Results 51 to 60 of about 3,274,267 (305)

Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy. [PDF]

, 2019
MotivationMultiple biological clocks govern a healthy pregnancy. These biological mechanisms produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations during the course of pregnancy.
Agard, Bruno, Aghaeepour, Nima, Ando, Kazuo, Angst, Martin S, Callahan, Benjamin, Contrepois, Kévin, Culos, Anthony, Darmstadt, Gary L, DiGiulio, Daniel B, Druzin, Maurice L, Ganio, Edward, Gaudilliere, Brice, Gaudilliere, Dyani, Ghaemi, Mohammad Sajjad, Gibbs, Ronald, Han, Xiaoyuan, Lee-McMullen, Brittany, Lehallier, Benoit, Lewis, David B, Maric, Ivana, Mcilwain, David, McNeil, Leslie, Ngo, Thuy TM, Nolan, Garry, Partovi Nia, Vahid, Quaintance, Cecele, Quake, Stephen R, Relman, David A, Robaczewska, Anna, Rosenberg-Hasson, Yael, Shaw, Gary M, Sirota, Marina, Snyder, Michael P, Stanley, Natalie, Stevenson, David K, Tanada, Athena, Tibshirani, Robert, Tingle, Martha, Tsai, Amy, Winn, Virginia D, Wise, Paul, Wong, Ronald J, Wyss-Coray, Tony   +42 more
core   +3 more sources

Biological mechanisms of ageing [PDF]

Eye, 1987
In a short review of the theories or proposed biological mechanisms of ageing it is necessary to be very selective in the ideas which are included or rejected. Although many theories of ageing are advanced in the literature a high proportion can be considered to be special cases of a previous hypothesis. No one individual theory satisfactorily explains
openaire   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Neoadjuvant therapy for breast cancer [PDF]

, 2019
Objective: To evaluate the frequency of neoadjuvant therapy (NT) in women with stage I–III breast cancer in Italy and whether it is influenced by biological characteristics, screening history, and geographic area.
Carrozzi G., Filiberti R. A., Giorgi Rossi P., Iacovacci S., Mancuso P., Mangone L., Mazzucco W., Minicozzi P., Sant M., Tagliabue G., Tumino R.   +10 more
core   +1 more source

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Biomarkers of Aging: From Primitive Organisms to Man [PDF]

, 2001
What biological changes take place as we age? Efforts by scientists to uncover the biomarkers of aging, that is, the normal phenomena of growing old, and to separate these inevitable physiologic changes from diseases and other factors.Warns that alleged "
Richard L. Sprott, Robert N. Butler
core  

Modeling the Role of the Cell Cycle in Regulating Proteus mirabilis Swarm-Colony Development

, 2005
We present models and computational results which indicate that the spatial and temporal regularity seen in Proteus mirabilis swarm-colony development is largely an expression of a sharp age of dedifferentiation in the cell cycle from motile swarmer ...
Ayati, Ayati, Ayati, Ayati, Bruce P. Ayati, Cushing, Czirók, Esipov, Hay, Medvedev, Rauprich, Williams   +11 more
core   +1 more source

On the Biological Standard of Living of Eighteenth-Century Americans: Taller, Richer, Healthier [PDF]

, 2003
This study analyses the physical stature of runaway apprentices and military deserters based on advertisements collected from 18th-century newspapers, in order to explore the biological welfare of colonial and early-national Americans.
Komlos, John
core   +2 more sources