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Philip Siekevitz: Bridging biochemistry and cell biology. [PDF]
J Cell Biol, 2010 Philip Siekevitz, an Emeritus Professor at the Rockefeller University who made pioneering contributions to the development of modern cell biology, passed away on December 5th, 2009. He was a creative and enthusiastic scientist, as well as a great experimentalist who throughout his lifetime transmitted the joy of practicing science and the happiness ...
Sabatini DD.
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Biochemistry and cell biology of tau protein in neurofibrillary degeneration. [PDF]
Cold Spring Harb Perspect Med, 2012 Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD), the neurofibrillary tangles, and is therefore of major interest as an indicator of disease mechanisms. Many of the unusual properties of Tau can be explained by its nature as a natively unfolded protein.
Mandelkow EM, Mandelkow E.
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EFSA Journal, 2022 The utility of pesticides in the agricultural field is unquestionable, but at the same time pesticide use presents serious hazards to the environment and the human health.
Vasiliki Garefalaki +3 more
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Biochemistry and cell biology of bacterial endotoxins [PDF]
FEMS Immunology & Medical Microbiology, 1996 Endotoxin was first described by Richard Pfeiffer as a heat-stable, cell-associated material isolated from Vibrio cholerue [l] which induced toxic reactions in guinea-pigs. He recognized this material to be clearly distinguishable from the heat-labile exotoxins which are secreted by bacteria.
O, Holst +4 more
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Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines
npj Vaccines, 2021 Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-recognition receptors. They function as sensors of invading pathogens through recognition of pathogen-associated molecular patterns.
Rossella Sartorius +4 more
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Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles
Scientific Reports, 2022 Repurposing FDA-approved drugs is an efficient and cost-effective approach in the development of therapeutics for a broad range of diseases. However, prediction of function can be challenging, especially in the brain. We screened a small-molecule library
Sara Tucker Edmister +7 more
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Nature Communications, 2022 The colonic mucus layer is an organized system providing a physical barrier against pathogens and simultaneously harbouring the commensal flora. Here the authors report that transglutaminase 3 activity contributes to homeostasis of the colonic mucus ...
Jack D. A. Sharpen +8 more
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An 8-cage imaging system for automated analyses of mouse behavior
Scientific Reports, 2023 The analysis of mouse behavior is used in biomedical research to study brain function in health and disease. Well-established rapid assays allow for high-throughput analyses of behavior but have several drawbacks, including measurements of daytime ...
Thaís Del Rosario Hernández +4 more
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Neural Plasticity, 2022 The mammalian hippocampal dentate gyrus is a niche for adult neurogenesis from neural stem cells. Newborn neurons integrate into existing neuronal networks, where they play a key role in hippocampal functions, including learning and memory. In the ageing
Stefano Farioli-Vecchioli +2 more
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The untapped potential of plant thin cell layers [PDF]
, 2015 Thin cell layers (TCLs), which contain a small number of cells or tissues, are explants excised from different organs (stems, leaves, roots, inflorescences, flowers, cotyledons, hypocotyls/epicotyls, and embryos).
Botero Giraldo +15 more
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