Results 41 to 50 of about 1,093 (175)

Ceruloplasmin expression by human peripheral blood lymphocytes: a new link between immunity and iron metabolism [PDF]

, 2008
Ceruloplasmin (CP) is a multicopper oxidase involved in the acute phase reaction to stress. Although the physiological role of CP is uncertain, its role in iron (Fe) homeostasis and protection against free radical-initiated cell injury has been widely ...
Akbar, Akbar, Aldred, Babu, Babu, Bala, Bomford, Bourbon, Cairo, Camacho, Cardoso, Cousins, Cruz, Daimon, De Sousa, de Sousa, de Sousa, Deborah Penque, Del Rey, Dina Pereira, Dorner, Eleonora Paixão, Feder, Fleming, Fortna, Fox, Frieden, Gerhard, Gitlin, Giustiniani, Goldstein, Graf, Hall, Harris, Hellman, Hellman, Itoh, Jaeger, João Banha, Klebanoff, Klomp, Knekt, Laine, Liliana Marques, Luciana Costa, Maria de Fátima Martins, Mazumder, Mittal, Moak, Osaki, Osaki, Pan, Patel, Patel, Phillips, Platonova, Porto, Pousset, Ramadori, Rita Oliveira, Rui Malhó, Santos, Senra Varela, Soltys, Stremmel, Van Eden, Van Snick, Weinberg, Weiss, Winnock, Yang   +70 more
core   +1 more source

MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer [PDF]

, 2021
We hypothesize that dosage compensation of critical genes arises from systems- level properties for cancer cells to withstand the negative effects of aneuploidy.
Acón, Man Sai, Arias Arias, Jorge Luis, Bravo Estupiñan, Diana, Báez Villalobos, Edwin, Geiß, Carsten, Guevara Coto, José Andrés, Mendes, Pedro, Mora Rodríguez, Rodrigo Antonio, Oses Vargas, Yendry, Oviedo Blanco, Guillermo, Quirós Barrantes, Steve, Rojas Matey, Luis Andres, Régnier Vigouroux, Anne, Segura Castillo, Andrés, Siles Canales, Francisco, Torres Calvo, Jorge, Vásquez Vargas, Gloriana   +16 more
core   +1 more source

Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics [PDF]

, 2021
To date, computational approaches have been recognized as a key component in drug design and discovery workflows. Developed to help researchers save time and reduce costs, several computational tools have been developed and implemented in the last twenty
Almerico, Anna Maria, Tutone, Marco
core   +1 more source

Quantifying the impact of physical activity on future glucose trends using machine learning

iScience, 2022
Summary: Prevention of hypoglycemia (glucose
Nichole S. Tyler, Clara Mosquera-Lopez, Gavin M. Young, Joseph El Youssef, Jessica R. Castle, Peter G. Jacobs   +5 more
doaj   +1 more source

Properties and identification of antibiotic drug targets [PDF]

, 2010
Background: We analysed 48 non-redundant antibiotic target proteins from all bacteria, 22 antibiotic target proteins from E. coli only and 4243 non-drug targets from E.
Tala M Bakheet, Andrew J Doig, MC McManus, REW Hancock, DE Brodersen, AP Carter, F Schlunzen, A Maxwell, BG Spratt, FC Tenover, KR Sakharkar, S Rey, P Hu, T Nakama, T Izard, MW Vetting, J Kim, ED Brown, A Yonath, TM Bakheet, DS Wishart, GL Wang, J Kyte, M Ashburner, K Julenius, LJ Jensen, JD Bendtsen, A Krogh, JC Wootton, JA Cuff, VN Vapnik, L Li, SY Gerdes, SF Altschul   +33 more
core   +1 more source

A Learning-Based Method for LncRNA-Disease Association Identification Combing Similarity Information and Rotation Forest

iScience, 2019
Summary: Long non-coding RNA (lncRNA) play critical roles in the occurrence and development of various diseases. The determination of the lncRNA-disease associations thus would contribute to provide new insights into the pathogenesis of the disease, the ...
Zhen-Hao Guo, Zhu-Hong You, Yan-Bin Wang, Hai-Cheng Yi, Zhan-Heng Chen   +4 more
doaj   +1 more source

Robust deep learning model for prognostic stratification of pancreatic ductal adenocarcinoma patients

iScience, 2021
Summary: A major challenge for treating patients with pancreatic ductal adenocarcinoma (PDAC) is the unpredictability of their prognoses due to high heterogeneity.
Jie Ju, Leonoor V. Wismans, Dana A.M. Mustafa, Marcel J.T. Reinders, Casper H.J. van Eijck, Andrew P. Stubbs, Yunlei Li   +6 more
doaj   +1 more source

Prediction of virus-host protein-protein interactions mediated by short linear motifs [PDF]

, 2017
Table S4. Supplement information describing the previous files. (Supplement - Prediction of Virus-Host Protein-Protein interactions based on Short Linear Motifs.pdf) available at https://figshare.com/articles/Supplement_-_Prediction_of_Virus-Host_Protein-
Andrés Becerra, Pedro A. Moreno, Victor A. Bucheli   +2 more
core   +3 more sources

Efficient methods for the quantum chemical treatment of protein structures: The effects of London-dispersion and basis-set incompleteness on peptide and water-cluster geometries [PDF]

, 2013
We demonstrate how quantum chemical Hartree-Fock (HF) or density functional theory (DFT) optimizations with small basis sets of peptide and water cluster structures are decisively improved if London-dispersion effects, the basis-set-superposition error ...
Goerigk, L, Reimers, JR
core   +1 more source

Measurement of eroded dentine tubule patency and roughness following novel dab-on or brushing abrasion [PDF]

, 2020
Objectives: To investigate the effect of dab-on or brushing of stannous-fluoride SnF2 or sodium-fluoride NaF dentifrice on eroded dentine tubule patency, surface and inter-tubular dentine roughness, using Confocal-Laser-Scanning-Microscopy (CLSM), Atomic-
Alhaij, Sana, Appleton, Paul L., Mohsen, Basim M., Olley, Ryan C.   +3 more
core   +3 more sources