Results 121 to 130 of about 2,045 (191)

Topoisomerase inhibitors in cervical cancer: mechanistic insights and therapeutic strategies. [PDF]

Mol Med
Reddy Y, Pai P, Das I, Nayak S, D'Souza NV, Shetty MG, Sundara BK.   +6 more
europepmc   +1 more source

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Enantioselective Synthesis of N-N Bisindole Atropisomers.

Angewandte Chemie, 2022
N-N Atropisomers are a common motif in natural products and represent a significant dimension for exploration in modern pharmaceutical and medicinal chemistry.
Peng Zhang, Qi Xu, Xiao‐Mei Wang, Jia Feng, Chuan-Jun Lu, Y. Li, Ren-Rong Liu   +6 more
semanticscholar   +3 more sources

Bisindole alkaloids from Voacanga grandifolia leaves

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, 12'-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very
A. E. Nugroho, Yurika Ono, Eunji Jin, Y. Hirasawa, Toshio Kaneda, Abdul Rahman, I. Kusumawati, T. Tougan, T. Horii, Noor Cholies Zaini, H. Morita   +10 more
semanticscholar   +4 more sources

Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids

Archiv der Pharmazie, 2020
AbstractThe bisindole moiety, as a versatile pharmacophore, is one of the widespread heterocycles in naturally occurring and synthetic bioactive compounds. The bisindole alkaloids derived from natural sources possess structural and mechanistic diversity, and they were found to be generally more active than monoindole alkaloids against various cancer ...
Yue Zhang, Chunhong Hu
openaire   +2 more sources

Bisindole alkaloids from Tabernaemontana corymbosa

Phytochemistry, 2018
Continued study in bioactive monoterpenoid alkaloids led to the isolation of nine undescribed alkaloids, taberyunines A-I, together with 32 known ones from the aerial parts of Tabernaemontana corymbosa Roxb. ex Wall (Apocynaceae). Among the undescribed alkaloids, taberyunines A-G and H-I were assigned to Aspidosperma-Aspidosperma and Vobasinyl-Ibogan ...
Bing-Jie, Zhang, Jing-Song, Lu, Mei-Fen, Bao, Xiu-Hong, Zhong, Ling, Ni, Jing, Wu, Xiang-Hai, Cai   +6 more
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Discovery of Unusual Ajmaline-Macroline Type Bisindole Alkaloids from Alstonia macrophylla by Building Blocks-Based Molecular Networking.

Chemistry, 2023
Three unusual ajmaline-macroline type bisindole alkaloids, alsmaphylines A-C, together with their postulated biogenetic precursors, were isolated from the stem barks and leaves of Alstonia macrophylla via the building blocks-based molecular network (BBMN)
Zi-wei Li, Chun-lin Fan, Biao Sun, Lan Huang, Zi-Qi Wang, Xiao‐Jun Huang, Shi-Qin Zhang, Wen-Cai Ye, Zhen‐Long Wu, Xiao-Qi Zhang   +9 more
semanticscholar   +1 more source

Monoterpenoid Bisindole Alkaloids

2016
This chapter covers the literature on bisindole alkaloids consisting of monoterpenoid indoles, published up to June 2015. Bisindole alkaloids isolated from plants belonging to the families Apocynaceae and Loganiaceae, including Iboga-vobasine type, Aspidosperma-Aspidosperma type, eburnan-Aspidosperma type, Strychnos-Strychnos type, macroline-macroline ...
Mariko, Kitajima, Hiromitsu, Takayama
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Bisindole natural products: A vital source for the development of new anticancer drugs.

European journal of medicinal chemistry, 2022
Currently, the number of new cancer cases and deaths worldwide is increasing year on year. In addition to the requirement for cancer prevention, the top priority is still to seek the effective cure of cancer.
Mengwei Xu, Rui Peng, Qing Min, Siwen Hui, Xin Chen, Guang Yang, Shuanglin Qin   +6 more
semanticscholar   +1 more source

Catalytic repertoire of bacterial bisindole formation

Current Opinion in Chemical Biology, 2016
Bacterial bisindole alkaloids that derive from the oxidative dimerization of l-tryptophan possess diversified biological activities and unique molecular structures. In recent years, the number of bisindoles and their gene clusters has greatly expanded, revealing a large genetic toolbox for the generation of unique structural modifications.
Yi-Ling, Du, Katherine S, Ryan
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Structure of a novel bisindole derivative

Acta Crystallographica Section C Crystal Structure Communications, 1991
(3aR-[3a alpha,4 beta,5a beta,9[1R,3R(2S),5R,7aS,-12aS],10bR,13a alpha])-Methyl-4-(acetyloxy)-3a-ethyl-3a,4,5,5a,6,11,12,13a-oct ahy dro-9- [1,2,3,4,6,7,7a,- 12-octahydro-3-(2-hydroxy-2-hydroxymethylbutyl)- 1-(methoxycarbonyl)indolizino[1,2-b]indol-7a-yl]-5- hydroxy-8-methoxy-6-methyl-1H-indolizino[8,1-c,d]- carbazole-5-carboxylate methanol hydrate ...
V M, Lynch, A, Stamford, P, Magnus, B E, Davis   +3 more
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