Results 51 to 60 of about 989,351 (309)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Essential role of p21Waf1/Cip1 in the modulation of post-traumatic hippocampal Neural Stem Cells response

Stem Cell Research & Therapy
Background Traumatic Brain Injury (TBI) represents one of the main causes of brain damage in young people and the elderly population with a very high rate of psycho-physical disability and death.
Francesco Chiani, Valentina Mastrorilli, Nicole Marchetti, Andrea Macioce, Chiara Nappi, Georgios Strimpakos, Miriam Pasquini, Alessia Gambadoro, Jonathan Isacco Battistini, Debora Cutuli, Laura Petrosini, Sara Marinelli, Raffaella Scardigli, Stefano Farioli Vecchioli   +13 more
doaj   +1 more source

G-quadruplex Structures Contribute to Differential Radiosensitivity of the Human Genome

iScience, 2019
Summary: DNA, the fundamental unit of human cell, generally exists in Watson-Crick base-paired B-DNA form. Often, DNA folds into non-B forms, such as four-stranded G-quadruplexes.
Nitu Kumari, Supriya V. Vartak, Sumedha Dahal, Susmita Kumari, Sagar S. Desai, Vidya Gopalakrishnan, Bibha Choudhary, Sathees C. Raghavan   +7 more
doaj   +1 more source

Structure-based inhibitors of amyloid beta core suggest a common interface with tau. [PDF]

, 2019
Alzheimer's disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles which ...
Bowler, Jeannette, Cascio, Duilio, Eisenberg, David S, Glabe, Charles G, Gonen, Tamir, Griner, Sarah L, Murray, Kevin A, Philipp, Stephan, Rodriguez, Jose A, Sahay, Shruti, Sawaya, Michael R, Seidler, Paul, Sosna, Justyna, Yang, Tianxiao Peter   +13 more
core   +1 more source

Diffusion Controlled Reactions, Fluctuation Dominated Kinetics, and Living Cell Biochemistry

, 2009
In recent years considerable portion of the computer science community has focused its attention on understanding living cell biochemistry and efforts to understand such complication reaction environment have spread over wide front, ranging from systems ...
S. Barry Cooper, Vincent Danos, Zoran Konkoli   +2 more
core   +2 more sources

Micro- and nanosystems for biology and medicine [PDF]

, 2009
The development of new tools and instruments for biomedical applications based on nano- (NEMS) or microelectromechanical systems technology (MEMS) are bridging the gap between the macro- and the nano-world.
Aebi, Ueli, Akiyama, Terunobu, de Rooij, Nicolaas F., Engel, A., Frederix, P. L. T. M., Friederich, Niklaus F., Gullo, M. R., Han, A., Imer, Raphaël, Staufer, Urs, Stolz, Martin, Wirz, Dieter   +11 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Inhibitors of sterol synthesis. Submicromolar 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol causes a major modification of the sterol composition of CHO-K1 cells and a marked change in cell morphology.

Journal of Lipid Research, 1994
Incubation of Chinese hamster ovary cells (CHO-K1) with 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol (0.1 microM) in lipid-deficient medium led to a major change in cellular sterol composition, which was characterized by a very marked ...
A Izumi, F.D Pinkerton, S.O Nelson, J.S Pyrek, P.J Neill, J H Smith, G.J Schroepfer, Jr   +6 more
doaj   +1 more source

Biochemistry and cell biology of silica formation in sponges [PDF]

Microscopy Research and Technique, 2003
AbstractThe main inorganic material forming the skeletal elements in Demospongiae as well as in Hexactinellida, the spicules, is amorphous silica. The spicules occur in the cytoplasm and the extracellular space and also in the nucleus (as silicate crystals) of some sponge cells; the function in the latter compartment is unknown.
Werner E G, Müller, Anatoli, Krasko, Gaël, Le Pennec, Heinz C, Schröder   +3 more
openaire   +2 more sources