Results 51 to 60 of about 14,620,972 (263)

Cannabidiol counters the effects of a dominant-negative pathogenic Kv7.2 variant

iScience, 2022
Summary: Epilepsy and neurodevelopmental disorders can arise from pathogenic variants of KCNQ (Kv7) channels. A patient with developmental and epileptic encephalopathy exhibited an in-frame deletion of histidine 260 on Kv7.2. Coexpression of Kv7.2 mutant
Xiaoqin Zhan, Chris Drummond-Main, Dylan Greening, Jinjing Yao, S.W.R. Chen, J.P. Appendino, P. Y. Billie Au, Ray W. Turner   +7 more
doaj   +1 more source

Uncovering Inequities: The Role of Social Determinants of Health in Hospitalized Adolescents and Young Adults With Heavy Menstrual Bleeding

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Heavy menstrual bleeding (HMB) is a common condition among adolescents and young adults (AYAs) and is the leading cause of iron deficiency anemia (IDA) in this population. Growing evidence suggests that social determinants of health (SDOH) influence menstrual bleeding patterns, access to care, and treatment. However, no studies have
Maria Carter‐Febres, Cristina Tarango, Ashley Childress, Chunyan Liu, Evan Thomas, Jennifer Pomales, Eric S. Mullins   +6 more
wiley   +1 more source

Beta-cell-specific C3 deficiency exacerbates metabolic dysregulation and insulin resistance in obesity

Molecular Metabolism
Background: C3 is highly expressed in human and rodent pancreatic islets, which secrete insulin to regulate blood glucose homeostasis. We have previously shown that cytosolic C3 protects pancreatic beta-cells from stress, by allowing cytoprotective ...
Ben C. King, Lucie Colineau, Julia Slaby, Olga Kolodziej, Vaishnavi Dandavate, Robin Olsson, Malin Fex, Anna M. Blom   +7 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Daily nocturnal homing reveals goal-directed navigation in a wild teleost

iScience
Summary: Understanding how free-ranging animals navigate large, low-visibility environments remains an important challenge in movement ecology. Using high-resolution acoustic telemetry, we investigated the movement behavior of adult pikeperch (Sander ...
Milan Říha, Ruben Rabaneda-Bueno, Ivan Jarić, Marie Prchalová, Petr Blabolil, Marek Šmejkal, Tomáš Jůza, Michal Tušer, Jan Kubečka, Jiří Peterka   +9 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Angiotensin II prevents the metabolic but not the transdifferentiating effect of EGF on vascular smooth muscle cells from human female donors

iScience
Summary: Vascular smooth muscle cells (VSMCs) are at the center of vascular diseases but studies on VSMCs from human females are rare and the medical need for female-specific vascular research is urgent.
Virginie Dubourg, Nasrin Akhtar, Michael Kopf, Amelie Spilker, Sigrid Mildenberger, Barbara Schreier, Gerald Schwerdt, Ronald Biemann, Ralf A. Benndorf, Michael Gekle   +9 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Biological Sciences Newsletter, Fall 2008 [PDF]

, 2008
This is the alumni newsletter for the Dept.

core  

Opioid receptor distribution in the claustrum-dorsal endopiriform complex

iScience
Summary: The claustrum and dorsal endopiriform form a subcortical structure reciprocally connected to the neocortex and enriched in opioid receptors. However, the precise cellular distribution of opioid receptors within this region remains unclear. Using
Matthew Bolger, Jesse Jackson, Anna M.W. Taylor   +2 more
doaj   +1 more source