+) as a surrogate metal ion was reconstituted into EDTA-treated, metal-free recombinant zoocin, and (113)Cd-NMR was employed to explore binding ...
Gary L. Sloan +3 more
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Characterization and Stability of the Antimony-Quercetin Complex [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: Quercetin is a flavonoid known for its therapeutic properties and for forming complexes. Although the antimony-quercetin (SbQ) complex has been produced before, no previous exploration of its characteristics has been published in literature ...
Valcilaine Teixeira Barbosa +8 more
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Amyloid and Tau Positron Emission Tomography Imaging in Alzheimer’s Disease and Other Tauopathies
Frontiers in Aging Neuroscience, 2022 The detection and staging of Alzheimer’s disease (AD) using non-invasive imaging biomarkers is of substantial clinical importance. Positron emission tomography (PET) provides readouts to uncover molecular alterations in the brains of AD patients with ...
Cinzia Maschio, Ruiqing Ni, Ruiqing Ni
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The evolution of complex gene regulation by low specificity binding sites [PDF]
Proc. R. Soc. B 7 October 2013 vol. 280 no. 1768 20131313, 2012 Transcription factor binding sites vary in their specificity, both within and between species. Binding specificity has a strong impact on the evolution of gene expression, because it determines how easily regulatory interactions are gained and lost.
arxiv +1 more source
Frontiers in Endocrinology, 2017 Familial dysalbuminemic hyperthyroxinemia (FDH-T4) and hypertriiodothyroninemia (FDH-T3) are dominantly inherited syndromes characterized by a high concentration of thyroid hormone in the blood stream.
Ulrich Kragh-Hansen +2 more
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Direct determination of unbound lipophilic ligands in aqueous solutions [PDF]
Biological Procedures Online, 2004 Due to their hydrophobic nature, lipophilic compounds are always bound to proteins when transported in the organism. The transfer of such compounds between their binding proteins and cells as well as intracellular trafficking is mediated by a very low ...
Bojesen Inge N.
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Ethanol binding sites on proteins
Journal of Molecular Graphics and Modelling, 2017 This study is on the analysis of ethanol binding sites on 3D structures of nonredundant proteins from the Protein Data Bank. The only one amino acid residue that is significantly overrepresented around ethanol molecules is Tyr. There are usually two or more Tyr residues in the same ethanol binding site, while residues of Thr, Asp and Gln are ...
Khrustalev, V. V. +2 more
openaire +4 more sources
Molecules, 2019 The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent. Herein, we investigated the interaction of cisplatin with a 15-mer single-stranded C,T-rich oligodeoxynucleotide, 5′-CCTT4CTT7G8C9T10TCTCC-3′
Wenjuan Zeng +9 more
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