Results 1 to 10 of about 66,046 (295)

Considerations in biodistribution evaluation of iPSC-derived cell therapy: A pancreatic islet cell case study [PDF]

Molecular Therapy: Methods & Clinical Development
Induced pluripotent stem cells (iPSCs) have substantial transformative potential in regenerative medicine, enabling tissue repair and restoration.
Miyu Nakayama, Yuu Moriya, Hikaru Ueno, Takeshi Watanabe, Hideki Hirabayashi, Syunsuke Yamamoto   +5 more
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In vivo targeting capacities of different nanoparticles to prostate tissues based on a mouse model of chronic bacterial prostatitis

Frontiers in Bioengineering and Biotechnology, 2022
Chronic bacterial prostatitis usually occurs in men and seriously affects the quality of life of patients. The efficacy of chronic bacterial prostatitis treatment is limited by the difficulty for free drugs (e.g., antibiotics) to penetrate the prostate ...
Ruimin Hu, Yang Yang, Guojing Song, Fuhan Zhao, Saipeng Chen, Zhansong Zhou, Jun Zheng, Wenhao Shen   +7 more
doaj   +1 more source

ROCKETS – a novel one-for-all toolbox for light sheet microscopy in drug discovery

Frontiers in Immunology, 2023
Advancing novel immunotherapy strategies requires refined tools in preclinical research to thoroughly assess drug targets, biodistribution, safety, and efficacy.
Joerg P. J. Mueller, Joerg P. J. Mueller, Michael Dobosz, Nils O’Brien, Nassri Abdoush, Anna Maria Giusti, Martin Lechmann, Franz Osl, Ann-Katrin Wolf, Ann-Katrin Wolf, Estibaliz Arellano-Viera, Haroon Shaikh, Markus Sauer, Andreas Rosenwald, Frank Herting, Pablo Umaña, Sara Colombetti, Thomas Pöschinger, Andreas Beilhack   +18 more
doaj   +1 more source

Recent advances in self-assembling redox nanoparticles as a radiation protective agent

AIMS Molecular Science, 2023
The search for potent radiation-protective drugs for clinical use continues. Studies have, so far, focused on targeting the neutralization of radiation-generated reactive oxygen species (ROS) to protect the cells against the deleterious effects of ...
Chitho P. Feliciano, Sandrine Cammas-Marion, Yukio Nagasaki   +2 more
doaj   +1 more source

A physiologically based pharmacokinetic model for V937 oncolytic virus in mice

Frontiers in Pharmacology, 2023
Introduction: Oncolytic viruses (OVs) represent a novel therapeutic strategy in oncology due to their capability to selectively infect and replicate in cancer cells, triggering a direct and/or immune-induced tumor lysis. However, the mechanisms governing
Sara Peribañez-Dominguez, Sara Peribañez-Dominguez, Zinnia P. Parra-Guillen, Zinnia P. Parra-Guillen, Tomoko Freshwater, Iñaki F. Troconiz, Iñaki F. Troconiz, Iñaki F. Troconiz   +7 more
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Synthesis, In Vitro Testing, and Biodistribution of Surfactant-Free Radioactive Nanoparticles for Cancer Treatment

Nanomaterials, 2022
New forms of cancer treatment, which are effective, have simple manufacturing processes, and easily transportable, are of the utmost necessity. In this work, a methodology for the synthesis of radioactive Gold-198 nanoparticles without the use of ...
Carla Daruich de Souza, Angelica Bueno Barbezan, Wilmmer Alexander Arcos Rosero, Sofia Nascimento dos Santos, Diego Vergaças de Sousa Carvalho, Carlos Alberto Zeituni, Emerson Soares Bernardes, Daniel Perez Vieira, Patrick Jack Spencer, Martha Simões Ribeiro, Maria Elisa Chuery Martins Rostelato   +10 more
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Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?

Nanomaterials, 2021
Nanobiotechnology is considered to be one of the fastest emerging fields. It is still a relatively new and exciting area of research with considerable potential for development.
Mahendra Rai, Avinash P. Ingle, Joanna Trzcińska-Wencel, Magdalena Wypij, Shital Bonde, Alka Yadav, Gabriela Kratošová, Patrycja Golińska   +7 more
doaj   +1 more source

Renal Artery Catheterization for Microcapsules’ Targeted Delivery to the Mouse Kidney

Pharmaceutics, 2022
The problem of reducing the side effects associated with drug distribution throughout the body in the treatment of various kidney diseases can be solved by effective targeted drug delivery.
Olga I. Gusliakova, Ekaterina S. Prikhozhdenko, Valentina O. Plastun, Oksana A. Mayorova, Natalia A. Shushunova, Arkady S. Abdurashitov, Oleg A. Kulikov, Maxim A. Abakumov, Dmitry A. Gorin, Gleb B. Sukhorukov, Olga A. Sindeeva   +10 more
doaj   +1 more source

Synthesis, radiolabeling, and evaluation of a (4-quinolinoyl)glycyl-2-cyanopyrrolidine analogue for fibroblast activation protein (FAP) PET imaging

Frontiers in Bioengineering and Biotechnology, 2023
Fibroblast activation protein (FAP) is regarded as a promising target for the diagnosis and treatment of tumors as it was overexpressed in cancer-associated fibroblasts.
Ni Zhang, Ni Zhang, Fei Pan, Lili Pan, Wei Diao, Feijing Su, Rui Huang, Bo Yang, Bo Yang, Yunchun Li, Zhongzhi Qi, Wenjie Zhang, Xiaoai Wu   +12 more
doaj   +1 more source

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Biomedicines, 2023
The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target.
Peter I. Parry, Astrid Lefringhausen, Conny Turni, Christopher J. Neil, Robyn Cosford, Nicholas J. Hudson, Julian Gillespie   +6 more
doaj   +1 more source