Results 71 to 80 of about 8,121,841 (424)

Comprehensive Analysis of Breast Cancer Cell Lines: Genome-wide Insights from ChIP-seq Analysis

Biomedical and Biotechnology Research Journal
Context: Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the central system in epigenomic exploration. Chromatin immunoprecipitation coupled with sequencing (ChIP-seq) is an important technology to identify the genome-wide location of ...
Tanishq Sahu, Ruchi Yadav
doaj   +1 more source

Binding Sites of Anti-Lcr V Monoclonal Antibodies Are More Critical than the Avidities and Affinities for Passive Protection against Yersinia pestis Infection in a Bubonic Plague Model

Antibodies, 2020
Plague is a zoonotic disease that is caused by Yersinia pestis. Monoclonal antibodies (mAbs) that bind to the V-antigen, a virulence factor that is produced by Y. pestis, can passively protect mice from plague. An analysis of protective mAbs that bind to
Kei Amemiya, Jennifer L. Dankmeyer, Sarah L. Keasey, Sylvia R. Trevino, Michael M. Wormald, Stephanie A. Halasohoris, Wilson J. Ribot, David P. Fetterer, Christopher K. Cote, Patricia L. Worsham, Jeffrey J. Adamovicz, Robert G. Ulrich   +11 more
doaj   +1 more source

Characterization and Stability of the Antimony-Quercetin Complex [PDF]

Advanced Pharmaceutical Bulletin, 2019
Purpose: Quercetin is a flavonoid known for its therapeutic properties and for forming complexes. Although the antimony-quercetin (SbQ) complex has been produced before, no previous exploration of its characteristics has been published in literature ...
Valcilaine Teixeira Barbosa, Janaína Barros de Menezes, Josué Carinhanha Caldas Santos, Maria Lysete de Assis Bastos, João Xavier de Araújo-Júnior, Ticiano Gomes do Nascimento, Irinaldo Diniz Basílio-Júnior, Luciano Aparecido Meireles Grillo, Camila Braga Dornelas   +8 more
doaj   +1 more source

Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors. [PDF]

, 2017
The influenza A basic polymerase protein 2 (PB2) functions as part of a heterotrimer to replicate the viral RNA genome. To investigate novel PB2 antiviral target sites, this work identified evolutionary conserved regions across the PB2 protein sequence ...
Kukol, A., Kukol, A., Patel, H., Patel, H.   +3 more
core   +2 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Analysis of Structures of SARS-CoV-2 Papain-like Protease Bound with Ligands Unveils Structural Features for Inhibiting the Enzyme

Molecules
The COVID-19 pandemic, driven by the novel coronavirus SARS-CoV-2, has drastically reshaped global health and socioeconomic landscapes. The papain-like protease (PLpro) plays a critical role in viral polyprotein cleavage and immune evasion, making it a ...
Ann Varghese, Jie Liu, Bailang Liu, Wenjing Guo, Fan Dong, Tucker A. Patterson, Huixiao Hong   +6 more
doaj   +1 more source

The influence of transcription factor competition on the relationship between occupancy and affinity [PDF]

PLoS ONE 8:9 (2013) e73714, 2013
Transcription factors (TFs) are proteins that bind to specific sites on the DNA and regulate gene activity. Identifying where TF molecules bind and how much time they spend on their target sites is key for understanding transcriptional regulation. It is usually assumed that the free energy of binding of a TF to the DNA (the affinity of the site) is ...
arxiv   +1 more source

Comprehensive structural classification of ligand binding motifs in proteins [PDF]

, 2008
Comprehensive knowledge of protein-ligand interactions should provide a useful basis for annotating protein functions, studying protein evolution, engineering enzymatic activity, and designing drugs.
Akira R. Kinjo, Altschul, Andreeva, Bachhawat, Barber, Berman, Berry, Beuth, Brakoulias, Carvalho, Chen, Davies, Diamond, Dias, Du, Dunn, Friedberg, Garcia-Molina, Gold, Goldstein, Gonzalez, Grishin, Grishin, Gross, Guilloteau, Gutteridge, Haruki Nakamura, Herter, Hoff, Ikura, Jonassen, Jones, Kawabata, Kawabata, Kinjo, Kinoshita, Kinoshita, Kobayashi, Kolodny, Krishna, Krishna, Krissinel, Lang, Laronde-Leblanc, Lawler, Lee, Malikayil, Minai, Murzin, Nagano, Orengo, Pattabhi, Polacco, Porter, Ridder, Rognan, Russell, Schubert, Shulman-Peleg, Standley, Stark, Stewart, Stoll, Tari, Tari, Taylor, Wallace, Wangikar, Watts, Westbrook, Whitlow, Wolfson, Xiao, Xie   +73 more
core   +2 more sources

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1*

Journal of Biological Chemistry, 1996
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is expressed when mammalian cells are subjected to hypoxia and which activates transcription of genes encoding erythropoietin, vascular endothelial growth factor ...
G. Semenza, B. Jiang, S. Leung, R. Passantino, J. Concordet, P. Maire, A. Giallongo   +6 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source