Results 41 to 50 of about 4,698 (199)
iMetaOmics, EarlyView.Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal +4 more
wiley +1 more source
Pteridines and Lipid Metabolism
Pteridines, 1998 The effect of 9 different pteridines on fatty acid incorporation into phospholipids as well as on cholesterol and phospholipid content was compared in vitro using rat liver homogenate, Krebs-Ringer phosphate buffer containing 0.3 % albumin (pH=7.4 ...
Rudzite Vera +5 more
doaj +1 more source
The FEBS Journal, EarlyView.The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini +6 more
wiley +1 more source
Pteridines, 2010 Biopterin as a stable metabolite is produced by oxidation of 5,6,7,8-tetrahydrobiopterin (BH4). It is known that many diseases may cause changes in BH4 concentration and/or dihydropteridine reductase (DHPR) enzyme activity. There is only a limited number
Girgin Gözde +7 more
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Evaluation of dihydropteridine reductase activities in patients with kidney failure
Pteridines, 2013 End-stage renal disease (ESRD) is the inability of the kidneys to remove waste products from the blood. The most important factors causing ESRD that require hemodialysis are diabetes and hypertension.
Palabıyık Şaziye Sezin +5 more
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Hippo Pathway Drives Durable Non‐Cell‐Autonomous Ferroptosis Resistance in Lung Cancer
Cancer Science, Volume 117, Issue 3, Page 683-694, March 2026.YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Mohamed Fathi Saleh +6 more
wiley +1 more source
Pteridines, 2017 Conjugated and unconjugated pteridines and their derivatives are important cofactors in cellular metabolism. Hence, the amount of unconjugated pteridines in biological fluids has been found to be modified as a result of several disorders. It is necessary
Espinosa-Mansilla Anunciación +1 more
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Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.
Journal of Biological Chemistry, 1989 Generation of nitric oxide (NO.), an autacoid with vasorelaxant and cytotoxic properties, requires at least three cytosolic components in mouse macrophages besides L-arginine and NADPH. One or more components appear after induction by immunologic stimuli;
N. Kwon, C. Nathan, D. Stuehr
semanticscholar +1 more source
Plasma Nitrate and Pteridine Levels in Experimental Bacteremia in Baboons
Pteridines, 1995 Using a recently developed model of bacterially induced sepsis in baboons, we studied the time courses of pteridine and nitrate levels in plasma with regard to the dose of Escherichia coli. Eight animals were given a 2 h infusion of 2X 10" Colony Forming
Strohmaier Wolfgang +4 more
doaj +1 more source
Journal of Diabetes and Metabolic Disorders, 2014 BackgroundBiopterins have a crucial role in the function of nitric oxide synthase, uncoupling of the enzyme leads to endothelial dysfunction and vascular damage, The aim of this study was to evaluate the relationship between the levels of biopterins with
A. Rubio-Guerra +6 more
semanticscholar +1 more source