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Insight into Fluorescence Imaging and Bioorthogonal Reactions in Biological Analysis
Topics in Current Chemistry, 2021Fluorescence imaging is an important method in the field of biomedicine. Fluorescence imaging is nondestructive, has high efficiency and sensitivity, high resolution and allows real-time dynamic monitoring of living cells. However, it also has some disadvantages, such as high background signals and low selectivity.
Yuexiang Ma +3 more
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Turning on bioorthogonal reactions catalytically
C&EN Global Enterprise, 2016To attach probes for imaging to biomolecules inside cells or organisms, chemists have developed so-called bioorthogonal reactions that don’t interfere with the biochemistry of the living things. Tetrazine ligation is the fastest of these bioorthogonal reactions, and its speed allows scientists to use small amounts of reagents to get the job done. A new
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Optimized aqueous Kinugasa reactions for bioorthogonal chemistry applications
Chemical Communications, 2020We present optimized micelle-assisted aqueous copper( i )-catalyzed alkyne–nitrone cycloaddition involving rearrangement (CuANCR) reactions applicable to bioorthogonal applications, namely membrane-associated peptide modification.
Didier A. Bilodeau +5 more
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A Comparative Study of Bioorthogonal Reactions with Azides
ACS Chemical Biology, 2006Detection of metabolites and post-translational modifications can be achieved using the azide as a bioorthogonal chemical reporter. Once introduced into target biomolecules, either metabolically or through chemical modification, the azide can be tagged with probes using one of three highly selective reactions: the Staudinger ligation, the Cu(I ...
Nicholas J. Agard +4 more
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Bioorthogonal Reactions for Bioactive Sulfur Species Delivery
ChemBioChemBioorthogonal chemistry has emerged as a powerful tool for the development of controllable drug delivery systems. Bioactive sulfur species, which participate in complex sulfur signaling pathways, play crucial roles in various physiological and pathological processes.
Yinghan Chen, Lixin Xu, Yong Liang
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Inverse Electron-Demand Diels–Alder Bioorthogonal Reactions
Topics in Current Chemistry, 2015Bioorthogonal reactions have been widely used over the last 10 years for imaging, detection, diagnostics, drug delivery, and biomaterials. Tetrazine reactions are a recently developed class of inverse electron-demand Diels-Alder reactions used in bioorthogonal applications.
Haoxing, Wu, Neal K, Devaraj
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Three-Component Bioorthogonal Reactions on Cellular DNA and RNA
Bioconjugate Chemistry, 2019Metabolic incorporation of bioorthogonal functional groups into chromatin, followed by copper-free conjugation reactions, often gives low yields due to steric hindrance. Here we report that a cationic Sondheimer diyne derivative "DiMOC" rapidly reacts with azide groups in duplex DNA that are otherwise unreactive toward aliphatic cyclooctynes such as ...
Masayuki Tera, Nathan W. Luedtke
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Bioorthogonal Reaction for Fluorine-18 Labeling
2018Specific molecular imaging probes including radiopharmaceuticals labeled with positron-emitters, such as fluorine-18 (18F, t1/2 = 109.8 min), need to expand their applications of positron emission tomography (PET) molecular imaging study. In recent years, bioorthogonal chemistry such as inverse electron-demand Diels-Alder cycloaddition reactions and ...
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Target-Specific Bioorthogonal Reactions for Precise Biomedical Applications
Angewandte Chemie - International Edition, 2023Jinsong Ren, Xiaogang Qu, Mengyu Sun
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Fluorescent Probes Based on Bioorthogonal Reactions: Construction Strategies and Applications
TrAC - Trends in Analytical Chemistry, 2023Jianzhong Lu, Hanqing Zhao, Yingtung Lo
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