Results 71 to 80 of about 8,224,245 (384)

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1*

Journal of Biological Chemistry, 1996
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is expressed when mammalian cells are subjected to hypoxia and which activates transcription of genes encoding erythropoietin, vascular endothelial growth factor ...
G. Semenza, B. Jiang, S. Leung, R. Passantino, J. Concordet, P. Maire, A. Giallongo   +6 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Concerted Formation of Macromolecular \u3cem\u3eSuppressor-mutator\u3c/em\u3e Transposition Complexes [PDF]

, 1998
Transposition of the maize Suppressor-mutator (Spm) transposon requires two element-encoded proteins, TnpA and TnpD. Although there are multiple TnpA binding sites near each element end, binding of TnpA to DNA is not cooperative, and the binding affinity
Elhofy, Adam, Fedoroff, Nina V., Karunanandaa, Balasulojini, Raina, Ramesh, Schläppi, Michael   +4 more
core   +1 more source

Competition from Cu(II), Zn(II) and Cd(II) in Pb(II) binding to Suwannee River Fulvic Acid [PDF]

, 2008
This is a study of trace metal competition in the complexation of Pb(II) by well-characterized humic substances, namely Suwannee River Fulvic Acid (SRFA) in model solutions.
Chakrabarti, C.L., Chakraborty, P.
core   +2 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

A phenotypic drug discovery approach by latent interaction in deep learning

Royal Society Open Science
Contemporary drug discovery paradigms rely heavily on binding assays about the bio-physicochemical processes. However, this dominant approach suffers from overlooked higher-order interactions arising from the intricacies of molecular mechanisms, such as ...
Tat Wai Billy Yu
doaj   +1 more source

The role of miRNA genes participating in VHL-HIF1α in clear cell renal cell carcinoma

Вестник урологии, 2019
Introduction. Much attention in ccRCC development is paid to VHL-HIF1α pathway genes. Numerous genes involved in the pathogenesis of ccRCC are targets for miRNA.
V. N. Pavlov, I. R. Gilyazova, A. A. Izmailov, E. A. Klimentova, I. R. Sultanov, M. A. Bermishev, Z. R. Akhmadeev, A. Kh. Nurgalieva, G. V. Ishbulatova, E. K. Khusnutdinova   +9 more
doaj   +1 more source

Effect of thiols on beta 2-adrenoceptors in human mononuclear leucocytes [PDF]

, 1988
The effect of the disulfide reducing agent dithiothreitol (DTT) and other thiols on binding of the beta-adrenoceptor antagonist (-)-125iodocyanopindolol (125ICYP) to human mononuclear leucocytes (MNL) was investigated.
Anhäupl, T., Haen, Ekkehard, Liebl, B., Remien, J.   +3 more
core  

RBPmap: a web server for mapping binding sites of RNA-binding proteins

Nucleic Acids Res., 2014
Regulation of gene expression is executed in many cases by RNA-binding proteins (RBPs) that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via specific binding sites on the RNA.
Inbal Paz, I. Kosti, M. Ares, M. Cline, Y. Mandel-Gutfreund   +4 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source