Results 21 to 30 of about 379,309 (342)

Identification and characterization of a novel diterpene gene cluster in Aspergillus nidulans. [PDF]

PLoS ONE, 2012
Fungal secondary metabolites are a rich source of medically useful compounds due to their pharmaceutical and toxic properties. Sequencing of fungal genomes has revealed numerous secondary metabolite gene clusters, yet products of many of these ...
Kirsi Bromann, Mervi Toivari, Kaarina Viljanen, Anu Vuoristo, Laura Ruohonen, Tiina Nakari-Setälä   +5 more
doaj   +1 more source

Chromatin-level regulation of biosynthetic gene clusters [PDF]

Nature Chemical Biology, 2009
Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans. One new cluster generated monodictyphenone, emodin and emodin derivatives, whereas a second encoded two anti-osteoporosis polyketides, F9775A and F9775B.
Jin Woo, Bok, Yi-Ming, Chiang, Edyta, Szewczyk, Yazmid, Reyes-Dominguez, Ashley D, Davidson, James F, Sanchez, Hsien-Chun, Lo, Kenji, Watanabe, Joseph, Strauss, Berl R, Oakley, Clay C C, Wang, Nancy P, Keller   +11 more
openaire   +2 more sources

Discovery of Pyranoviolin A and Its Biosynthetic Gene Cluster in Aspergillus violaceofuscus

Frontiers in Microbiology, 2020
A new polyketide-non-ribosomal peptide hybrid molecule, pyranoviolin A (1), was discovered from the genome-sequenced fungus Aspergillus violaceofuscus CBS 115571 and was characterized to be the first pyranonigrin analog harboring the C-3 methoxy group ...
Xingxing Wei, Lin Chen, Jian-Wei Tang, Yudai Matsuda, Yudai Matsuda   +4 more
doaj   +1 more source

A Novel Biosynthetic Gene Cluster Across the Pantoea Species Complex Is Important for Pathogenicity in Onion

Molecular Plant-Microbe Interactions, 2023
Onion center rot is caused by at least four species of genus Pantoea (P. ananatis, P. agglomerans, P. allii, and P. stewartii subsp. indologenes). Critical onion pathogenicity determinants for P.
Mei Zhao, Gi Yoon Shin, Shaun Stice, Jonathon Luke Bown, Teresa Coutinho, William W. Metcalf, Ron Gitaitis, Brian Kvitko, Bhabesh Dutta   +8 more
doaj   +1 more source

Deletion of a hybrid NRPS‐T1PKS biosynthetic gene cluster via Latour gene knockout system in Saccharopolyspora pogona and its effect on butenyl‐spinosyn biosynthesis and growth development

Microbial Biotechnology, 2021
Summary Butenyl‐spinosyn, a promising biopesticide produced by Saccharopolyspora pogona, exhibits stronger insecticidal activity and a broader pesticidal spectrum. However, its titre in the wild‐type S.
Jie Rang, Yunlong Li, Li Cao, Ling Shuai, Yang Liu, Haocheng He, Qianqian Wan, Yuewen Luo, Ziquan Yu, Youming Zhang, Yunjun Sun, Xuezhi Ding, Shengbiao Hu, Qingji Xie, Liqiu Xia   +14 more
doaj   +1 more source

Formation and diversification of a paradigm biosynthetic gene cluster in plants

Nature Communications, 2020
Numerous examples of biosynthetic gene clusters (BGCs), including for compounds of agricultural and medicinal importance, have now been discovered in plant genomes.
Zhenhua Liu, Jitender Cheema, Marielle Vigouroux, L. Hill, James Reed, Pirita Paajanen, Levi Yant, A. Osbourn   +7 more
semanticscholar   +1 more source

Genome-Wide Analysis of Biosynthetic Gene Cluster Reveals Correlated Gene Loss with Absence of Usnic Acid in Lichen-Forming Fungi

Genome Biology and Evolution, 2020
Lichen-forming fungi are known to produce a large number of secondary metabolites. Some metabolites are deposited in the cortical layer of the lichen thallus where they exert important ecological functions, such as UV filtering.
David Pizarro, P. Divakar, Felix Grewe, A. Crespo, Francesco Dal Grande, H. Lumbsch   +5 more
semanticscholar   +1 more source

Identification and analysis of the paulomycin biosynthetic gene cluster and titer improvement of the paulomycins in Streptomyces paulus NRRL 8115. [PDF]

PLoS ONE, 2015
The paulomycins are a group of glycosylated compounds featuring a unique paulic acid moiety. To locate their biosynthetic gene clusters, the genomes of two paulomycin producers, Streptomyces paulus NRRL 8115 and Streptomyces sp. YN86, were sequenced. The
Jine Li, Zhoujie Xie, Min Wang, Guomin Ai, Yihua Chen   +4 more
doaj   +1 more source

Heterologous Expression of the Unusual Terreazepine Biosynthetic Gene Cluster Reveals a Promising Approach for Identifying New Chemical Scaffolds

mBio, 2020
Advances in genome sequencing have revitalized natural product discovery efforts, revealing the untapped biosynthetic potential of fungi. While the volume of genomic data continues to expand, discovery efforts are slowed due to the time-consuming nature ...
Lindsay K. Caesar, Matthew T. Robey, Michael Swyers, Md N. Islam, Rosa Ye, Purav P. Vagadia, Gary E. Schiltz, Paul M. Thomas, Chengcang C. Wu, Neil L. Kelleher, Nancy P. Keller, Jin Woo Bok   +11 more
doaj   +1 more source

The Biosynthetic Gene Cluster for Sestermobaraenes—Discovery of a Geranylfarnesyl Diphosphate Synthase and a Multiproduct Sesterterpene Synthase from Streptomyces mobaraensis

Angewandte Chemie, 2020
A biosynthetic gene cluster from Streptomyces mobaraensis encoding the first cases of a bacterial geranylfarnesyl diphosphate synthase and a type I sesterterpene synthase was identified.
Anwei Hou, Jeroen S. Dickschat
semanticscholar   +1 more source