Thiopeptides encoding biosynthetic gene clusters mined from bacterial genomes
Journal of Biosciences, 2021 Currently, we are at the threshold of the 'post-antibiotic era' due to the global emergence of antimicrobial resistance (AMR), and hence there is a dire need to discover new antibiotics. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a diverse class of natural products (NPs), some of which are under clinical trials for ...
Eshani Aggarwal +2 more
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ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNA sequences. [PDF]
PLoS ONE, 2012 Thiopeptides are a growing class of sulfur-rich, highly modified heterocyclic peptides that are mainly active against Gram-positive bacteria including various drug-resistant pathogens.
Jing Li +8 more
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Identification of putative dothistromin biosynthetic genes : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University, Palmerston North, New Zealand [PDF]
, 1998 Dothistromin is a polyketide-derived mycotoxin produced by the Pinus pathogen Dothistroma pini, and is thought to be important in the development of the necrotic disease Dothistroma needle blight.
Monahan, Brendon Joseph
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Transcriptional cellular responses in midgut tissue of Aedes aegypti larvae following intoxication with Cry11Aa toxin from Bacillus thuringiensis. [PDF]
, 2015 BackgroundAlthough much is known about the mechanism of action of Bacillus thuringiensis Cry toxins, the target tissue cellular responses to toxin activity is less understood.
Bravo, Alejandra +4 more
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Electronic Journal of BiotechnologyBackground: Sof Umer Cave is a unique habitat that hosts industrially significant microbes. In this study, Stenotrophomonas sp. ASucR1 was isolated from the cave rock and screened for antimicrobial activity.
Abu Feyisa Meka +4 more
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Identification and engineering of 32 membered antifungal macrolactone notonesomycins
Microbial Cell Factories, 2020 Notonesomycin A is a 32-membered bioactive glycosylated macrolactone known to be produced by Streptomyces aminophilus subsp. notonesogenes 647-AV1 and S. aminophilus DSM 40186.
Falicia Goh +20 more
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Rapid metabolic pathway assembly and modification using serine integrase site-specific recombination [PDF]
, 2013 Synthetic biology requires effective methods to assemble DNA parts into devices and to modify these devices once made. Here we demonstrate a convenient rapid procedure for DNA fragment assembly using site-specific recombination by ϕC31 integrase.
Colloms, S.D. +7 more
core +4 more sources
The Transcriptional Architecture of Bacterial Biosynthetic Gene Clusters
Journal of Natural ProductsAbstractBacteria produce diverse bioactive metabolites with ecological and pharmaceutical importance. These compounds are synthesized by biosynthetic gene clusters (BGCs), whose expression is tightly regulated. While many studies have examined the factors influencing BGC expression, including transcription factors (TFs) and environmental signals, the ...
Ribeiro Monteiro, Silvia +3 more
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Heterologous Expression of Novobiocin and Clorobiocin Biosynthetic Gene Clusters [PDF]
Applied and Environmental Microbiology, 2005 ABSTRACT A method was developed for the heterologous expression of biosynthetic gene clusters in different Streptomyces strains and for the modification of these clusters by single or multiple gene replacements or gene deletions with unprecedented speed and versatility.
Alessandra S, Eustáquio +5 more
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Frontiers in Microbiology, 2019 Two new elaiophylin derivatives, efomycins K (1) and L (2), and five known elaiophylin derivatives (3–7) were isolated from the termite-associated Streptomyces sp. M56. The structures were determined by 1D and 2D NMR and HR-ESIMS analyses and comparative
Jonathan L. Klassen +4 more
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