Results 51 to 60 of about 4,698 (199)

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

Serum Biopterin as a Marker of Immune Activation in the Spontaneously Diabetic BB Rat

Pteridines, 1998
Tetrahydrobiopterin (BH4), is a pteridine product which is released by rodent macrophages and fibroblasts upon activation by cytokines. It has previously been reported as a potentially useful marker for monitoring immune activation during the prediabetic
Galloway Tamara, Braven Jim, Barley Jas, Rokos Hartmut, Wilkin Terence   +4 more
doaj   +1 more source

Genome‐Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms–Fish Hosts System and Drug Target Identification

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang, Jie‐Mei Zhao, Chuan‐Yu Xiang, Yi‐Wen Ma, Hong‐Peng Lei, Yu‐Ying Shi, Shun Zhou, Xiaofei Zeng, Jinsong Chen, Fei Liu, Benhe Zeng, Rui Song, Ye Hu, Feng Zhang, Xiang Liu, Wen‐Xiang Li, Gui‐Tang Wang, Ivan Jakovlić   +17 more
wiley   +1 more source

Exposure to Helicobacter pylori and Serum Kynurenine to Tryptophan Ratio in Patients with Gastric Cancer

Pteridines, 2010
In Helicobacter pylori seropositive individuals, the subsequent risk of non-cardia gastric cancer development is frequently attributed to the infection agent. Although the link between inflammation and gastric cancer is formally recognized, the molecular
Engin Ayse Basak, Karahalil Bensu, Karakaya Ali Esat, Engin Atilla   +3 more
doaj   +1 more source

Consensus Guideline for the Diagnosis and Treatment of Tyrosine Hydroxylase (TH) Deficiency

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Tyrosine hydroxylase (TH) catalyses the rate‐limiting step in dopamine biosynthesis. Autosomal recessive tyrosine hydroxylase deficiency (THD) leads to clinical phenotypes reflecting the deficiency of dopamine, norepinephrine, or epinephrine in the central nervous system (CNS), presenting along a continuous spectrum from mild to severe forms ...
Mariya Sigatullina Bondarenko, Oya Kuseyri Hübschmann, Jan Kulhánek, Roser Pons, Toni S. Pearson, Kathrin Jeltsch, Ivana Badnjarevic, Tessa Wassenberg, Gabriella Horvath, Galina Stevanovic, Manju A. Kurian, Elisenda Cortès‐Saladelafont, Agathe Roubertie, Vincenzo Leuzzi, Mariarita Bertoldi, Mario Mastrangelo, Birgit Assmann, THD Guidelines Working Group, Ines Denzler, Clarisa Maxit, Natalia Alexandra Julia‐Palacios, Shekeeb Mohammad, Helly Goez, Wai‐Ian Yeung, Tomáš Honzík, Ivana Kavecan, Alba Tristán‐Noguero, Alberto Burlina, Daniela Gueraldi, Sushil Bandodkar, Willemsen Michel, Francesco Porta, Sheila Wong, Filippo Manti, Reem Alkhater, Chris Mühlhausen, Alice Kuster, Dimitrios Zafeiriou, Paulo Sgobbi, Wladimir Bocca Vieira de Rezende Pinto, Angeles Garcia‐Cazorla, Thomas Opladen   +41 more
wiley   +1 more source

Effect of prochloraz fungicide on neopterin and biopterin concentrations in blood plasma of common carp

, 2014
Neopterin and biopterin are often used as markers of cell mediated immunity. The aim of this study was to evaluate the effect of prochloraz on neopterin and biopterin concentrations in blood plasma of common carp as possible indicators for monitoring ...
P. Marsalek, I. Mikulíková, H. Modrá, Z. Svobodová   +3 more
semanticscholar   +1 more source

Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild

American Journal of Primatology, Volume 87, Issue 10, October 2025.
Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Verena Behringer, Caroline Deimel
wiley   +1 more source

Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins

Pteridines, 1995
Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L ...
Schallreuter-Wood Karin U., Wood John M.
doaj   +1 more source

High Affinity S-Adenosylmethionine Plasma Membrane Transporter of Leishmania Is a Member of the Folate Biopterin Transporter (FBT) Family*

Journal of Biological Chemistry, 2010
S-Adenosylmethionine (AdoMet) is an important methyl group donor that plays a central role in many essential biochemical processes. The parasite Leishmania can both synthesize and transport AdoMet.
L. Dridi, A. Ahmed Ouameur, M. Ouellette
semanticscholar   +1 more source

Dissecting the genomic regions, candidate genes and pathways using multi‐locus genome‐wide association study for stem rot disease resistance in groundnut

The Plant Genome, Volume 18, Issue 3, September 2025.
Abstract Stem rot, caused by Sclerotium rolfsii Sacc., is a devastating soil‐borne disease causing up to 80% yield losses in groundnut globally. To dissect the genetic basis of resistance, we evaluated a diverse minicore germplasm panel over 3 years in stem rot sick‐field conditions.
H. V. Veerendrakumar, Hari Kishan Sudini, Bangaru Kiranmayee, Talwar Devika, Sunil S. Gangurde, R. P. Vasanthi, A. R. Nirmal Kumar, Sandip K. Bera, Baozhu Guo, Boshou Liao, Rajeev K. Varshney, Manish K. Pandey   +11 more
wiley   +1 more source