Results 41 to 50 of about 8,121,841 (424)
PocketMatch: A new algorithm to compare binding sites in protein structures [PDF]
, 2008 Background: Recognizing similarities and deriving relationships among protein molecules is a fundamental requirement in present-day biology.
A Argyrou +25 more
core +6 more sources
Recurrent Neural Network for Predicting Transcription Factor Binding Sites
Scientific Reports, 2018 It is well known that DNA sequence contains a certain amount of transcription factors (TF) binding sites, and only part of them are identified through biological experiments. However, these experiments are expensive and time-consuming.
Zhen Shen, Wenzheng Bao, De-shuang Huang
semanticscholar +1 more source
Structural flexibility of intrinsically disordered proteins induces stepwise target recognition [PDF]
J. Chem. Phys. 139, 225103 (2013), 2013 An intrinsically disordered protein (IDP) lacks a stable three-dimensional structure, while it folds into a specific structure when it binds to a target molecule. In some IDP-target complexes, not all target binding surfaces are exposed on the outside, and intermediate states are observed in their binding processes.
arxiv +1 more source
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function. [PDF]
, 2014 The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences.
Black, Douglas L +5 more
core +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1974 With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be Pyd-A-C-C-U-C-C-U-U-A(OH). It is suggested that this region of the RNA is able to interact with mRNA and that the 3'-terminal
J. Shine, L. Dalgarno
semanticscholar +1 more source
Local sequence features that influence AP-1 cis-regulatory activity [PDF]
, 2018 In the genome, most occurrences of transcription factor binding sites (TFBS) have no cis-regulatory activity, which suggests that flanking sequences contain information that distinguishes functional from nonfunctional TFBS.
Chaudhari, Hemangi G, Cohen, Barak A
core +2 more sources
Diversity of molecular targets and signaling pathways for CBD
Pharmacology Research & Perspectives, 2020 Cannabidiol (CBD) is the second most abundant component of the Cannabis plant and is known to have effects distinct from Δ9‐tetrahydrocannabinol (THC). Many studies that examined the behavioral effects of CBD concluded that it lacks the psychotomimetic ...
Douglas L. deAlmeida, Lakshmi A. Devi
doaj +1 more source
Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model [PDF]
Genomics & Informatics, 2017 Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis.
Suresh Kumar
doaj +1 more source
Predicting effective microRNA target sites in mammalian mRNAs
eLife, 2015 MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical sites are equally effective, and both computational and in vivo UV-crosslinking approaches ...
Vikram Agarwal +3 more
semanticscholar +1 more source
Data of protein-RNA binding sites
Data in Brief, 2017 Despite the increasing number of protein-RNA complexes in structure databases, few data resources have been made available which can be readily used in developing or testing a method for predicting either protein-binding sites in RNA sequences or RNA ...
Wook Lee +3 more
doaj +1 more source