Results 101 to 110 of about 121,897 (203)

Molecular Biodiversity in Fusarium subglutinans and F. temperatum: A Valuable Tool to Distinguish the Two Sister Species and Determine the Beauvericin Chemotype

Journal of Fungi
Fusarium subglutinans and F. temperatum are widely distributed maize pathogens recognized as distinct species with a species-specific chemotype based on patterns of mycotoxins.
Antonia Susca, Alessandra Villani, Miriam Haidukowski, Filomena Epifani, Antonio F. Logrieco, Antonio Moretti   +5 more
doaj   +1 more source

Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723

BMC Genomics, 2019
Background Phomafungin is a recently reported broad spectrum antifungal compound but its biosynthetic pathway is unknown. We combed publicly available Phoma genomes but failed to find any putative biosynthetic gene cluster that could account for its ...
Swati Sinha, Choy-Eng Nge, Chung Yan Leong, Veronica Ng, Sharon Crasta, Mohammad Alfatah, Falicia Goh, Kia-Ngee Low, Huibin Zhang, Prakash Arumugam, Alexander Lezhava, Swaine L. Chen, Yoganathan Kanagasundaram, Siew Bee Ng, Frank Eisenhaber, Birgit Eisenhaber   +15 more
doaj   +1 more source

A C35 Carotenoid Biosynthetic Pathway [PDF]

, 2003
Upon coexpression with Erwinia geranylgeranyldiphosphate (GGDP) synthase in Escherichia coli, C30 carotenoid synthase CrtM from Staphylococcus aureus produces novel carotenoids with the asymmetrical C35 backbone.
Arnold, Frances H., Umeno, Daisuke
core  

Deregulation of secondary metabolism in a histone deacetylase mutant of Penicillium chrysogenum

MicrobiologyOpen, 2018
The Pc21 g14570 gene of Penicillium chrysogenum encodes an ortholog of a class 2 histone deacetylase termed HdaA which may play a role in epigenetic regulation of secondary metabolism. Deletion of the hdaA gene induces a significant pleiotropic effect on
Fernando Guzman‐Chavez, Oleksandr Salo, Marta Samol, Marco Ries, Jeroen Kuipers, Roel A. L. Bovenberg, Rob J. Vreeken, Arnold J. M. Driessen   +7 more
doaj   +1 more source

Discovery and engineering of an endophytic Pseudomonas strain from Taxus chinensis for efficient production of zeaxanthin diglucoside

Journal of Biological Engineering, 2019
Background Endophytic microorganisms are a rich source of bioactive natural products. They are considered as promising biofertilizers and biocontrol agents due to their growth-promoting interactions with the host plants and their bioactive secondary ...
Ozkan Fidan, Jixun Zhan
doaj   +1 more source

Translating biosynthetic gene clusters into fungal armor and weaponry [PDF]

Nature Chemical Biology, 2015
Filamentous fungi are renowned for the production of a diverse array of secondary metabolites (SMs) where the genetic material required for synthesis of a SM is typically arrayed in a biosynthetic gene cluster (BGC). These natural products are valued for their bioactive properties stemming from their functions in fungal biology, key among those ...
openaire   +2 more sources

Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria

eLife
Microbial competition for trace metals shapes their communities and interactions with humans and plants. Many bacteria scavenge trace metals with metallophores, small molecules that chelate environmental metal ions.
Zachary L Reitz, Bita Pourmohsenin, Melanie Susman, Emil Thomsen, Daniel Roth, Alison Butler, Nadine Ziemert, Marnix H Medema   +7 more
doaj   +1 more source

Identification of Pyrrolizilactone Biosynthetic Gene Cluster with Unique Short‐Chain Dehydrogenase Gene for 3‐Methylproline Formation

ChemistryEurope
Natural products often incorporate nonproteogenic amino acids for diversifying their chemical structures and biological activities. Methylproline is one such building block found in bioactive natural products.
Naoki Kato, Sayaka Hirosawa, Toshihiko Nogawa, Kiyomi Kinugasa, Tohru Taniguchi, Hiroyuki Osada, Shunji Takahashi   +6 more
doaj   +1 more source

Aureolic acids: similar antibiotics with different biosynthetic gene clusters.

Chemistry & biology, 2004
In this issue of Chemistry & Biology, Méndez and colleagues describe the sequence and organization of the chromomycin gene cluster. Unexpectedly, the arrangement is starkly different from the mithramycin biosynthetic cluster, despite similarity in the individual genes and the near identical structures of the two antibiotic aureolic acids.
openaire   +3 more sources

Global Analysis of Natural Products Biosynthetic Diversity Encoded in Fungal Genomes

Journal of Fungi
Fungal secondary metabolites (SMs) represent an invaluable source of therapeutic drugs. Genomics-based approaches to SM discovery have revealed a vast and largely untapped biosynthetic potential within fungal genomes. Here, we used the publicly available
Shu Zhang, Guohui Shi, Xinran Xu, Xu Guo, Sijia Li, Zhiyuan Li, Qi Wu, Wen-Bing Yin   +7 more
doaj   +1 more source