Results 11 to 20 of about 1,493,364 (293)
Practical Methods in Biochemistry [PDF]
Postgraduate Medical Journal, 1938 "Although this manual is intended primarily as the practical companion to Professor A. P. Mathews' textbook, nevertheless it contains considerable explanatory matter in order to help correlate the theoretical and laboratory aspects of the subject matter."--Pref. ; Half-title to part III not included in the paging. ; Bibliographical footnotes. ; Mode of
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iScience, 2021 Summary: Protein-protein interactions (PPIs) are of fundamental importance for our understanding of physiology and pathology. PPIs involving short, linear motifs play a major role in immunological recognition, signaling, and regulation and provide ...
Clemens Schulte +6 more
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Decoding gut microbiota by imaging analysis of fecal samples
iScience, 2021 Summary: The gut microbiota plays a crucial role in maintaining health. Monitoring the complex dynamics of its microbial population is, therefore, important. Here, we present a deep convolution network that can characterize the dynamic changes in the gut
Chikara Furusawa +5 more
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iScience, 2021 Summary: Advanced fluorescence microscopy studies require specific and monovalent molecular labeling with bright and photostable fluorophores. This necessity led to the widespread use of fluorescently labeled nanobodies against commonly employed ...
Falk Schneider +3 more
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Photocage-Selective Capture and Light-Controlled Release of Target Proteins
iScience, 2020 Summary: Photochemical transformations enable exquisite spatiotemporal control over biochemical processes; however, methods for reliable manipulations of biomolecules tagged with biocompatible photo-sensitive reporters are lacking. Here we created a high-
Rasa Rakauskaitė +8 more
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iScience, 2023 Summary: Protein interaction networks underlie countless biological mechanisms. However, most protein interaction predictions are based on biological evidence that are biased to well-known protein interaction or physical evidence that exhibits low ...
Juyoung Choi
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iScience, 2021 Summary: Chemical modification on mRNA can recruit specific binding proteins (readers/partners) to determine post-transcriptional gene regulation. However, the identification of the reader is extremely limited owing to the rather weak and highly dynamic ...
Yepei Huang +9 more
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The forbidden band and size selectivity of acoustic radiation force trapping
iScience, 2021 Summary: Acoustic micro-beams produced by highly focused ultrasound transducer have been investigated for micro-particle and cell manipulation. Here we report the selective trapping of microspheres via the acoustic force using the single acoustical beam.
Zhaoxi Li +11 more
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Identification of Small Molecules that Modulate Mutant p53 Condensation
iScience, 2020 Summary: Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions ...
Clara Lemos +21 more
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Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target
iScience, 2023 Summary: KRAS inhibitor AMG510 covalently modifies the G12C residue and inactivates the KRAS/G12C function. Because there are many reactive cysteines in the proteome, it is important to characterize AMG510 on-target modification and off-targets. Here, we
Yini Wang +14 more
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