Results 131 to 140 of about 1,215,519 (212)
A Ruthenium(CAAC‐5) Olefin Metathesis Catalyst for Bioconjugation
Angewandte Chemie International Edition, Volume 65, Issue 45, 2 November 2026.The aqueous instability of ruthenium catalysts restricts olefin metathesis in biological media. A Ru(CAAC‐5) complex bearing an aniline handle is reported that remains active under biologically relevant conditions and enables bioconjugation to proteins, peptides, and an artificial metalloenzyme, providing a robust platform for olefin metathesis in ...
Damian Alexander Graf +4 more
wiley +1 more source
Repurposing Copper(II)/THPTA as A Bioorthogonal Catalyst for Thiazolidine Bond Cleavage
Advanced ScienceMetal‐mediated chemical transformations are promising approaches to manipulate and regulate proteins in fundamental biological research and therapeutic development.
Chengyun Ma +10 more
doaj +1 more source
Targeted Protein Degradation: From Molecular Mechanisms to Emerging Therapeutic Strategies
MedComm, Volume 7, Issue 11, November 2026.Graphical overview of targeted protein degradation: mechanisms, molecular determinants, delivery strategies, and therapeutic development. This graphical abstract summarizes the major degradation pathways involved in targeted protein degradation, including the ubiquitin–proteasome system, endocytosis–lysosome pathway, and autophagy‐dependent degradation.
Huaijuan Guo +8 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy +7 more
wiley +2 more sources
Strain-Promoted Bioorthogonal Chemistry
Strain-promoted bioorthogonal reactions, driven by cycloalkynes and cycloalkenes, have become indispensable in chemical biology. These strained chemical tools enable selective bioorthogonal ligations and bond-cleavage reactions, supporting research and ...
Schiefer, Andrea +2 more
core +1 more source
, 2018 A class of O2-alkyl derived diazeniumdiolates 3a–f and 4a–c were designed and synthesized as new bioorthogonal NO precursors, which can be effectively uncaged in the presence of a palladium catalyst via bioorthogonal bond cleavage reactions to generate ...
Fenghua Kang (1585186) +7 more
core +1 more source
Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes [PDF]
Bioorthogonal bond-cleavage reactions have emerged as a powerful tool for precise spatiotemporal control of (bio)molecular function in the biological context.
Walter, Kuba +13 more
core +2 more sources
Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology
European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau +3 more
wiley +1 more source
Labeling of Proteins and DNA with Strained Ring Functionality for use in Bioorthogonal Reactions
, 2011 Dr. James Wollack, Associate Professor of Chemistry, and SCU chemistry students Kristina Poss, Holly Schwarzbauer and Klara Zelikman received a $30,995 award from the 3M Large Scale Grant program to study bioorthogonal reactions.
Poss, Kristina +3 more
core
Visible Light-Initiated Bioorthogonal Photoclick Cycloaddition
, 2018 Here we report a visible light-triggered, catalyst free bioorthogonal reaction that proceeds via a distinct pathway from reported bioorthogonal reactions. The prototype of this bioorthogonal reaction was the photocycloaddition of 9,10-phenanthrenequinone
Lei Huang +15 more
core +1 more source