Results 111 to 120 of about 1,215,519 (212)

Fluorogenic iminosydnones: bioorthogonal tools for double turn-on click-and-release reactions

, 2020
International audienceIn this article, we report the synthesis and use of iminosydnone-based profluorophores as bioorthogonal cleavable linkers for imaging applications.
Taran, Frédéric, Porte, Karine, Wijkhuisen, Anne, Riomet, Margaux, Audisio, Davide   +4 more
core   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

1,2,4-Triazines Are Versatile Bioorthogonal Reagents

, 2016
A new class of bioorthogonal reagents, 1,2,4-triazines, is described. These scaffolds are stable in biological media and capable of robust reactivity with trans-cyclooctene (TCO).
Ryan A. Mehl (1313565), Jennifer A. Prescher (1616638), David N. Kamber (1668157), K. N. Houk (1247004), Yong Liang (131898), Robert J. Blizzard (1668154), Fang Liu (13271)   +6 more
core   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Bioorthogonal “Click” Cycloadditions: A Toolkit for Modulating Polymers and Nanostructures in Living Systems

Reactions
“Click” cycloadditions offer effective pathways for the modifications of supramolecular structures, polymers, and nanomaterials. These reactions include bioorthogonal mechanisms that do not interfere with the biological processes, providing a type of ...
Irene Lepori, Yavuz Oz, Jungkyun Im, Nandan Ghosh, Mohuya Paul, Ulrich S. Schubert, Stefano Fedeli   +6 more
doaj   +1 more source

Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions.

, 2020
Cleavage of C-O and C-N bonds mediated by transition metals is a promising bioorthogonal approach to rescue the activity of caged molecules, such as proteins and cytotoxic drugs, under biological conditions.
Bernardes, GJL, Latocheski, E, Domingos, JB, Dal Forno, GM, Ferreira, TM, Oliveira, BL, ,   +6 more
core  

Construction optimization and functional applications of fluorescent nanodiamonds

Responsive Materials, EarlyView.
This review summarizes synthesis, surface modification and optical properties of fluorescent nanodiamonds. Their advances in quantum sensing, single‐photon emission and biomedicine are discussed, and existing challenges and future directions are presented.
Yunpeng Yang, Sen Zhang, Chao Chen, Wensi Yang, Zuanquan Chen, Rui Fan, Linlin Liu, Benjian Liu, Kang Liu, Zhibo Zhang, Bing Dai, Jiaqi Zhu   +11 more
wiley   +1 more source

Click Chemistry and Bioorthogonal Reaction for Aggregation‐Induced Emission Bioconjugates

Aggregate
The resulting product of biocoupling is a bioconjugate, typically formed by linking molecules to proteins, oligosaccharides, nucleic acids, or synthetic polymers.
Xinzhe Yang, Miaomiao Kang, Dong Wang, Ben Zhong Tang   +3 more
doaj   +1 more source

Preparation of Protein Lysates Using Biorthogonal Chemical Reporters for Click Reaction and in-Gel Fluorescence Analysis

Bio-Protocol
Bioorthogonal chemical reporters are non-native chemical handles introduced into biomolecules of living systems, typically through metabolic or protein engineering.
Yaxin Xu, Tao Peng
doaj   +1 more source

Synthesis and Evaluation of Novel Ring-Strained Noncanonical Amino Acids for Residue-Specific Bioorthogonal Reactions in Living Cells. [PDF]

Chemistry, 2021
Reinkemeier CD, Koehler C, Sauter PF, Shymanska NV, Echalier C, Rutkowska A, Will DW, Schultz C, Lemke EA.   +8 more
europepmc   +1 more source