Development of Blue‐to‐Near‐Infrared rTCO–Caged Fluorogenic Probes for Click‐to‐Release Monitoring
Chemistry – A European Journal, EarlyView.A series of fluorogenic rTCO‐caged click‐to‐release probes was prepared and evaluated both in a cuvette and in live cells. Some of the probes exhibited significant turn‐on and efficient fluorophore release spanning the blue‐to‐NIR region. A significant difference in the performance of the compounds in live cells was observed, highlighting the need for ...
Marek Chovanec +4 more
wiley +1 more source
SITE-SPECIFIC FUNCTIONALIZATION OF PROTEINS AND THEIR APPLICATIONS TO THERAPEUTIC ANTIBODIES
Computational and Structural Biotechnology Journal, 2014 Protein modifications are often required to study structure and function relationships. Instead of the random labeling of lysine residues, methods have been developed to (sequence) specific label proteins.
Remko van Vught +2 more
doaj +1 more source
User-friendly bioorthogonal reactions click to explore glycan functions in complex biological systems. [PDF]
J Clin Invest, 2023 Chen X, Varki A.
europepmc +1 more source
Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies
Chemistry – A European JournalABSTRACT Bioorthogonal chemistry has emerged as a transformative strategy for detecting and quantifying biomolecules in complex biological systems. This review highlights recent advances in catalyst‐free bioorthogonal reactions specifically applied to semi‐quantitative and quantitative biomolecular analysis.
Yang, Mingze, Wang, Shiqi
openaire +4 more sources
From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions
Accounts of Chemical Research, 2011 Bioorthogonal reactions are chemical reactions that neither interact with nor interfere with a biological system. The participating functional groups must be inert to biological moieties, must selectively reactive with each other under biocompatible conditions, and, for in vivo applications, must be nontoxic to cells and organisms.
Sletten, Ellen M., Bertozzi, Carolyn R.
openaire +2 more sources
Photocatalysis‐Triggered Click Reactions and Applications
European Journal of Organic Chemistry, EarlyView.Photoclick chemistry offers broad applications ranging from materials science to bioconjugation, with precise spatiotemporal control over click reactions. Initially limited to UV activation, recent advances have extended photoclick processes to the visible and NIR regions thanks to the photocatalysis.
Margaux Walter +2 more
wiley +1 more source
Seeking Citius: Photochemical Access of Reactive Intermediates for Faster Bioorthogonal Reactions. [PDF]
Chembiochem, 2022 Kumar GS, Lin Q.
europepmc +1 more source
Developing New Chemical Reactions that Can Be Performed in Living Cells
, 2019 The development of bioorthogonal chemical reactions-chemical reactions that can be conducted in living cells-has been one of the most significant areas of advancement in chemistry in recent years.
Franzini, R.M.
core
Development of Coupling Partners for Bioorthogonal Reactions with N-Hydroxylamines [PDF]
, 2017 Bioorthogonal chemistry enables biological chemists to study the dynamics of complex biological systems. Bioorthogonal chemistry allows the selective reaction of an orthogonal tag, which is incorporated on the molecule of interest via biosynthetic or ...
Santos, Maria Jobette
core
Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source