FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. [PDF]
, 2019 Wnt signalling drives many processes in development, homeostasis and disease; however, the role and mechanism of individual ligand-receptor (Wnt-Frizzled (Fzd)) interactions in specific biological processes remain poorly understood. Wnt9a is specifically
Barahona, Rocio +14 more
core
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Applications Of Microspectroscopy, Hyperspectral Chemical Imaging And Fluorescence Microscopy In Chemistry, Biochemistry, Biotechnology, Molecular And Cell Biology [PDF]
, 2011 Chemical imaging is a technique for the simultaneous measurement of spectra (chemical information) and images or pictures (spatial information)^1,2^. The technique is most often applied to either solid or gel samples, and has applications in chemistry ...
I. C. Baianu
core +1 more source
Micro- and nanosystems for biology and medicine [PDF]
, 2009 The development of new tools and instruments for biomedical applications based on nano- (NEMS) or microelectromechanical systems technology (MEMS) are bridging the gap between the macro- and the nano-world.
Aebi, Ueli +11 more
core +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. [PDF]
This research was originally published in The Journal of Biological Chemistry. Noriko Toyama-Sorimachi, Hiroyuki Sorimachi, Yoshimi Tobita, Fujiko Kitamura, Hideo Yagita, Koichi Suzuki and Masayuki Miyasaka.
ソリマチ, ノリコ, 反町, 典子
core +1 more source
LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. [PDF]
, 2014 Transcriptional elongation by RNA polymerase (Pol) II is essential for gene expression during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) stimulates transcriptional elongation by phosphorylating Pol II and ...
Ji, Xiaodan +3 more
core +2 more sources
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Determining cellular CTCF and cohesin abundances to constrain 3D genome models. [PDF]
, 2019 Achieving a quantitative and predictive understanding of 3D genome architecture remains a major challenge, as it requires quantitative measurements of the key proteins involved.
Cattoglio, Claudia +11 more
core +2 more sources