Results 161 to 170 of about 1,592 (193)

Synthesis of a novel series of cytotoxic bisindole alkaloids

Bioorganic & Medicinal Chemistry Letters, 2001
Original cytotoxic bisindole alkaloids with a 1,2,3,4-tetrahydroquinoline bridge were synthesized by reductive amination with various anilines. The most cytotoxic compounds display a high and dose-dependent cell cycle effect with accumulation in the G1 phase.
M, Raoul, C, Schaeffer, S, Léonce, A, Pierré, G, Atassi, R, Hocquemiller, G, Lewin   +6 more
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Bisindoles. 30. Acid condensation of bisindoles with aromatic aldehydes and the synthesis of new endole-containing polyamines

Chemistry of Heterocyclic Compounds, 1993
Reaction of 2,2′-diethoxycarbonyl-bis(5-indolyl)sulfone with benzaldehyde gave an active dibromide — 2,2′diethoxycarbonyl-3,3′-di(bromobenzyl)bis(5-indolyl)sulfone; derivatives of di(bisindolyl)phenylmethane have been prepared by condensation of 2,2′-diethoxycarbonyl-bis (N-methyl-5-indolyl)sulfone with benzaldehyde and p-methoxybenzaldhyde.
N. N. Ovsyannikova, Sh. A. Samsoniya, N. N. Suvorov, N. A. Kogan   +3 more
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Alternative partial synthesis of bisindole alkaloids

Tetrahedron Letters, 1990
Abstract Indoline derivatives of the pericyclivine series are oxidized at position 6 with DDQ; the corresponding alcohols are coupled with nucleophilic indolines under acid conditions to yield dimers similar to undulatine.
G. Massiot, J.M. Nuzillard, B. Richard, L. Le Men-Olivier   +3 more
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Development of novel telomerase inhibitors based on a Bisindole unit

Bioorganic & Medicinal Chemistry Letters, 2001
Telomerase is the enzyme that elongates telomere repeat at the ends of a chromosome. As high telomerase activity is observed in most cancer cells, inhibitors of human telomerase have been expected as new chemotherapeutic agents for cancer. We describe here the discovery of novel inhibitors with IC50 values in the submicromolar range.
S, Sasaki, T, Ehara, I, Sakata, Y, Fujino, N, Harada, J, Kimura, H, Nakamura, M, Maeda   +7 more
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Bisindoles

Chemistry of Heterocyclic Compounds, 1979
Sh. A. Samsoniya, M. V. Trapaidze, L. N. Kurkovskaya, L. G. Tret'yakova, T. K. Efimova, N. N. Suvorov   +5 more
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INDIGOID BISINDOLE DERIVATIVES

2000
The present invention relates to novel indigoid binsindole derivatives which can be used for the manufacture of a medicament for the treatment of solid cancers.
openaire   +1 more source

Bisindole

2020
Michio Sato, Shinji Kishimoto, Hiroshi Noguchi, Kenji Watanabe   +3 more
openaire   +1 more source

Synthetic strategies for the construction of C3–N1′ bisindoles

Organic & Biomolecular Chemistry
Natural products having a C3–N1′ bisindole framework are unique structures with potential axial chirality. This minireview summarizes the recent progress of the methodology for constructing C3–N1′ bisindoles along with the possible mechanism.
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The Sources, Structures and Cytotoxicity of Animal‐Derived Bisindole Compounds

Chemistry & Biodiversity
AbstractBisindole compounds constitute a significant class of natural compounds distinguished by their characteristic bisindole structure and renowned for their anticancer properties. Over the past four decades, researchers have isolated 229 animal‐derived bisindole compounds (ADBCs) from various animals.
Zi‐Long Zhang, Hao‐Nan Xu, Chuan‐Ming Gong, Yu‐Ze Li, Yi‐Ming Li, Xiao‐Mei Song, Rui Wang, Dong‐Dong Zhang   +7 more
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Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus

Journal of Natural Medicines
A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a modified iboga type with 1-azatricyclo ring system consisting of one azepane and two piperidine rings coupled with an oxazolidine ring was isolated from Catharanthus roseus, and the structure including absolute stereochemistry was elucidated on the basis of ...
Yusuke, Hirasawa, Ayaka, Kase, Akie, Okamoto, Keigo, Suzuki, Mizuki, Hiroki, Toshio, Kaneda, Nahoko, Uchiyama, Hiroshi, Morita   +7 more
openaire   +2 more sources