Iterative hybrid model based optimization of rAAV production
Biotechnology Progress, EarlyView.Abstract Changes in serotype or genetic payload of recombinant adeno associated virus (rAAVs) gene therapies require adapting the transfection conditions of the upstream HEK293 cultivations. This study adopts an iterative model‐based experiment design approach, where increasing data availability is leveraged to evolve models of different complexity ...
Claudio Müller +7 more
wiley +1 more source
Evaluation of hollow fiber bioreactors as an alternative to murine ascites production for small scale monoclonal antibody production [PDF]
, 1996 Lynn Jackson +3 more
openalex +1 more source
A synthetic platform for developing recombinant adeno‐associated virus type 8 producer cell lines
Biotechnology Progress, EarlyView.Abstract Recombinant adeno‐associated virus (rAAV) is one of the most widely used viral vectors for gene therapy. It is used in very high doses for the treatment of many diseases, making large‐scale production for clinical applications challenging. We have established a synthetic biology‐based platform to construct stable production cell lines, which ...
Yu‐Chieh Lin +5 more
wiley +1 more source
Charting the landscape of the environmental exposome
iMeta, Volume 1, Issue 4, December 2022., 2022 We describe the biological and chemical components of the environmental exposomes in three major environmental matrices that are highly relevant to human and social‐economical health—air, soil, and water. We discuss how different exposome components can interact with each other. Finally, we propose a list of outstanding challenges to be tackled to push
Xin Wei +6 more
wiley +1 more source
The Properties of the Multistage Bioreactor Constructed by the LB Technique
, 1991 Michihiro Ohnishi +2 more
openalex +1 more source
The mammary gland as a bioreactor: factors regulating the efficient expression of milk protein-based transgenes [PDF]
, 1996 JM Rosen +3 more
openalex +1 more source
Biotechnology Progress, EarlyView.Abstract Monitoring cell culture is crucial for gaining a deeper understanding of processes and ensuring the production of safe and high‐quality products. The capability to measure in real time several parameters of interest can be achieved with Raman spectroscopy.
Célia Sanchez +6 more
wiley +1 more source
Understanding the transfer and persistence of antimicrobial resistance in aquaculture using a model teleost gut system. [PDF]
Anim MicrobiomeBarcan AS +11 more
europepmc +2 more sources
The proteome of osteoblasts in a 3D culture perfusion bioreactor model compared with static conditions. [PDF]
Sci RepRadi S +6 more
europepmc +1 more source
Anaerobic Digestion of Sewage Sludge by Membrane Separated Bioreactor.
, 1992 Hidenori Aya, Katsuyuki NAMIKI
openalex +2 more sources