Results 11 to 20 of about 1,454,527 (262)

Crystal Structure of a Proteolytic Fragment of the Sensor Histidine Kinase NarQ

Crystals, 2020
Two-component signaling systems (TCSs) are a large and important class of sensory systems in bacteria, archaea, and some eukaryotes, yet their mechanism of action is still not fully understood from the structural point of view.
Ivan Gushchin, Igor Melnikov, Vitaly Polovinkin, Andrii Ishchenko, Valentin Gordeliy   +4 more
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Raman Scattering: From Structural Biology to Medical Applications

Crystals, 2020
This is a review of relevant Raman spectroscopy (RS) techniques and their use in structural biology, biophysics, cells, and tissues imaging towards development of various medical diagnostic tools, drug design, and other medical applications.
Alexey V. Vlasov, Nina L. Maliar, Sergey V. Bazhenov, Evelina I. Nikelshparg, Nadezda A. Brazhe, Anastasiia D. Vlasova, Stepan D. Osipov, Vsevolod V. Sudarev, Yury L. Ryzhykau, Andrey O. Bogorodskiy, Egor V. Zinovev, Andrey V. Rogachev, Ilya V. Manukhov, Valentin I. Borshchevskiy, Alexander I. Kuklin, Jan Pokorný, Olga Sosnovtseva, Georgy V. Maksimov, Valentin I. Gordeliy   +18 more
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Molecular mechanism of light-driven sodium pumping

Nature Communications, 2020
The Na+-pumping KR2 rhodopsin from Krokinobacter eikastus is a light-driven non-proton cation pump whose mechanism of pumping remains to be understood. Here authors solved crystal structures of the O-intermediate state of the pentameric form of KR2 and ...
Kirill Kovalev, Roman Astashkin, Ivan Gushchin, Philipp Orekhov, Dmytro Volkov, Egor Zinovev, Egor Marin, Maksim Rulev, Alexey Alekseev, Antoine Royant, Philippe Carpentier, Svetlana Vaganova, Dmitrii Zabelskii, Christian Baeken, Ilya Sergeev, Taras Balandin, Gleb Bourenkov, Xavier Carpena, Roeland Boer, Nina Maliar, Valentin Borshchevskiy, Georg Büldt, Ernst Bamberg, Valentin Gordeliy   +23 more
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The temporary cost of dominance

eLife, 2021
In a population of wild baboons, a new way to assess biological age reveals a surprising effect of social hierarchy.
Calen P Ryan, Christopher W Kuzawa
doaj   +1 more source

Crystal Structure of the N112A Mutant of the Light-Driven Sodium Pump KR2

Crystals, 2020
The light-driven sodium pump KR2, found in 2013 in the marine bacteria Krokinobacter eikastus, serves as a model protein for the studies of the sodium-pumping microbial rhodopsins (NaRs). KR2 possesses a unique NDQ (N112, D116, and Q123) set of the amino
Nina Maliar, Kirill Kovalev, Christian Baeken, Taras Balandin, Roman Astashkin, Maksim Rulev, Alexey Alekseev, Nikolay Ilyinsky, Andrey Rogachev, Vladimir Chupin, Dmitry Dolgikh, Mikhail Kirpichnikov, Valentin Gordeliy   +12 more
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Ageing and cancer: a research gap to fill

Molecular Oncology, 2022
The complex mechanisms of ageing biology are increasingly understood. Interventions to reduce or delay ageing‐associated diseases are emerging. Cancer is one of the diseases promoted by tissue ageing.
Eric Solary, Nancy Abou‐Zeid, Fabien Calvo   +2 more
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Biological vascular age and its relationship with cardiovascular risk factors

Кардиоваскулярная терапия и профилактика, 2022
Aim. To study of the relationship between cardiovascular risk factors and biological vascular age.Material and methods. The biological vascular age was estimated using models based on the arterial wall parameters.
A. A. Akopyan, I. D. Strazhesko, V. G. Klyashtorny, I. A. Orlova   +3 more
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Biological mechanisms of ageing [PDF]

Eye, 1987
In a short review of the theories or proposed biological mechanisms of ageing it is necessary to be very selective in the ideas which are included or rejected. Although many theories of ageing are advanced in the literature a high proportion can be considered to be special cases of a previous hypothesis. No one individual theory satisfactorily explains
openaire   +2 more sources

Viral rhodopsins 1 are an unique family of light-gated cation channels

Nature Communications, 2020
Nucleocytoplasmic Large DNA Viruses (NCLDV) that infect algae encode two distinct families of microbial rhodopsins. Here, the authors characterise two proteins form the viral rhodopsin group 1 OLPVR1 and VirChR1, present the 1.4 Å crystal structure of ...
Dmitrii Zabelskii, Alexey Alekseev, Kirill Kovalev, Vladan Rankovic, Taras Balandin, Dmytro Soloviov, Dmitry Bratanov, Ekaterina Savelyeva, Elizaveta Podolyak, Dmytro Volkov, Svetlana Vaganova, Roman Astashkin, Igor Chizhov, Natalia Yutin, Maksim Rulev, Alexander Popov, Ana-Sofia Eria-Oliveira, Tatiana Rokitskaya, Thomas Mager, Yuri Antonenko, Riccardo Rosselli, Grigoriy Armeev, Konstantin Shaitan, Michel Vivaudou, Georg Büldt, Andrey Rogachev, Francisco Rodriguez-Valera, Mikhail Kirpichnikov, Tobias Moser, Andreas Offenhäusser, Dieter Willbold, Eugene Koonin, Ernst Bamberg, Valentin Gordeliy   +33 more
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Age Prediction in Healthy Subjects Using RR Intervals and Heart Rate Variability: A Pilot Study Based on Deep Learning

Applied Sciences, 2023
Autonomic cardiac regulation is affected by advancing age and can be observed by variations in R-peak to R-peak intervals (RRIs). Heart rate variability (HRV) has been investigated as a physiological marker for predicting age using machine learning ...
Kyung Hyun Lee, Sangwon Byun
doaj   +1 more source