Results 11 to 20 of about 379,309 (342)
Minimum Information about a Biosynthetic Gene cluster. [PDF]
Nature Chemical Biology, 2015 A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters.
M. Medema +153 more
semanticscholar +23 more sources
BiG-FAM: the biosynthetic gene cluster families database [PDF]
Nucleic Acids Research, 2020 Computational analysis of biosynthetic gene clusters (BGCs) has revolutionized natural product discovery by enabling the rapid investigation of secondary metabolic potential within microbial genome sequences.
S. Kautsar +4 more
semanticscholar +4 more sources
Functional Analysis of the Fusarielin Biosynthetic Gene Cluster [PDF]
Molecules, 2016 Fusarielins are polyketides with a decalin core produced by various species of Aspergillus and Fusarium. Although the responsible gene cluster has been identified, the biosynthetic pathway remains to be elucidated.
Aida Droce +7 more
doaj +4 more sources
Biosynthetic Gene Clusters from Swine Gut Microbiome
Microorganisms, 2023 The abuse of antibiotics has become a serious health challenge in the veterinary field. It creates environmental selection pressure on bacteria and facilitates the rapid spread of antibiotic resistance genes. The speed of discovery and application of cost-effective alternatives to antibiotics is slow in pig production.
Leli Wang +7 more
openaire +3 more sources
Mining biosynthetic gene clusters in Virgibacillus genomes [PDF]
BMC Genomics, 2019 Biosynthetic gene clusters produce a wide range of metabolites with activities that are of interest to the pharmaceutical industry. Specific interest is shown towards those metabolites that exhibit antimicrobial activities against multidrug-resistant bacteria that have become a global health threat.
Ghofran Othoum +8 more
openaire +6 more sources
The Biosynthetic Gene Clusters of Aminocoumarin Antibiotics [PDF]
Planta Medica, 2006 Plants and microorganisms are the most important sources of secondary metabolites in nature. For research in the functional genomics of secondary metabolism, and for the biotechnological application of such research by genetic engineering and combinatorial biosynthesis, most microorganisms offer a unique advantage to the researcher: the biosynthetic ...
Shu-Ming, Li, Lutz, Heide
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Valinomycin biosynthetic gene cluster in Streptomyces: conservation, ecology and evolution. [PDF]
PLoS ONE, 2009 Many Streptomyces strains are known to produce valinomycin (VLM) antibiotic and the VLM biosynthetic gene cluster (vlm) has been characterized in two independent isolates.
Andrea M Matter +4 more
doaj +1 more source
Sequence analysis of porothramycin biosynthetic gene cluster [PDF]
Folia Microbiologica, 2014 The biosynthetic gene cluster of porothramycin, a sequence-selective DNA alkylating compound, was identified in the genome of producing strain Streptomyces albus subsp. albus (ATCC 39897) and sequentially characterized. A 39.7 kb long DNA region contains 27 putative genes, 18 of them revealing high similarity with homologous genes from biosynthetic ...
Najmanova, Lucie +8 more
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In silico analyses of maleidride biosynthetic gene clusters [PDF]
Fungal Biology and Biotechnology, 2021 Abstract Maleidrides are a family of structurally related fungal natural products, many of which possess diverse, potent bioactivities. Previous identification of several maleidride biosynthetic gene clusters, and subsequent experimental work, has determined the ‘core’ set of genes required to construct the ...
Katherine Williams +3 more
openaire +6 more sources
Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli. [PDF]
PLoS ONE, 2013 BACKGROUND: Heterologous expression of bacterial biosynthetic gene clusters is currently an indispensable tool for characterizing biosynthetic pathways.
David Cole Stevens +5 more
doaj +1 more source