Results 71 to 80 of about 1,215,519 (212)

Reactive oxygen species-activated bioorthogonal chemistry in living systems enabled by boronate-caged dihydrotetrazines

Nature Communications
Bioorthogonal chemistry has become a robust toolbox with growing applications in biology and medicine. To meet diverse needs in research, new types of on-demand bioorthogonal reactions capable of responding to biological triggers or exogenous stimuli are
Dongqing Ming, Jiaxue Zhang, Binsong Mu, Dongxue Peng, Yanjun Wang, Yangyang Kong, Wenjing Wang, Ling Chu, Rui Wang, Luping Liu   +9 more
doaj   +1 more source

Diels-Alder Reactions with Inverse Electron Demand and Olefin Metathesis as Potential Bioorthogonal Reactions [PDF]

This thesis explores bioorthogonal reactions, focusing on Diels-Alder reactions with inverse electron demand using symmetrical aryl tetrazines, with an emphasis on their reactivity and stability.
Ernst, Kevin
core   +1 more source

Membrane‐Targeted Nanoparticles for Neuronal Photomodulation

Advanced Science, EarlyView.
Immobilizing gold nanoparticles on the neural interface using a bioorthogonal approach generates localized heat upon exposure to near‐infrared light, temporarily inhibiting primary neuronal activity without damaging the cells. This precise placement and retention of nanoparticles at the cell membrane expand the strategies for non‐invasive neural ...
Ane Escobar, Ana Sánchez‐Iglesias, Davide Bello, Miriam Feijoo Barriga, Alex M. Ascensión, Laura Rodríguez‐Gómez, David Otaegui‐Bichot, Francisco Javier Gil‐Bea, Monica Carril, Marek Grzelczak   +9 more
wiley   +1 more source

Precision delivery of estrogen receptor antagonists using bioorthogonal chemistry-based intelligent nanocarriers to overcome cervical cancer drug resistance

Materials Today Bio
Cervical cancer remains a significant health burden among women worldwide, with drug resistance posing a major obstacle to effective treatment strategies.
Xue Yang, Yang Gu
doaj   +1 more source

Switching azide and alkyne tags on bioorthogonal reporters in metabolic labeling of sialylatedglycoconjugates: a comparative study

Scientific Reports, 2022
Sialylation of cell surface glycans plays an essential role in cell–cell interaction and communication of cells with their microenvironment. Among the tools that have been developed for the study of sialylation in living cells, metabolic oligosaccharide ...
Jodie Scache, Vincent Rigolot, Cédric Lion, Marlène Mortuaire, Tony Lefebvre, Christophe Biot, Anne-Sophie Vercoutter-Edouart   +6 more
doaj   +1 more source

Specific Modulation of Protein Activity by Using a Bioorthogonal Reaction [PDF]

ChemBioChem, 2014
Abstract Unnatural amino acids with bioorthogonal reactive groups have the potential to provide a rapid and specific mechanism for covalently inhibiting a protein of interest. Here, we use mutagenesis to insert an unnatural amino acid containing an azide group (Z) into the target protein at positions such that a ...
John B, Warner, Anand K, Muthusamy, E James, Petersson   +2 more
openaire   +2 more sources

Bioorthogonal cyclopropenones and phosphines for biomolecule investigation

, 2023
Bioorthogonal chemistries have provided methods to investigate biomolecules in their native environments with minimal effects on cellular processes. Efforts to develop new bioorthogonal reactions have equipped researchers with powerful tools to probe ...
Dorn, Robert
core   +1 more source

Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology

Advanced Science
Bioorthogonal catalysis has revolutionized the field of chemical biology by enabling selective and controlled chemical transformations within living systems.
Yan Zhang, Qizhen Huang, Fang Lei, Wanlong Qian, Chengfeng Zhang, Qi Wang, Chaoqun Liu, Haiwei Ji, Faming Wang   +8 more
doaj   +1 more source

Designed heterogeneous palladium catalysts for reversible light-controlled bioorthogonal catalysis in living cells

Nature Communications, 2018
Fine controlling chemical reactions over transition metal catalysts in living systems like enzymes remains a challenge. Here, the authors develop a versatile light-controlled bioorthogonal catalyst by modifying macroporous silica-Pd0 with supramolecular ...
Faming Wang, Yan Zhang, Zhi Du, Jinsong Ren, Xiaogang Qu   +4 more
doaj   +1 more source

Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging

, 2015
Bioorthogonal reactions, including the strain-promoted azide–alkyne cycloaddition (SPAAC) and inverse electron demand Diels–Alder (iEDDA) reactions, have become increasingly popular for live-cell imaging applications.
Edward R. Guilmette (1534633), Joseph M. Fox (1534624), Li Di (1534642), Joel W. Schwartz (377800), T. Eric Ballard (1534636), Yinzhi Fang (1534621), Heather E. Murrey (1266897), Christopher W. am Ende (1534630), Keith Riccardi (1534627), Douglas S. Johnson (1534639), Joshua C. Judkins (1534618)   +10 more
core   +1 more source