Results 1 to 10 of about 1,494 (196)

Marine bisindole alkaloid: A potential apoptotic inducer in human cancer cells [PDF]

European Journal of Histochemistry, 2018
Marine organisms such as corals, sponges and tunicates produce active molecules which could represent a valid starting point for new drug development processes.
Sara Salucci, Sabrina Burattini, Francesca Buontempo, Ester Orsini, Lucia Furiassi, Michele Mari, Simone Lucarini, Alberto M. Martelli, Elisabetta Falcieri   +8 more
doaj   +5 more sources

Efficient and Rapid Arylation of NH₂-Unprotected Bromobisindole Ethanamines via Suzuki-Miyaura Coupling: Generating New Leads Against Leishmania. [PDF]

Chemistry
Leishmaniasis is a neglected tropical disease which presents significant global health challenges due to the lack of effective vaccines and the limitations of existing chemotherapeutics in view of their toxicity, resistance, and high costs. In this study,
Buono A, Diotallevi A, Maestrini S, Verboni M, Kiuru P, Galluzzi L, Duranti A, Olivieri D, Lucarini S.   +8 more
europepmc   +4 more sources

Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms [PDF]

Microorganisms, 2019
The antimicrobial activity of the marine bisindole alkaloid 2,2-bis(6-bromo-3-indolyl) ethylamine (1) and related synthetic analogues (compounds 2⁻8) against target microorganisms was investigated by Minimum Inhibitory Concentration (MIC ...
Raffaella Campana, Gianfranco Favi, Wally Baffone, Simone Lucarini   +3 more
doaj   +3 more sources

A Fluorinated Analogue of Marine Bisindole Alkaloid 2,2-Bis(6-bromo-1H-indol-3-yl)ethanamine as Potential Anti-Biofilm Agent and Antibiotic Adjuvant Against Staphylococcus aureus [PDF]

Pharmaceuticals, 2020
Methicillin resistant Staphylococcus aureus (MRSA) infections represent a major global healthcare problem. Therapeutic options are often limited by the ability of MRSA strains to grow as biofilms on medical devices, where antibiotic persistence and ...
Raffaella Campana, Gianmarco Mangiaterra, Mattia Tiboni, Emanuela Frangipani, Francesca Biavasco, Simone Lucarini, Barbara Citterio   +6 more
doaj   +2 more sources

The Bisindole Alkaloid Caulerpin, from Seaweeds of the Genus Caulerpa, Attenuated Colon Damage in Murine Colitis Model [PDF]

Marine Drugs, 2018
Caulerpin (CLP), an alkaloid from algae of the genus Caulerpa, has shown anti-inflammatory activity. Therefore, this study aimed to analyze the effect of CLP in the murine model of peritonitis and ulcerative colitis.
Alessandra M. M. Lucena, Cássio R. M. Souza, Jéssica T. Jales, Paulo M. M. Guedes, George E. C. de Miranda, Adolpho M. A. de Moura, João X. Araújo-Júnior, George J. Nascimento, Kátia C. Scortecci, Barbara V. O. Santos, Janeusa T. Souto   +10 more
doaj   +2 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

One-Pot Synthesis of Novel β-Carboline-{α-Acylaminoamide}-Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies. [PDF]

ChemistryOpen
A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) employing an atom‐economical one‐pot Ugi four‐component reaction and their antibacterial testing alongside docking studies, is reported. A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi ...
Atri AK, Khullar L, Kumar G, Mishra S, Dua T, Singh V, Harjai K, Singh P, Singh V.   +8 more
europepmc   +2 more sources

Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine. [PDF]

Angew Chem Int Ed Engl
19E‐geissoschizine is a key precursor in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Using enzymatic assays and gene silencing, three CYPs were identified from C. roseus that oxidize this compound to four alkaloid scaffolds: strychnos, sarpagan, akuammiline, and mavacurane. Mutational analysis reveals
Kamileen MO, Hong B, Gase K, Kunert M, Caputi L, Lichman BR, O'Connor SE.   +6 more
europepmc   +3 more sources

The Antinociceptive and Anti-Inflammatory Activities of Caulerpin, a Bisindole Alkaloid Isolated from Seaweeds of the Genus Caulerpa [PDF]

Marine Drugs, 2009
The antinociceptive and anti-inflammatory activity of caulerpin was investigated. This bisindole alkaloid was isolated from the lipoid extract of Caulerpa racemosa and its structure was identified by spectroscopic methods, including IR and NMR techniques.
Magna Suzana Alexandre-Moreira, Bárbara Viviana de Oliveira Santos, Petrônio Filgueiras de Athayde-Filho, José Maria Barbosa-Filho, João Xavier de Araújo-Júnior, Maria Célia de Oliveira Chaves, George Emmanuel C. de Miranda, Vitor Prates Lorenzo, Eliane A. Campessato Mella, Anansa Bezerra de Aquino, Diogo José Costa da Silva, Daysianne Pereira de Lira, Aline Cavalcanti de Queiroz, Éverton Tenório de Souza   +13 more
doaj   +2 more sources

Cytotoxic Activity, and Molecular Docking of Indole Alkaloid Voacangine and Bisindole Alkaloid Vobtusine, Vobtusine Lactone from the Indonesian Plant: Voacanga foetida (Blume) Rolfe [PDF]

Journal of Natural Products, 2021
The purpose of this study was to isolate and test its cytotoxic activity starting from extract fraction and its isolate compound, then carried out molecular docking to confirm the potential biological activity of ligands (vocangine, vobtusine, and ...
Amelia, Puteri, Dachriyanus, Dachriyanus, Frengki, Frengki, Hirasawa, Yusuke, Ikhtiarudin, Ihsan, Kaneda, Toshio, Morita, Hiroshi, Susanty, Adriani, Wahyuni, Fatma Sri, Yanwirasti, Yanwirasti   +9 more
core   +5 more sources