Results 61 to 70 of about 956,419 (320)
Timing and cell specificity of senescence drives postnatal lung development and injury
Nature Communications, 2023 Senescence causes age-related diseases and stress-related injury, but it is also physiologically essential during development. Here, Yao et al. show that programmed senescence in mesenchymal cells orchestrates postnatal lung development and that neonatal
Hongwei Yao +13 more
doaj +1 more source
Pandemic Teaching: Creating and teaching cell biology labs online during COVID‐19
Biochemistry and Molecular Biology Education, 2020 The year 2020 will forever be remembered as a season of pandemic teaching due to rising COVID‐19 infections. Institutions of higher learning abruptly changed from in‐person to online in attempts to minimize COVID‐19 spread.
Tracie Delgado +2 more
semanticscholar +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Robust persistence and permanence of polynomial and power law dynamical systems
, 2017 A persistent dynamical system in $\mathbb{R}^d_{> 0}$ is one whose solutions have positive lower bounds for large $t$, while a permanent dynamical system in $\mathbb{R}^d_{> 0}$ is one whose solutions have uniform upper and lower bounds for large $t ...
Brunner, James D., Craciun, Gheorghe
core +1 more source
A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells. [PDF]
, 2015 Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors.
Bucko, Paula +8 more
core +1 more source
Stem Cell Research & TherapyBackground Traumatic Brain Injury (TBI) represents one of the main causes of brain damage in young people and the elderly population with a very high rate of psycho-physical disability and death.
Francesco Chiani +13 more
doaj +1 more source
mBio, 2023 JC polyomavirus (JCPyV) is a ubiquitous, double-stranded DNA virus that causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) in immunocompromised patients. Current treatments for PML are limited to immune reconstitution,
Jacob Kaiserman +5 more
doaj +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
An unfolded protein-induced conformational switch activates mammalian IRE1. [PDF]
, 2017 The unfolded protein response (UPR) adjusts the cell's protein folding capacity in the endoplasmic reticulum (ER) according to need. IRE1 is the most conserved UPR sensor in eukaryotic cells.
Acosta-Alvear, Diego +5 more
core +3 more sources
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source