Results 41 to 50 of about 8,224,245 (384)
Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations [PDF]
, 2014 We study the effects of multiple binding sites in the promoter of a genetic oscillator. We evaluate the regulatory function of a promoter with multiple binding sites in the absence of cooperative binding, and consider different hypotheses for how the ...
Lengyel, Iván M. +3 more
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Site-Directed Mutagenesis and Site-Specific Binding Analysis of Calmodulin (CaM) [PDF]
, 2017 Calcium signaling is a major regulatory system in cells and a crucial part of cell biology. An important element in the decoding of intracellular calcium concentration into downstream processes is the ubiquitous and highly conserved calcium binding ...
Dokic, Yelena
core +1 more source
Ethanol binding sites on proteins
Journal of Molecular Graphics and Modelling, 2017 This study is on the analysis of ethanol binding sites on 3D structures of nonredundant proteins from the Protein Data Bank. The only one amino acid residue that is significantly overrepresented around ethanol molecules is Tyr. There are usually two or more Tyr residues in the same ethanol binding site, while residues of Thr, Asp and Gln are ...
Khrustalev, V. V. +2 more
openaire +4 more sources
Frontiers in Endocrinology, 2017 Familial dysalbuminemic hyperthyroxinemia (FDH-T4) and hypertriiodothyroninemia (FDH-T3) are dominantly inherited syndromes characterized by a high concentration of thyroid hormone in the blood stream.
Ulrich Kragh-Hansen +2 more
doaj +1 more source
Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors. [PDF]
, 2017 The influenza A basic polymerase protein 2 (PB2) functions as part of a heterotrimer to replicate the viral RNA genome. To investigate novel PB2 antiviral target sites, this work identified evolutionary conserved regions across the PB2 protein sequence ...
Kukol, A. +3 more
core +3 more sources
Return of the Electric Binding Site [PDF]
The Journal of General Physiology, 2008 The BK-type Ca2+-activated K+ channel has been the subject of increasingly detailed mechanistic study since the first recordings of this channel were obtained more than 25 years ago (Pallotta et al., 1981; Latorre et al., 1982; Magleby, 2003; and references therein).
openaire +2 more sources
A client‐binding site of Cdc37 [PDF]
The FEBS Journal, 2005 The molecular chaperone Hsp90 is distinct from Hsp70 and chaperonin in that client proteins are apparently restricted to a subset of proteins categorized as cellular signaling molecules. Among these, many specific protein kinases require the assistance of Hsp90 and its co‐chaperone Cdc37/p50 for their biogenesis.
Kazuya Terasawa, Yasufumi Minami
openaire +3 more sources
The evolution of complex gene regulation by low specificity binding sites
, 2012 Transcription factor binding sites vary in their specificity, both within and between species. Binding specificity has a strong impact on the evolution of gene expression, because it determines how easily regulatory interactions are gained and lost ...
Plotkin, Joshua B. +1 more
core +1 more source
Open Medicine, 2021 Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression when bound to specific DNA sequences. Crosstalk between steroid NR systems has been studied for understanding the development of hormone-driven cancers but ...
Cruz Maria Araceli Diaz +5 more
doaj +1 more source
Cis-regulatory module detection using constraint programming [PDF]
, 2010 We propose a method for finding CRMs in a set of co-regulated genes. Each CRM consists of a set of binding sites of transcription factors. We wish to find CRMs involving the same transcription factors in multiple sequences.
Guns, Tias +3 more
core +1 more source