Novel Bis- and Mono-Pyrrolo[2,3-d]pyrimidine and Purine Derivatives: Synthesis, Computational Analysis and Antiproliferative Evaluation [PDF]
Molecules, 2021 Novel symmetrical bis-pyrrolo[2,3-d]pyrimidines and bis-purines and their monomers were synthesized and evaluated for their antiproliferative activity in human lung adenocarcinoma (A549), cervical carcinoma (HeLa), ductal pancreatic adenocarcinoma (CFPAC-
Andrea Bistrović Popov +6 more
doaj +7 more sources
New Optically Active Bis‐Heterocycles Derived from (S)‐Proline [PDF]
Helvetica Chimica Acta, 2012 AbstractEnantiomerically pure bis‐heterocycles containing a (S)‐proline moiety have been prepared starting from (S)‐N‐benzylprolinehydrazide (2b). The reactions with isothiocyanates or butyl isocyanate in refluxing MeOH led to the corresponding thiosemicarbazide 5 and semicarbazide 9 with a N‐benzylprolinoyl residue.
Pieczonka, Adam M +3 more
openaire +4 more sources
Synthesis and Antimicrobial Studies of New Series of Pyrazoline Bearing Bis-Heterocycles via 1,3-Dipolar Cycloaddition Reactions [PDF]
E-Journal of Chemistry, 2008 Biologically interesting bis-heterocycles bearing pyrazoline and imidazole moieties have been synthesized. 1H NMR, 13C NMR, IR and elemental analyses characterized the newly synthesized compounds.
B. Jayashankara, K. M. Lokanatha Rai
doaj +2 more sources
Combining the most suitable energetic tetrazole and triazole moieties: synthesis and characterization of 5-(1-hydroxy-3-nitro-1,2,4-triazol-5-yl)-1-hydroxy-tetrazole and its nitrogen-rich ionic derivatives [PDF]
, 2022 With the synthesis of 5-(1-hydroxy-3-nitro-1,2,4-triazol-5-yl)-1-hydroxy-tetrazole (1) we can report the first successful production of a combined bis-heterocyclic system composed of 1-hydroxy-tetrazole and 1-hydroxy-1,2,4-triazole.
Bauer, Lukas +4 more
core +1 more source
Autoxidation of 4-Hydrazinylquinolin-2(1H)-one; Synthesis of Pyridazino[4,3-c:5,6-c′ ]diquinoline-6,7(5H,8H)-diones [PDF]
, 2022 An efficient synthesis of a series of pyridazino[4,3-c:5,6-c′]diquinolines was achieved via the autoxidation of 4-hydrazinylquinolin-2(1H)-ones. IR, NMR ($^1$H and $^13$C), mass spectral data, and elemental analysis were used to fit and elucidate the ...
Aly, Ashraf A. +7 more
core +10 more sources
SNAr Isocyanide Diversification [PDF]
, 2022 Isocyanides are important building blocks in organic synthesis; however, their synthesis is time and resource consuming and often unpleasant due to their smelly nature.
Dömling, Alexander +2 more
core +2 more sources
Synthesis of C,N'-linked bis-heterocycles using a deprotometalation-iodination-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells [PDF]
, 2014 International audienceBenzothiophene, benzofuran, benzothiazole and benzoxazole were deprotometalated using the lithium-zinc combination prepared from ZnCl2*TMEDA (TMEDA = N,N,N',N'-tetramethylethylenediamine, 1 equiv) and lithium 2,2,6,6 ...
Bentabed-Ababsa, Ghenia +8 more
core +3 more sources
How Not to Discover a New Reagent. The Evolution and Chemistry of Woollins' Reagent [PDF]
, 2012 The pathways in research can be complex. This review provides a personal account of the winding scientific and funding road that led to Woollins' reagent.
Woollins, J. Derek
core +1 more source
Molecules, 2011 A series of new bis(heterocycles) featuring thieno[2,3-b]thiophene rings was synthesized in a combinatorial manner. Intramolecular cyclization of enaminone derivatives with appropriate N-nucleophiles afforded the target compounds.
Saeed Alshahrani +4 more
doaj +1 more source
Synthesis and Chemical Characterisation of New Bis-Thieno [2,3-b]thiophene Derivatives
Molecules, 2010 Using 3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-dicarbohydrazide as synthon a series of new bis-heterocycles incorporating the thieno[2,3-b]thiophene nucleus was prepared and characterized.
Yahia Nasser Mabkhoot
doaj +1 more source