Results 91 to 100 of about 121,897 (203)

Transcriptomic signatures of neuronal differentiation and their association with risk genes for autism spectrum and related neuropsychiatric disorders. [PDF]

, 2016
Genes for autism spectrum disorders (ASDs) are also implicated in fragile X syndrome (FXS), intellectual disabilities (ID) or schizophrenia (SCZ), and converge on neuronal function and differentiation. The SH-SY5Y neuroblastoma cell line, the most widely
Chiocchetti, AG, Cocchi, E, de la Torre-Ubieta, L, Freitag, CM, Fulda, S, Geschwind, DH, Haslinger, D, Lindlar, S, Rothämel, T, Stein, JL, Waltes, R   +10 more
core   +1 more source

Organellar carbon metabolism is co-ordinated with distinct developmental phases of secondary xylem [PDF]

, 2019
Subcellular compartmentation of plant biosynthetic pathways in the mitochondria and plastids requires coordinated regulation of nuclear encoded genes, and the role of these genes has been largely ignored by wood researchers. In this study, we constructed
Fierro Gutierrez, Ana Carolina Elisa, Marchal, Kathleen, Mizrachi, Eshchar, Myburg, Alexander A, Pinard, Desré   +4 more
core   +2 more sources

Mining microbial genomes for new natural products and biosynthetic pathways [PDF]

, 2008
Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
Austin, Austin, Banskota, Banskota, Barona-Gómez, Barona-Gómez, Bentley, Bergmann, Bok, Caffrey, Chain, Challis, Challis, Challis, Challis, Chen, Chen, Corre, de Bruijn, Drake, Erb, Fischbach, Fleischmann, Fleming, Funa, Gregory L. Challis, Gross, Gross, Grüschow, Gust, Günter, Haydock, Haynes, Hojati, Hornung, Ikeda, Izumikawa, Kadi, Keller, Koehn, Larsen, Lautru, Lautru, Li, Li, Lin, Lin, McAlpine, Miethke, Minowa, Miyanaga, Muller, Nguyen, Oliynyk, Omura, Paulsen, Petersen, Pfeifer, Rausch, Reid, Song, Stachelhaus, Sudek, Tohyama, Udwary, Wilkinson, Zhao, Zirkle   +67 more
core   +2 more sources

Identification of the p-coumaric acid biosynthetic gene cluster in Kutzneria albida: insights into the diazotization-dependent deamination pathway

Beilstein Journal of Organic Chemistry
Recently, we identified the biosynthetic gene cluster of avenalumic acid (ava cluster) and revealed its entire biosynthetic pathway, resulting in the discovery of a diazotization-dependent deamination pathway.
Seiji Kawai, Akito Yamada, Yohei Katsuyama, Yasuo Ohnishi   +3 more
doaj   +1 more source

How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group? [PDF]

, 2015
This work was financially support by a Marie Curie Initial Training Network grant, “Understanding the evolutionary origin of biological diversity” (ITN-2008–213780 SPECIATION), grants from the Academy of Finland to A.H.
A Hoikkala, A Laiho, A Martin, A Sasson, AA Hoffmann, AL Majumder, AR McCune, B Katz, BJ Sinclair, C Canestro, CJ Reaume, CP Downes, D Arbuthnott, D Bell-Pedersen, D J Parker, DW Huang, DW Huang, FA Loewus, H Colinet, H Colinet, HA MacMillan, J Overgaard, J Zhang, JR Hazel, K Xu, KB Storey, KY Xu, L Kivivuori, L Vesala, L Vesala, L Vesala, LH Throckmorton, M G Ritchie, M Kankare, M Kim, M Reis, M Watanabe, M Watanabe, MC Magnone, MD Robinson, MD Robinson, MJ Fitzpatrick, MK Jones, MV Rockman, NM Teets, PR Senthilan, PW Hochachka, R David, R Morales-Hojas, R Niwa, RE Lee, RE Lee, RM Robich, RW Salt, S Anders, S Fowler, S Sahar, S Tweedie, V Kellermann, V Kostal, V Koštál, V Koštál, Vr Koštál, W Block, W Huang, WJ Heitler, WL Shen, X Huang, XL Guan, Y Benjamini, ZD Liu   +70 more
core   +2 more sources

A large scale prediction of bacteriocin gene blocks suggests a wide functional spectrum for bacteriocins

, 2015
Bacteriocins are peptide-derived molecules produced by bacteria, whose recently-discovered functions include virulence factors and signalling molecules as well as their better known roles as antibiotics.
Freed, Stefan D, Friedberg, Iddo, Lee, Shaun W, Morton, James T   +3 more
core   +1 more source

Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]

, 2009
OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali, Bacha, Nafees, Lebrihi, Ahmed, Liboz, Thierry, Mathieu, Florence   +4 more
core   +2 more sources

Minimal lactazole scaffold for in vitro thiopeptide bioengineering

Nature Communications, 2020
Lactazole A is a thiopeptide from Streptomyces lactacystinaeus, encoded by a compact 9.8 kb biosynthetic gene cluster. Here, the authors show a platform for in vitro biosynthesis of lactazole A via a combination of a flexible in vitro translation system ...
Alexander A. Vinogradov, Morito Shimomura, Yuki Goto, Taro Ozaki, Shumpei Asamizu, Yoshinori Sugai, Hiroaki Suga, Hiroyasu Onaka   +7 more
doaj   +1 more source

A single Streptomyces symbiont makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosus [PDF]

, 2013
Attine ants are dependent on a cultivated fungus for food and use antibiotics produced by symbiotic Actinobacteria as weedkillers in their fungus gardens. Actinobacterial species belonging to the genera Pseudonocardia, Streptomyces and Amycolatopsis have
Barke, Joerg, Brearley, Charles, Goss, Rebecca J. M., Hill, Lionel, Hutchings, Matthew I., Seipke, Ryan F., Yu, Douglas W.   +6 more
core   +1 more source

Correlation of Guaiacol Production With Presence and Expression of the Guaiacol Biosynthetic Gene Cluster in Alicyclobacillus Spp

eFood
The whole genome sequences of A. dauci DSM 28700, A. fastidiosus KKP 3000 (guaiacol producers), and A. fastidiosus DSM 17978 (non‐guaiacol producer) were firstly determined. Then, the presence of the guaiacol biosynthetic gene cluster in genome sequences
Rui Cai, Yanhui Li, Qi Wang, Hong Guo, Yuxiang Zhang, Yahong Yuan, Qinglin Sheng, Zhouli Wang, Tianli Yue   +8 more
doaj   +1 more source