Results 21 to 30 of about 1,093 (175)

ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

iScience, 2020
Summary: The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors ATF4, ATF6, and XBP1 within a complex network of three main branches.
Huan Yang, Marije Niemeijer, Bob van de Water, Joost B. Beltman   +3 more
doaj   +1 more source

COOBoostR: An Extreme Gradient Boosting-Based Tool for Robust Tissue or Cell-of-Origin Prediction of Tumors

Life, 2022
We present here COOBoostR, a computational method designed for the putative prediction of the tissue- or cell-of-origin of various cancer types. COOBoostR leverages regional somatic mutation density information and chromatin mark features to be applied ...
Sungmin Yang, Kyungsik Ha, Woojeung Song, Masashi Fujita, Kirsten Kübler, Paz Polak, Eiso Hiyama, Hidewaki Nakagawa, Hong-Gee Kim, Hwajin Lee   +9 more
doaj   +1 more source

The role of antigen expression in shaping the repertoire of HLA presented ligands

iScience, 2022
Summary: Human leukocyte antigen (HLA) presentation of peptides is a prerequisite of T cell immune activation. The understanding of the rules defining this event has large implications for our knowledge of basic immunology and for the rational design of ...
Heli M. Garcia Alvarez, Zeynep Koşaloğlu-Yalçın, Bjoern Peters, Morten Nielsen   +3 more
doaj   +1 more source

Inferring Disease-Associated MicroRNAs Using Semi-supervised Multi-Label Graph Convolutional Networks

iScience, 2019
Summary: MicroRNAs (miRNAs) play crucial roles in biological processes involved in diseases. The associations between diseases and protein-coding genes (PCGs) have been well investigated, and miRNAs interact with PCGs to trigger them to be functional. We
Xiaoyong Pan, Hong-Bin Shen
doaj   +1 more source

Comprehensive Targeted and Quantitative Profiling of the Human Milk Metabolome: Impact of Delivery Mode, Breastfeeding Practices, and Maternal Diet. [PDF]

Mol Nutr Food Res
Human milk (HM) is a complex fluid rich in nutrients and bioactive compounds. This study analysed the HM metabolite profile of 123 healthy women and detected 432 different metabolites. These metabolites were clustered into three distinct groups, mainly driven by differences in triglyceride concentrations. C‐section, breastfeeding practices and maternal
Calvo-Lerma J, Cabrera-Rubio R, Lerin C, González S, Selma-Royo M, Martínez-Costa C, Bottiglieri T, Collado MC.   +7 more
europepmc   +2 more sources

Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level. [PDF]

, 2018
‘A picture is worth a thousand words’ is an idiom from the English language (‘borrowed’ from on old Chinese proverb) that conveys the notion that a complex idea can be succinctly and fully described by a single image. Never has this expression been truer
Andrén, PE, Caprioli, RM, Castellino, S, Charkoftaki, G, Duncan, MW, Goodwin, RJA, Johnson, CH, Rattray, NJW, Schey, KL, Shahidi-Latham, SK, Vasiliou, V, Veselkov, KA   +11 more
core   +3 more sources

Smart DNA sensors‐based molecular identification for cancer subtyping

Smart Molecules, Volume 1, Issue 3, December 2023., 2023
Molecular subtyping of cancer is crucial for understanding the development of disease and predicting tumor behavior. This review focuses on the advanced strategies of molecular subtyping using DNA‐based biosensors for the identification of cancer subtypes based on different biomarkers, including cells, extracellular vesicles (EVs), and microRNAs ...
Yingying Gao, Mengyi Xiong, Chaonan Gong, Bo Wang, Longwei Bai, Xiao‐Bing Zhang   +5 more
wiley   +1 more source

Combination Drug Therapy of Glioblastoma: Lessons from 3D In Vitro Models and the Roadmap for Future Research

Advanced Therapeutics, Volume 6, Issue 11, November 2023., 2023
Combination drug therapy for glioblastoma (GB) offers a promising approach to target disease‐driving pathways not efficiently addressed by standard treatments. This review explores the application of 3D in vitro models of GB as testbeds for complex brain cancer pharmacological research.
Mahsa Vaezzadeh, Ehsan Kachooei, Shivani Krishnamurthy, Preeti Manandhar, Annemarie Nadort, Gilles J Guillemin, Antonio Di Ieva, Marina Santiago, Benjamin Heng, Anna Guller   +9 more
wiley   +1 more source

Insect-Inspired Sequential Inspection Strategy Enables an Artificial Network of Four Neurons to Estimate Numerosity

iScience, 2019
Summary: Varying levels of numerical cognition have been found in several animal species. Bees, in particular, have been argued to be able to count up to four items and solve complex numerical tasks.
Vera Vasas, Lars Chittka
doaj   +1 more source

MRI-based deep learning model predicts distant metastasis and chemotherapy benefit in stage II nasopharyngeal carcinoma

iScience, 2023
Summary: Chemotherapy remains controversial for stage II nasopharyngeal carcinoma because of its considerable prognostic heterogeneity. We aimed to develop an MRI-based deep learning model for predicting distant metastasis and assessing chemotherapy ...
Yu-Jun Hu, Lin Zhang, You-Ping Xiao, Tian-Zhu Lu, Qiao-Juan Guo, Shao-Jun Lin, Lan Liu, Yun-Bin Chen, Zi-Lu Huang, Ya Liu, Yong Su, Li-Zhi Liu, Xiao-Chang Gong, Jian-Ji Pan, Jin-Gao Li, Yun-Fei Xia   +15 more
doaj   +1 more source