Results 31 to 40 of about 1,093 (175)

Pan-genomic matching statistics for targeted nanopore sequencing

iScience, 2021
Summary: Nanopore sequencing is an increasingly powerful tool for genomics. Recently, computational advances have allowed nanopores to sequence in a targeted fashion; as the sequencer emits data, software can analyze the data in real time and signal the ...
Omar Ahmed, Massimiliano Rossi, Sam Kovaka, Michael C. Schatz, Travis Gagie, Christina Boucher, Ben Langmead   +6 more
doaj   +1 more source

Long non-coding RNAs: The key players in glioma pathogenesis [PDF]

, 2015
published_or_final_versio
Kiang, KMY, Leung, GKK, Zhang, XQ
core   +2 more sources

Population dynamics of rhesus macaques and associated foamy virus in Bangladesh. [PDF]

, 2013
Foamy viruses are complex retroviruses that have been shown to be transmitted from nonhuman primates to humans. In Bangladesh, infection with simian foamy virus (SFV) is ubiquitous among rhesus macaques, which come into contact with humans in diverse ...
Andreina Pacheco, M, Barry, Peter A, Craig, Karen L, Engel, Gregory A, Escalante, Ananias A, Feeroz, Mostafa M, Jackson, Dana L, Jones-Engel, Lisa, Kamrul Hasan, M, Lee, Eun-Gyung, Lerche, Nicholas W, Levine, Kathryn L, Linial, Maxine L, Matsen Iv, Frederick A, Oh, Gunwha, Rabiul Alam, SM, Small, Christopher T, Soliven, Khanh, Wang, Xiaoxing, Yee, JoAnn L   +19 more
core   +1 more source

Inferring direction of associations between histone modifications using a neural processes-based framework

iScience, 2023
Summary: Current technologies do not allow predicting interactions between histone post-translational modifications (HPTMs) at a system-level. We describe a computational framework, imputation-followed-by-inference, to predict directed association ...
Ananthakrishnan Ganesan, Denis Dermadi, Laurynas Kalesinskas, Michele Donato, Rosalie Sowers, Paul J. Utz, Purvesh Khatri   +6 more
doaj   +1 more source

Virome assembly and annotation: A surprise in the Namib Desert [PDF]

, 2017
Sequencing, assembly, and annotation of environmental virome samples is challenging. Methodological biases and differences in species abundance result in fragmentary read coverage; sequence reconstruction is further complicated by the mosaic nature of ...
Ackermann, Adriaenssens, Adriaenssens, Baker, Bankevich, Boisvert, Camacho, Carlos, Carvalhais, Clark, Crecchio, Dayaram, de Cárcer, Džunková, Eckardt, Eckardt, Efrony, Enault, Fenner, Fierer, Fuhrman, García-López, Ge, Goudie, Grande, Grande, Hannigan, Hansen, Hatfull, Hosoya, Hurwitz, Huson, Jean, Katoh, Kim, Kimura, Kraberger, Krupovic, Kurtz, Labonté, Laffy, Langmead, Letunic, Lorenzi, Lusk, Makhalanyane, Mao, McDaniel, Meyer, Minot, Mohiuddin, Nguyen, Nicholson, Peng, Peng, Pointing, Prestel, Prestel, Prigent, Rambaut, Rawlings, Richter, Rosario, Roux, Roux, Roux, Schmieder, Simpson, Solonenko, Stadelmann, Stamatakis, Sullivan, Tangherlini, Thompson, Tveit, van Dijk, Vikram, Vázquez-Castellanos, Weynberg, Wommack, Wright, Yi, Yuan, Zablocki, Zablocki   +84 more
core   +2 more sources

RetroSnake: A modular pipeline to detect human endogenous retroviruses in genome sequencing data

iScience, 2022
Summary: Human endogenous retroviruses (HERVs) integrated into the human genome as a result of ancient exogenous infections and currently comprise ∼8% of our genome.
Renata Kabiljo, Harry Bowles, Heather Marriott, Ashley R. Jones, Clement R. Bouton, Richard J.B. Dobson, John P. Quinn, Ahmad Al Khleifat, Chad M. Swanson, Ammar Al-Chalabi, Alfredo Iacoangeli   +10 more
doaj   +1 more source

Analysis of variants in the HCN4 gene and in three single nucleotide polymorphisms of the CYP3A4 gene for association with ivabradine reduction in heart rate: a preliminary report [PDF]

, 2016
[Abstract] Background: Ivabradine, a selective bradycardic drug, inhibits the If. In patients with heart failure (HF), ivabradine reduces the risk of rehospitalization and mortality.
Barge-Caballero, Eduardo, Crespo-Leiro, María Generosa, Grille Cancela, Zulaika, Hermida-Prieto, Manuel, Marrón Liñares, Grecia Manuela, Marzoa Rivas, Raquel, Muñiz, Javier, Núñez, Lucía, Paniagua-Martín, María J., Suárez-Fuentetaja, Natalia, Vázquez-Rodríguez, José Manuel   +10 more
core   +2 more sources

Integration testing of heterotic systems [PDF]

, 2014
Computational theory and practice generally focus on single-paradigm systems, but relatively little is known about how best to combine components based on radically different approaches (e.g. silicon chips and wetware) into a single coherent system.
Bălănescu T, Eilenberg S, Gaudel M-C, Gheorghe M, Gheorghe M, Gheorghe M, Holcombe M, Kendon V, Lämmel R, Merayo MG, Pezzè M, Stannett M, Stepney S   +12 more
core   +3 more sources

The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism [PDF]

, 2012
Skeletal muscle exhibits a high plasticity and accordingly can quickly adapt to different physiological and pathological stimuli by changing its phenotype largely through diverse epigenetic mechanisms.
Pérez-Schindler, Joaquín, Summermatter, Serge, Salatino, Silvia, Zorzato, Francesco, Beer, Markus, Balwierz, Piotr J., van Nimwegen, Erik, Feige, Jérôme N., Auwerx, Johan, Handschin, Christoph   +9 more
core   +5 more sources

SCING: Inference of robust, interpretable gene regulatory networks from single cell and spatial transcriptomics

iScience, 2023
Summary: Gene regulatory network (GRN) inference is an integral part of understanding physiology and disease. Single cell/nuclei RNA-seq (scRNA-seq/snRNA-seq) data has been used to elucidate cell-type GRNs; however, the accuracy and speed of current ...
Russell Littman, Michael Cheng, Ning Wang, Chao Peng, Xia Yang   +4 more
doaj   +1 more source