Results 81 to 90 of about 1,215,519 (212)

Cell-surface Labeling via Bioorthogonal HostGuest Chemistry

, 2021
The widespread adoption of the bioorthogonal chemical reporter strategy revolutionized chemical biology. However, its translation to living mammals has been challenging, due to the size/stability properties of the chemical reporter group and/or the ...
Selena Hernandez, Ellen M. Sletten (1264827), Ellen M. Sletten, Selena Hernandez (9338211), Anna Kataki-Anastasakou (9708407), Anna Kataki-Anastasakou   +5 more
core   +1 more source

Intracellular bioorthogonal chemistry [PDF]

, 2018
Bioorthogonal reactions have a central role in medicinal therapeutics and diagnostics. Extracellularly binding substances, like antibodies, are often used as targeting agents and are coupled with a bioorthogonal reaction agent.
Sporer, Emanuel
core   +1 more source

Bioorthogonal Chemistry in Neurobiology: From Imaging to Proteomics [PDF]

Chembiochem
This review highlights emerging strategies for labeling neuronal proteins, enabling visualization and quantitative analysis of their expression, localization, and dynamics. By combining genetic code expansion (GCE), metabolic labeling, and click chemistry‐based labeling, these approaches provide powerful routes to study proteins in specific cells and ...
Taylor N, de Sousa‐Lourenço J, Nikić‐Spiegel I.   +2 more
europepmc   +2 more sources

Blocked bioorthogonal chemistry enabled switchable bioorthosome to improve liposomal drug delivery for glioblastoma therapy

Nano Research
Glioblastoma (GBM) interventions necessitate exceptional precision due to the presence of blood-brain barrier (BBB) and its intricate co-growth with neuron and glial cells.
Chao Wang, Jie Wu, Zhiran Duan, Yuqing Pan, Haijing Qu, Wei Cheng, Ning Wang, Han Chen, Xiaoli Gao, Mengqing Hou, Ying Zhang, Xiangdong Xue   +11 more
doaj   +1 more source

Not So Bioorthogonal Chemistry [PDF]

The advent of bioorthogonal chemistry has transformed scientific research, offering a powerful tool for selective and noninvasive labeling of (bio)molecules within complex biological environments.
Weil, T., Schauenburg, D., Schauenburg, Dominik, Weil, Tanja   +3 more
core   +1 more source

Recent Trends in Bioorthogonal Click-Radiolabeling Reactions Using Fluorine-18

Molecules, 2013
The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of novel and versatile bioorthogonal conjugation techniques especially for the radiolabeling of biologically ...
Doreen Pietzsch, Constantin Mamat, Marc Pretze   +2 more
doaj   +1 more source

Predictive Multivariate Models for Bioorthogonal Inverse-Electron Demand Diels–Alder Reactions

, 2020
Inverse-electron demand Diels–Alder cycloadditions have emerged as important bioorthogonal reactions in chemical biology. Understanding and predicting reaction rates for bioconjugation reactions is fundamental for evaluating their efficacy in biological ...
Joao M. J. M. Ravasco, Jaime A. S. Coelho (7320095), Jaime A. S. Coelho, Joao M. J. M. Ravasco (8485806)   +3 more
core   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Living functional hydrogels generated by bioorthogonal cross-linking reactions of azide-modified cells with alkyne-modified polymers

Nature Communications, 2018
Cells are often passively encapsulated in hydrogels for a wide range of applications. Here, the authors report on a method of incorporating the cells into the hydrogel using bioorthogonal click reactions to link azide-modified cells with biocompatible ...
Koji Nagahama, Yuuka Kimura, Ayaka Takemoto   +2 more
doaj   +1 more source

Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications

Frontiers in Chemistry, 2015
Bioorthogonal chemistry has recently emerged to be one of the most powerful tools in drug discovery and chemical biology. The exploration of it has successfully advanced the field of natural product research.
Xuejun eZhu, Wenjun eZhang
doaj   +1 more source