Results 61 to 70 of about 8,324,980 (383)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
MoleculesThe COVID-19 pandemic, driven by the novel coronavirus SARS-CoV-2, has drastically reshaped global health and socioeconomic landscapes. The papain-like protease (PLpro) plays a critical role in viral polyprotein cleavage and immune evasion, making it a ...
Ann Varghese +6 more
doaj +1 more source
Direct determination of unbound lipophilic ligands in aqueous solutions [PDF]
Biological Procedures Online, 2004 Due to their hydrophobic nature, lipophilic compounds are always bound to proteins when transported in the organism. The transfer of such compounds between their binding proteins and cells as well as intracellular trafficking is mediated by a very low ...
Bojesen Inge N.
doaj +1 more source
bioRxiv, 2021 The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-mediated immunity. To facilitate prospective surveillance for such evolution, we map how convalescent serum antibodies are impacted by all mutations to the spike’s ...
Allison J. Greaney +6 more
semanticscholar +1 more source
Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1 [PDF]
, 2017 Voltage-dependent anion channel-1 (VDAC1) is a highly regulated β-barrel membrane protein that mediates transport of ions and metabolites between the mitochondria and cytosol of the cell.
Abramson, Jeff +10 more
core +3 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Characterization and Stability of the Antimony-Quercetin Complex [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: Quercetin is a flavonoid known for its therapeutic properties and for forming complexes. Although the antimony-quercetin (SbQ) complex has been produced before, no previous exploration of its characteristics has been published in literature ...
Valcilaine Teixeira Barbosa +8 more
doaj +1 more source
An Overview of the Prediction of Protein DNA-Binding Sites
International Journal of Molecular Sciences, 2015 Interactions between proteins and DNA play an important role in many essential biological processes such as DNA replication, transcription, splicing, and repair.
Jingna Si, R. Zhao, R. Wu
semanticscholar +1 more source
Concerted Formation of Macromolecular \u3cem\u3eSuppressor-mutator\u3c/em\u3e Transposition Complexes [PDF]
, 1998 Transposition of the maize Suppressor-mutator (Spm) transposon requires two element-encoded proteins, TnpA and TnpD. Although there are multiple TnpA binding sites near each element end, binding of TnpA to DNA is not cooperative, and the binding affinity
Elhofy, Adam +4 more
core +1 more source
Competition from Cu(II), Zn(II) and Cd(II) in Pb(II) binding to Suwannee River Fulvic Acid [PDF]
, 2008 This is a study of trace metal competition in the complexation of Pb(II) by well-characterized humic substances, namely Suwannee River Fulvic Acid (SRFA) in model solutions.
Chakrabarti, C.L., Chakraborty, P.
core +2 more sources